A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression
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A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression. / Rades, D; Veninga, T; Bajrovic, A; Karstens, J H; Schild, S E.
In: STRAHLENTHER ONKOL, Vol. 189, No. 6, 01.06.2013, p. 462-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - A validated scoring system to identify long-term survivors after radiotherapy for metastatic spinal cord compression
AU - Rades, D
AU - Veninga, T
AU - Bajrovic, A
AU - Karstens, J H
AU - Schild, S E
PY - 2013/6/1
Y1 - 2013/6/1
N2 - PURPOSE: This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC).PATIENTS AND METHODS: Data from 1,125 patients who had received long-course RT for MSCC were included in this study. Of these patients, 344 survived for over 12 months and 781 died within a year following RT. Based on differences between the distributions of patient characteristics in the two groups, a scoring system was developed. Scores ranged from 0 to 18 points and 15 points was selected as the cutoff for identifying long-term survivors. Data from the 1,125 long-course RT patients (test group) were compared to data from 773 patients receiving short-course RT (validation group).RESULTS: A score of ≥ 15 points was associated with a 94 % proportion of long-term survivors. The 15-point cutoff resulted in a specificity of 98 % and a positive predictive value of 94 % for identification of long-term surviving patients. The proportions of long-term survivors for each scoring point in the validation group were very similar to those in the test group.CONCLUSION: This new scoring system enabled identification of long-term survivors after RT for MSCC with very high specificity and positive predictive value. The score proved to be valid and reproducible.
AB - PURPOSE: This study aimed to develop and validate a scoring system to identify long-term survivors after conventional radiotherapy (RT) for metastatic spinal cord compression (MSCC).PATIENTS AND METHODS: Data from 1,125 patients who had received long-course RT for MSCC were included in this study. Of these patients, 344 survived for over 12 months and 781 died within a year following RT. Based on differences between the distributions of patient characteristics in the two groups, a scoring system was developed. Scores ranged from 0 to 18 points and 15 points was selected as the cutoff for identifying long-term survivors. Data from the 1,125 long-course RT patients (test group) were compared to data from 773 patients receiving short-course RT (validation group).RESULTS: A score of ≥ 15 points was associated with a 94 % proportion of long-term survivors. The 15-point cutoff resulted in a specificity of 98 % and a positive predictive value of 94 % for identification of long-term surviving patients. The proportions of long-term survivors for each scoring point in the validation group were very similar to those in the test group.CONCLUSION: This new scoring system enabled identification of long-term survivors after RT for MSCC with very high specificity and positive predictive value. The score proved to be valid and reproducible.
KW - Aged
KW - Disease Progression
KW - Female
KW - Germany
KW - Humans
KW - Long-Term Care
KW - Male
KW - Middle Aged
KW - Neurologic Examination
KW - Particle Accelerators
KW - Radiotherapy Planning, Computer-Assisted
KW - Spinal Cord Compression
KW - Spinal Neoplasms
KW - Survivors
U2 - 10.1007/s00066-013-0342-1
DO - 10.1007/s00066-013-0342-1
M3 - SCORING: Journal article
C2 - 23604188
VL - 189
SP - 462
EP - 466
JO - STRAHLENTHER ONKOL
JF - STRAHLENTHER ONKOL
SN - 0179-7158
IS - 6
ER -
