Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy

Markus Sauer; Julius M Weinrich; Christoph Fraune; Georg Salomon; Pierre Tennstedt; Gerhard Adam; Dirk Beyersdorff

doi:10.1016/j.ejrad.2017.11.019

Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy

Standard

Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy. / Sauer, Markus; Weinrich, Julius M; Fraune, Christoph; Salomon, Georg; Tennstedt, Pierre; Adam, Gerhard ; Beyersdorff, Dirk.

In: EUR J RADIOL, Vol. 98, 01.2018, p. 187-192.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sauer, M, Weinrich, JM, Fraune, C, Salomon, G, Tennstedt, P, Adam, G & Beyersdorff, D 2018, 'Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy', EUR J RADIOL, vol. 98, pp. 187-192. https://doi.org/10.1016/j.ejrad.2017.11.019

APA

Sauer, M., Weinrich, J. M., Fraune, C., Salomon, G., Tennstedt, P., Adam, G., & Beyersdorff, D. (2018). Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy. EUR J RADIOL, 98, 187-192. https://doi.org/10.1016/j.ejrad.2017.11.019

Vancouver

Sauer M, Weinrich JM, Fraune C, Salomon G, Tennstedt P, Adam G et al. Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy. EUR J RADIOL. 2018 Jan;98:187-192. https://doi.org/10.1016/j.ejrad.2017.11.019

Bibtex

@article{c2d09a6a12044e929d125a2390f843f7,

title = "Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy",

abstract = "OBJECTIVES: To evaluate the accuracy of assessment of neurovascular bundle (NVB) infiltration using multiparametric magnetic resonance imaging (mpMRI) and PI-RADS V2 prior to prostatectomy.METHODS: The ethics committee approved this retrospective study with waiver of informed consent. N=198 consecutive patients with biopsy proved cancer underwent standardized mpMRI at 3T prior to surgery. NVB infiltration was assessed for each side (a total of 396). Maximum PI-RADS V2 scores were determined for the posterolateral areas adjacent to the NVBs. Imaging results were correlated with postoperative pathology and standard descriptive statistics were calculated.RESULTS: Overall T-staging sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of mpMRI were 64.4%, 89.2%, 82.4%, 76.2% and 78.3%, respectively. In 396 cases NVB infiltration was predicted with 75.3%, 94.0%, 80.2%, 92.1 % and 89.4 % sensitivity, specificity, PPV, NPV and accuracy, respectively. Analyses of 396 NVB and their adjacent PI-RADS V2 scores with pathology revealed significantly more NVB-infiltrations in suspect scores of 5 and 4 vs. uncertain scores of 3-1 (81/264 vs. 16/132, p=0.0001). Considering scores higher than 3 as a criterion of infiltration demonstrated moderate sensitivity and poor specificity (83.5% and 38.8%, respectively). Interobserver agreement of a second reading of a random sample was good (κ=0.64) for NVB infiltrations and moderate (κ=0.59) for PI-RADS V2.CONCLUSIONS: Assessment of infiltration of the neurovascular bundles using mpMRI has valuable diagnostic performance, yet PI-RADS V2 Scores demonstrate limited eligibility. Combined findings offer crucial information for the planning of prostatectomy.",

keywords = "Journal Article",

author = "Markus Sauer and Weinrich, {Julius M} and Christoph Fraune and Georg Salomon and Pierre Tennstedt and Gerhard Adam and Dirk Beyersdorff",

year = "2018",

month = jan,

doi = "10.1016/j.ejrad.2017.11.019",

language = "English",

volume = "98",

pages = "187--192",

journal = "EUR J RADIOL",

issn = "0720-048X",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Accuracy of multiparametric MR imaging with PI-RADS V2 assessment in detecting infiltration of the neurovascular bundles prior to prostatectomy

