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Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status

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Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status. / Li, Shumei; Daamen, Marcel; Scheef, Lukas; Gaertner, Florian C; Buchert, Ralph; Buchmann, Martina; Buerger, Katharina; Catak, Cihan; Dobisch, Laura; Drzezga, Alexander; Ertl-Wagner, Birgit; Essler, Markus; Fliessbach, Klaus; Haynes, John Dylan; Incesoy, Enise Irem; Kilimann, Ingo; Krause, Bernd J; Lange, Catharina; Laske, Christoph; Priller, Josef; Ramirez, Alfredo; Reimold, Matthias; Rominger, Axel; Roy, Nina; Scheffler, Klaus; Maurer, Angelika; Schneider, Anja; Spottke, Annika; Spruth, Eike Jakob; Teipel, Stefan J; Tscheuschler, Maike; Wolfsgruber, Steffen; Düzel, Emrah; Jessen, Frank; Peters, Oliver; Boecker, Henning; DELCODE Study Group.

In: J ALZHEIMERS DIS, Vol. 79, No. 2, 19.01.2021, p. 493-509.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Li, S, Daamen, M, Scheef, L, Gaertner, FC, Buchert, R, Buchmann, M, Buerger, K, Catak, C, Dobisch, L, Drzezga, A, Ertl-Wagner, B, Essler, M, Fliessbach, K, Haynes, JD, Incesoy, EI, Kilimann, I, Krause, BJ, Lange, C, Laske, C, Priller, J, Ramirez, A, Reimold, M, Rominger, A, Roy, N, Scheffler, K, Maurer, A, Schneider, A, Spottke, A, Spruth, EJ, Teipel, SJ, Tscheuschler, M, Wolfsgruber, S, Düzel, E, Jessen, F, Peters, O, Boecker, H & DELCODE Study Group 2021, 'Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status', J ALZHEIMERS DIS, vol. 79, no. 2, pp. 493-509. https://doi.org/10.3233/JAD-200472

APA

Li, S., Daamen, M., Scheef, L., Gaertner, F. C., Buchert, R., Buchmann, M., Buerger, K., Catak, C., Dobisch, L., Drzezga, A., Ertl-Wagner, B., Essler, M., Fliessbach, K., Haynes, J. D., Incesoy, E. I., Kilimann, I., Krause, B. J., Lange, C., Laske, C., ... DELCODE Study Group (2021). Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status. J ALZHEIMERS DIS, 79(2), 493-509. https://doi.org/10.3233/JAD-200472

Vancouver

Li S, Daamen M, Scheef L, Gaertner FC, Buchert R, Buchmann M et al. Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status. J ALZHEIMERS DIS. 2021 Jan 19;79(2):493-509. https://doi.org/10.3233/JAD-200472

Bibtex

@article{eebecf623af748dabdbe28876c6aea9c,
title = "Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status",
abstract = "BACKGROUND: Amyloid-β accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework.OBJECTIVE: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus.METHODS: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDAβ+) and amyloidnegative SCD (SCDβ-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVR=⫖FBB).RESULTS: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDAβ+patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDAβ+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDAβ+) and precuneus SUVRFBB (both groups).CONCLUSION: While partial confounding influences due to a higher APOE ε4 carrier ratio among SCDAβ+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-β load, highlighting incipient pathology in stage 2 of the AD continuum.",
author = "Shumei Li and Marcel Daamen and Lukas Scheef and Gaertner, {Florian C} and Ralph Buchert and Martina Buchmann and Katharina Buerger and Cihan Catak and Laura Dobisch and Alexander Drzezga and Birgit Ertl-Wagner and Markus Essler and Klaus Fliessbach and Haynes, {John Dylan} and Incesoy, {Enise Irem} and Ingo Kilimann and Krause, {Bernd J} and Catharina Lange and Christoph Laske and Josef Priller and Alfredo Ramirez and Matthias Reimold and Axel Rominger and Nina Roy and Klaus Scheffler and Angelika Maurer and Anja Schneider and Annika Spottke and Spruth, {Eike Jakob} and Teipel, {Stefan J} and Maike Tscheuschler and Steffen Wolfsgruber and Emrah D{\"u}zel and Frank Jessen and Oliver Peters and Henning Boecker and {DELCODE Study Group}",
year = "2021",
month = jan,
day = "19",
doi = "10.3233/JAD-200472",
language = "English",
volume = "79",
pages = "493--509",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

