Accuracy of life tables in predicting overall survival in candidates for radiotherapy for prostate cancer.

  • Jochen Walz
  • Andrea Gallina
  • Georg Hutterer
  • Paul Perrotte
  • Shahrokh F Shariat
  • Markus Graefen
  • Michael McCormack
  • Francois Bénard
  • Luc Valiquette
  • Fred Saad
  • Pierre I Karakiewicz

Related Research units

Abstract

PURPOSE: To test the accuracy of life tables (LTs) in predicting survival in men treated with radiotherapy for localized prostate cancer. METHODS AND MATERIALS: We selected the records of 3,176 patients treated with radiotherapy and who had no clinical evidence of disease relapse. Life table-derived life expectancy (LE) was defined for every individual using a population-specific LT. Age, Charlson Comorbidity Index (CCI), and LT-derived LE were then used as predictors of overall mortality in Cox regression models. Predictive accuracy (PA) was estimated with the Harrell's concordance index and was internally validated with 200 bootstrap resamples. RESULTS: The actuarial median survival was 4.7 years (mean, 6.4 years). At radiotherapy, median age was 70.6 years, median CCI was 2, and median LT-derived LE was 12 years. All variables were statistically significant predictors of overall mortality (all p values

Bibliographical data

Original languageGerman
Article number1
ISSN0360-3016
Publication statusPublished - 2007
pubmed 17446004