Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease.
Standard
Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease. / Orth, Michael; Schippling, Sven; Schneider, Susanne A; Bhatia, Kailash P; Talelli, Penelope; Tabrizi, Sarah J; Rothwell, John C.
In: J NEUROL NEUROSUR PS, Vol. 81, No. 3, 3, 2010, p. 267-270.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease.
AU - Orth, Michael
AU - Schippling, Sven
AU - Schneider, Susanne A
AU - Bhatia, Kailash P
AU - Talelli, Penelope
AU - Tabrizi, Sarah J
AU - Rothwell, John C
PY - 2010
Y1 - 2010
N2 - Cognition is affected early in Huntington disease (HD), and in HD animal models there is evidence that this reflects abnormal synaptic plasticity. The authors investigated whether there is any evidence for abnormal synaptic plasticity using the human motor cortex-rTMS model and, if so, if there is any difference between premanifest HD gene carriers and very early manifest HD patients or any relationship with ratings of the severity of motor signs.
AB - Cognition is affected early in Huntington disease (HD), and in HD animal models there is evidence that this reflects abnormal synaptic plasticity. The authors investigated whether there is any evidence for abnormal synaptic plasticity using the human motor cortex-rTMS model and, if so, if there is any difference between premanifest HD gene carriers and very early manifest HD patients or any relationship with ratings of the severity of motor signs.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Cognition Disorders diagnosis
KW - Statistics as Topic
KW - Early Diagnosis
KW - Electric Stimulation
KW - Neuronal Plasticity genetics
KW - Theta Rhythm
KW - Evoked Potentials, Motor physiology
KW - Heterozygote Detection
KW - Huntington Disease diagnosis
KW - Mental Status Schedule
KW - Motor Cortex physiopathology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Cognition Disorders diagnosis
KW - Statistics as Topic
KW - Early Diagnosis
KW - Electric Stimulation
KW - Neuronal Plasticity genetics
KW - Theta Rhythm
KW - Evoked Potentials, Motor physiology
KW - Heterozygote Detection
KW - Huntington Disease diagnosis
KW - Mental Status Schedule
KW - Motor Cortex physiopathology
M3 - SCORING: Zeitschriftenaufsatz
VL - 81
SP - 267
EP - 270
JO - J NEUROL NEUROSUR PS
JF - J NEUROL NEUROSUR PS
SN - 0022-3050
IS - 3
M1 - 3
ER -