Absorption, excretion and retention of 51Cr from labelled Cr-(III)-picolinate in rats.
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Absorption, excretion and retention of 51Cr from labelled Cr-(III)-picolinate in rats. / Kottwitz, Karin; Laschinsky, Niels; Fischer, Roland; Nielsen, Peter.
In: BIOMETALS, Vol. 22, No. 2, 2, 2009, p. 289-295.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Absorption, excretion and retention of 51Cr from labelled Cr-(III)-picolinate in rats.
AU - Kottwitz, Karin
AU - Laschinsky, Niels
AU - Fischer, Roland
AU - Nielsen, Peter
PY - 2009
Y1 - 2009
N2 - The bioavailability of chromium from Cr-picolinate (CrPic(3)) and Cr-chloride (CrCl(3)) was studied in rats using (51)Cr-labelled compounds and whole-body-counting. The intestinal absorption of Cr was twice as high from CrPic(3) (1.16% vs 0.55%) than from CrCl(3), however most of the absorbed (51)Cr from CrPic(3) was excreted into the urine within 24 h. After i.v. or i.p. injection, the whole-body retention curves fitted well to a multiexponential function, demonstrating that plasma chromium is in equilibrium with three pools. For CrPic(3), a large pool exists with a very rapid exchange (T (1/2) =
AB - The bioavailability of chromium from Cr-picolinate (CrPic(3)) and Cr-chloride (CrCl(3)) was studied in rats using (51)Cr-labelled compounds and whole-body-counting. The intestinal absorption of Cr was twice as high from CrPic(3) (1.16% vs 0.55%) than from CrCl(3), however most of the absorbed (51)Cr from CrPic(3) was excreted into the urine within 24 h. After i.v. or i.p. injection, the whole-body retention curves fitted well to a multiexponential function, demonstrating that plasma chromium is in equilibrium with three pools. For CrPic(3), a large pool exists with a very rapid exchange (T (1/2) =
M3 - SCORING: Zeitschriftenaufsatz
VL - 22
SP - 289
EP - 295
JO - BIOMETALS
JF - BIOMETALS
SN - 0966-0844
IS - 2
M1 - 2
ER -