RIS

TY - JOUR

T1 - Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status

AU - Li, Shumei

AU - Daamen, Marcel

AU - Scheef, Lukas

AU - Gaertner, Florian C

AU - Buchert, Ralph

AU - Buchmann, Martina

AU - Buerger, Katharina

AU - Catak, Cihan

AU - Dobisch, Laura

AU - Drzezga, Alexander

AU - Ertl-Wagner, Birgit

AU - Essler, Markus

AU - Fliessbach, Klaus

AU - Haynes, John Dylan

AU - Incesoy, Enise Irem

AU - Kilimann, Ingo

AU - Krause, Bernd J

AU - Lange, Catharina

AU - Laske, Christoph

AU - Priller, Josef

AU - Ramirez, Alfredo

AU - Reimold, Matthias

AU - Rominger, Axel

AU - Roy, Nina

AU - Scheffler, Klaus

AU - Maurer, Angelika

AU - Schneider, Anja

AU - Spottke, Annika

AU - Spruth, Eike Jakob

AU - Teipel, Stefan J

AU - Tscheuschler, Maike

AU - Wolfsgruber, Steffen

AU - Düzel, Emrah

AU - Jessen, Frank

AU - Peters, Oliver

AU - Boecker, Henning

AU - DELCODE Study Group

PY - 2021/1/19

Y1 - 2021/1/19

N2 - BACKGROUND: Amyloid-β accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework.OBJECTIVE: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus.METHODS: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDAβ+) and amyloidnegative SCD (SCDβ-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVR=⫖FBB).RESULTS: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDAβ+patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDAβ+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDAβ+) and precuneus SUVRFBB (both groups).CONCLUSION: While partial confounding influences due to a higher APOE ε4 carrier ratio among SCDAβ+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-β load, highlighting incipient pathology in stage 2 of the AD continuum.

AB - BACKGROUND: Amyloid-β accumulation was found to alter precuneus-based functional connectivity (FC) in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia, but its impact is less clear in subjective cognitive decline (SCD), which in combination with AD pathologic change is theorized to correspond to stage 2 of the Alzheimer's continuum in the 2018 NIA-AA research framework.OBJECTIVE: This study addresses how amyloid pathology relates to resting-state fMRI FC in SCD, especially focusing on the precuneus.METHODS: From the DELCODE cohort, two groups of 24 age- and gender-matched amyloid-positive (SCDAβ+) and amyloidnegative SCD (SCDβ-) patients were selected according to visual [18F]-Florbetaben (FBB) PET readings, and studied with resting-state fMRI. Local (regional homogeneity [ReHo], fractional amplitude of low-frequency fluctuations [fALFF]) and global (degree centrality [DC], precuneus seed-based FC) measures were compared between groups. Follow-up correlation analyses probed relationships of group differences with global and precuneal amyloid load, as measured by FBB standard uptake value ratios (SUVR=⫖FBB).RESULTS: ReHo was significantly higher (voxel-wise p < 0.01, cluster-level p < 0.05) in the bilateral precuneus for SCDAβ+patients, whereas fALFF was not altered between groups. Relatively higher precuneus-based FC with occipital areas (but no altered DC) was observed in SCDAβ+ patients. In this latter cluster, precuneus-occipital FC correlated positively with global (SCDAβ+) and precuneus SUVRFBB (both groups).CONCLUSION: While partial confounding influences due to a higher APOE ε4 carrier ratio among SCDAβ+ patients cannot be excluded, exploratory results indicate functional alterations in the precuneus hub region that were related to amyloid-β load, highlighting incipient pathology in stage 2 of the AD continuum.

U2 - 10.3233/JAD-200472

DO - 10.3233/JAD-200472

M3 - SCORING: Journal article

C2 - 33337359

VL - 79

SP - 493

EP - 509

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 2

ER -