AU - Sauer, Markus

AU - Weinrich, Julius M

AU - Fraune, Christoph

AU - Salomon, Georg

AU - Tennstedt, Pierre

AU - Adam, Gerhard

AU - Beyersdorff, Dirk

PY - 2018/1

Y1 - 2018/1

N2 - OBJECTIVES: To evaluate the accuracy of assessment of neurovascular bundle (NVB) infiltration using multiparametric magnetic resonance imaging (mpMRI) and PI-RADS V2 prior to prostatectomy.METHODS: The ethics committee approved this retrospective study with waiver of informed consent. N=198 consecutive patients with biopsy proved cancer underwent standardized mpMRI at 3T prior to surgery. NVB infiltration was assessed for each side (a total of 396). Maximum PI-RADS V2 scores were determined for the posterolateral areas adjacent to the NVBs. Imaging results were correlated with postoperative pathology and standard descriptive statistics were calculated.RESULTS: Overall T-staging sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of mpMRI were 64.4%, 89.2%, 82.4%, 76.2% and 78.3%, respectively. In 396 cases NVB infiltration was predicted with 75.3%, 94.0%, 80.2%, 92.1 % and 89.4 % sensitivity, specificity, PPV, NPV and accuracy, respectively. Analyses of 396 NVB and their adjacent PI-RADS V2 scores with pathology revealed significantly more NVB-infiltrations in suspect scores of 5 and 4 vs. uncertain scores of 3-1 (81/264 vs. 16/132, p=0.0001). Considering scores higher than 3 as a criterion of infiltration demonstrated moderate sensitivity and poor specificity (83.5% and 38.8%, respectively). Interobserver agreement of a second reading of a random sample was good (κ=0.64) for NVB infiltrations and moderate (κ=0.59) for PI-RADS V2.CONCLUSIONS: Assessment of infiltration of the neurovascular bundles using mpMRI has valuable diagnostic performance, yet PI-RADS V2 Scores demonstrate limited eligibility. Combined findings offer crucial information for the planning of prostatectomy.

AB - OBJECTIVES: To evaluate the accuracy of assessment of neurovascular bundle (NVB) infiltration using multiparametric magnetic resonance imaging (mpMRI) and PI-RADS V2 prior to prostatectomy.METHODS: The ethics committee approved this retrospective study with waiver of informed consent. N=198 consecutive patients with biopsy proved cancer underwent standardized mpMRI at 3T prior to surgery. NVB infiltration was assessed for each side (a total of 396). Maximum PI-RADS V2 scores were determined for the posterolateral areas adjacent to the NVBs. Imaging results were correlated with postoperative pathology and standard descriptive statistics were calculated.RESULTS: Overall T-staging sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of mpMRI were 64.4%, 89.2%, 82.4%, 76.2% and 78.3%, respectively. In 396 cases NVB infiltration was predicted with 75.3%, 94.0%, 80.2%, 92.1 % and 89.4 % sensitivity, specificity, PPV, NPV and accuracy, respectively. Analyses of 396 NVB and their adjacent PI-RADS V2 scores with pathology revealed significantly more NVB-infiltrations in suspect scores of 5 and 4 vs. uncertain scores of 3-1 (81/264 vs. 16/132, p=0.0001). Considering scores higher than 3 as a criterion of infiltration demonstrated moderate sensitivity and poor specificity (83.5% and 38.8%, respectively). Interobserver agreement of a second reading of a random sample was good (κ=0.64) for NVB infiltrations and moderate (κ=0.59) for PI-RADS V2.CONCLUSIONS: Assessment of infiltration of the neurovascular bundles using mpMRI has valuable diagnostic performance, yet PI-RADS V2 Scores demonstrate limited eligibility. Combined findings offer crucial information for the planning of prostatectomy.

KW - Journal Article

U2 - 10.1016/j.ejrad.2017.11.019

DO - 10.1016/j.ejrad.2017.11.019

M3 - SCORING: Journal article

C2 - 29279161

VL - 98

SP - 187

EP - 192

JO - EUR J RADIOL

JF - EUR J RADIOL

SN - 0720-048X

ER -