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Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging

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Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. / Kallenberg, Kai; Goldmann, Torben; Menke, Jan; Strik, Herwig; Bock, Hans C; Mohr, Alexander; Buhk, Jan H; Frahm, Jens; Dechent, Peter; Knauth, Michael.

In: FOLIA NEUROPATHOL, Vol. 52, No. 3, 01.01.2014, p. 226-33.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kallenberg, K, Goldmann, T, Menke, J, Strik, H, Bock, HC, Mohr, A, Buhk, JH, Frahm, J, Dechent, P & Knauth, M 2014, 'Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging', FOLIA NEUROPATHOL, vol. 52, no. 3, pp. 226-33.

APA

Kallenberg, K., Goldmann, T., Menke, J., Strik, H., Bock, H. C., Mohr, A., Buhk, J. H., Frahm, J., Dechent, P., & Knauth, M. (2014). Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. FOLIA NEUROPATHOL, 52(3), 226-33.

Vancouver

Kallenberg K, Goldmann T, Menke J, Strik H, Bock HC, Mohr A et al. Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging. FOLIA NEUROPATHOL. 2014 Jan 1;52(3):226-33.

Bibtex

@article{d5d2c0116a7f4ddbb1ace145ac6a2ed7,
title = "Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging",
abstract = "INTRODUCTION: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized.MATERIAL AND METHODS: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls.RESULTS: Apparent diffusion coefficient levels of the entire contralateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location.CONCLUSIONS: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor.",
author = "Kai Kallenberg and Torben Goldmann and Jan Menke and Herwig Strik and Bock, {Hans C} and Alexander Mohr and Buhk, {Jan H} and Jens Frahm and Peter Dechent and Michael Knauth",
year = "2014",
month = jan,
day = "1",
language = "English",
volume = "52",
pages = "226--33",
journal = "FOLIA NEUROPATHOL",
issn = "1641-4640",
publisher = "Termedia Publishing House Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging

AU - Kallenberg, Kai

AU - Goldmann, Torben

AU - Menke, Jan

AU - Strik, Herwig

AU - Bock, Hans C

AU - Mohr, Alexander

AU - Buhk, Jan H

AU - Frahm, Jens

AU - Dechent, Peter

AU - Knauth, Michael

PY - 2014/1/1

Y1 - 2014/1/1

N2 - INTRODUCTION: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized.MATERIAL AND METHODS: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls.RESULTS: Apparent diffusion coefficient levels of the entire contralateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location.CONCLUSIONS: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor.

AB - INTRODUCTION: Malignant brain tumors tend to migration and invasion of surrounding brain tissue. Histopathological studies reported malignant cells in macroscopically unsuspicious parenchyma (normal appearing white matter - NAWM) remote from the tumor localization. In early stages, diffuse interneural infiltration with changes of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) is hypothesized.MATERIAL AND METHODS: Patients' ADC and FA values from NAWM of the hemisphere contralateral to a malignant glioma were compared to age- and sex-matched normal controls.RESULTS: Apparent diffusion coefficient levels of the entire contralateral hemisphere revealed a significant increase and a decrease of FA levels. An even more pronounced ADC increase was found in a region mirroring the glioma location.CONCLUSIONS: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor.

M3 - SCORING: Journal article

C2 - 25310733

VL - 52

SP - 226

EP - 233

JO - FOLIA NEUROPATHOL

JF - FOLIA NEUROPATHOL

SN - 1641-4640

IS - 3

ER -