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Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.

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Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity. / Spyridopoulos, Ioakim; Hoffmann, Jedrzej; Aicher, Alexandra; Brümmendorf, Tim; Doerr, Hans W; Zeiher, Andreas M; Dimmeler, Stefanie.

In: CIRCULATION, Vol. 120, No. 14, 14, 2009, p. 1364-1372.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Spyridopoulos, I, Hoffmann, J, Aicher, A, Brümmendorf, T, Doerr, HW, Zeiher, AM & Dimmeler, S 2009, 'Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.', CIRCULATION, vol. 120, no. 14, 14, pp. 1364-1372. <http://www.ncbi.nlm.nih.gov/pubmed/19770396?dopt=Citation>

APA

Spyridopoulos, I., Hoffmann, J., Aicher, A., Brümmendorf, T., Doerr, H. W., Zeiher, A. M., & Dimmeler, S. (2009). Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity. CIRCULATION, 120(14), 1364-1372. [14]. http://www.ncbi.nlm.nih.gov/pubmed/19770396?dopt=Citation

Vancouver

Spyridopoulos I, Hoffmann J, Aicher A, Brümmendorf T, Doerr HW, Zeiher AM et al. Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity. CIRCULATION. 2009;120(14):1364-1372. 14.

Bibtex

@article{77d057682ebb46688c3ae174de2aae11,
title = "Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.",
abstract = "BACKGROUND: Shortening of mean telomere length (TL) in white blood cells is correlated with the development of coronary heart disease (CHD) and with increased mortality due to infectious disease. The goal of the present study was to investigate whether telomere shortening in CHD is restricted to specific peripheral blood lymphocyte and/or myeloid cell subpopulations. Results were correlated to TL in CD34+ hematopoietic peripheral blood stem cells and progenitor cells obtained from the same individual patients. METHODS AND RESULTS: TL was measured by multicolor flow cytometry-fluorescent in situ hybridization in 12 leukocyte subpopulations after immunomagnetic bead sorting. We investigated TL in 14 young (mean age 25 years) and 13 older (mean age 65 years) healthy male volunteers and in 25 age-matched patients with CHD (mean age 65 years). We show that TL in granulocytes and monocytes mirrors TL of CD34+ peripheral blood stem cells and progenitor cells extremely well (r=0.95, P",
author = "Ioakim Spyridopoulos and Jedrzej Hoffmann and Alexandra Aicher and Tim Br{\"u}mmendorf and Doerr, {Hans W} and Zeiher, {Andreas M} and Stefanie Dimmeler",
year = "2009",
language = "Deutsch",
volume = "120",
pages = "1364--1372",
journal = "CIRCULATION",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "14",

}

RIS

TY - JOUR

T1 - Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.

AU - Spyridopoulos, Ioakim

AU - Hoffmann, Jedrzej

AU - Aicher, Alexandra

AU - Brümmendorf, Tim

AU - Doerr, Hans W

AU - Zeiher, Andreas M

AU - Dimmeler, Stefanie

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Shortening of mean telomere length (TL) in white blood cells is correlated with the development of coronary heart disease (CHD) and with increased mortality due to infectious disease. The goal of the present study was to investigate whether telomere shortening in CHD is restricted to specific peripheral blood lymphocyte and/or myeloid cell subpopulations. Results were correlated to TL in CD34+ hematopoietic peripheral blood stem cells and progenitor cells obtained from the same individual patients. METHODS AND RESULTS: TL was measured by multicolor flow cytometry-fluorescent in situ hybridization in 12 leukocyte subpopulations after immunomagnetic bead sorting. We investigated TL in 14 young (mean age 25 years) and 13 older (mean age 65 years) healthy male volunteers and in 25 age-matched patients with CHD (mean age 65 years). We show that TL in granulocytes and monocytes mirrors TL of CD34+ peripheral blood stem cells and progenitor cells extremely well (r=0.95, P

AB - BACKGROUND: Shortening of mean telomere length (TL) in white blood cells is correlated with the development of coronary heart disease (CHD) and with increased mortality due to infectious disease. The goal of the present study was to investigate whether telomere shortening in CHD is restricted to specific peripheral blood lymphocyte and/or myeloid cell subpopulations. Results were correlated to TL in CD34+ hematopoietic peripheral blood stem cells and progenitor cells obtained from the same individual patients. METHODS AND RESULTS: TL was measured by multicolor flow cytometry-fluorescent in situ hybridization in 12 leukocyte subpopulations after immunomagnetic bead sorting. We investigated TL in 14 young (mean age 25 years) and 13 older (mean age 65 years) healthy male volunteers and in 25 age-matched patients with CHD (mean age 65 years). We show that TL in granulocytes and monocytes mirrors TL of CD34+ peripheral blood stem cells and progenitor cells extremely well (r=0.95, P

M3 - SCORING: Zeitschriftenaufsatz

VL - 120

SP - 1364

EP - 1372

JO - CIRCULATION

JF - CIRCULATION

SN - 0009-7322

IS - 14

M1 - 14

ER -