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A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression

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A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression. / Rades, Dirk; Evers, Jasmin N; Rudat, Volker; Bajrovic, Amira; Karstens, Johann H; Schild, Steven E.

In: BMC CANCER, Vol. 14, 2014, p. 589.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Evers, JN, Rudat, V, Bajrovic, A, Karstens, JH & Schild, SE 2014, 'A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression', BMC CANCER, vol. 14, pp. 589. https://doi.org/10.1186/1471-2407-14-589

APA

Rades, D., Evers, J. N., Rudat, V., Bajrovic, A., Karstens, J. H., & Schild, S. E. (2014). A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression. BMC CANCER, 14, 589. https://doi.org/10.1186/1471-2407-14-589

Vancouver

Rades D, Evers JN, Rudat V, Bajrovic A, Karstens JH, Schild SE. A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression. BMC CANCER. 2014;14:589. https://doi.org/10.1186/1471-2407-14-589

Bibtex

@article{bfc0700f2e2b4c419bd5dd171856c2bb,
title = "A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression",
abstract = "BACKGROUND: This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients.METHODS: 1,129 elderly patients (≥65 years) were assigned to the test (N = 565) or validation group (N = 564). In the test group, nine pre-treatment factors (age, gender, tumor type, number of involved vertebrae, pre-RT ambulatory status, other bone metastases, visceral metastases, interval cancer diagnosis to RT, time developing motor deficits) and fractionation regimen were investigated. Factors significantly associated with post-RT ambulatory status on multivariate analysis were included in the score. The score for each factor was determined by dividing the post-RT ambulatory rate at 1 month (%) by 10. The total score represented the sum of these scores.RESULTS: In the multivariate analysis of the test group, age, primary tumor type, pre-RT ambulatory status, visceral metastases, and time developing motor deficits were significantly associated with post-RT ambulatory status. Total scores were 19 to 41 points. In the test group, post-RT ambulatory rates were 5% for 19-25 points, 35% for 26-30 points, 80% for 31-34 points, and 98% for 35-41 points (p < 0.001). 6-month survival rates were 11%, 21%, 59% and 76%, respectively. In the validation group, post-RT ambulatory rates were 4%, 33%, 77% and 98%, respectively (p < 0.001).CONCLUSIONS: Patients achieving 19-25 points had very poor functional outcomes and survival, and may receive single-fraction RT for pain relief. Selected patients with 26-34 points may benefit from additional surgery. Patients achieving ≥35 points achieved favorable results after RT alone.",
keywords = "Aged, Aged, 80 and over, Female, Humans, Male, Multivariate Analysis, Prognosis, Risk Assessment, Spinal Cord Compression, Spinal Neoplasms, Survival Analysis, Walking",
author = "Dirk Rades and Evers, {Jasmin N} and Volker Rudat and Amira Bajrovic and Karstens, {Johann H} and Schild, {Steven E}",
year = "2014",
doi = "10.1186/1471-2407-14-589",
language = "English",
volume = "14",
pages = "589",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression

AU - Rades, Dirk

AU - Evers, Jasmin N

AU - Rudat, Volker

AU - Bajrovic, Amira

AU - Karstens, Johann H

AU - Schild, Steven E

PY - 2014

Y1 - 2014

N2 - BACKGROUND: This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients.METHODS: 1,129 elderly patients (≥65 years) were assigned to the test (N = 565) or validation group (N = 564). In the test group, nine pre-treatment factors (age, gender, tumor type, number of involved vertebrae, pre-RT ambulatory status, other bone metastases, visceral metastases, interval cancer diagnosis to RT, time developing motor deficits) and fractionation regimen were investigated. Factors significantly associated with post-RT ambulatory status on multivariate analysis were included in the score. The score for each factor was determined by dividing the post-RT ambulatory rate at 1 month (%) by 10. The total score represented the sum of these scores.RESULTS: In the multivariate analysis of the test group, age, primary tumor type, pre-RT ambulatory status, visceral metastases, and time developing motor deficits were significantly associated with post-RT ambulatory status. Total scores were 19 to 41 points. In the test group, post-RT ambulatory rates were 5% for 19-25 points, 35% for 26-30 points, 80% for 31-34 points, and 98% for 35-41 points (p < 0.001). 6-month survival rates were 11%, 21%, 59% and 76%, respectively. In the validation group, post-RT ambulatory rates were 4%, 33%, 77% and 98%, respectively (p < 0.001).CONCLUSIONS: Patients achieving 19-25 points had very poor functional outcomes and survival, and may receive single-fraction RT for pain relief. Selected patients with 26-34 points may benefit from additional surgery. Patients achieving ≥35 points achieved favorable results after RT alone.

AB - BACKGROUND: This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients.METHODS: 1,129 elderly patients (≥65 years) were assigned to the test (N = 565) or validation group (N = 564). In the test group, nine pre-treatment factors (age, gender, tumor type, number of involved vertebrae, pre-RT ambulatory status, other bone metastases, visceral metastases, interval cancer diagnosis to RT, time developing motor deficits) and fractionation regimen were investigated. Factors significantly associated with post-RT ambulatory status on multivariate analysis were included in the score. The score for each factor was determined by dividing the post-RT ambulatory rate at 1 month (%) by 10. The total score represented the sum of these scores.RESULTS: In the multivariate analysis of the test group, age, primary tumor type, pre-RT ambulatory status, visceral metastases, and time developing motor deficits were significantly associated with post-RT ambulatory status. Total scores were 19 to 41 points. In the test group, post-RT ambulatory rates were 5% for 19-25 points, 35% for 26-30 points, 80% for 31-34 points, and 98% for 35-41 points (p < 0.001). 6-month survival rates were 11%, 21%, 59% and 76%, respectively. In the validation group, post-RT ambulatory rates were 4%, 33%, 77% and 98%, respectively (p < 0.001).CONCLUSIONS: Patients achieving 19-25 points had very poor functional outcomes and survival, and may receive single-fraction RT for pain relief. Selected patients with 26-34 points may benefit from additional surgery. Patients achieving ≥35 points achieved favorable results after RT alone.

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Humans

KW - Male

KW - Multivariate Analysis

KW - Prognosis

KW - Risk Assessment

KW - Spinal Cord Compression

KW - Spinal Neoplasms

KW - Survival Analysis

KW - Walking

U2 - 10.1186/1471-2407-14-589

DO - 10.1186/1471-2407-14-589

M3 - SCORING: Journal article

C2 - 25123656

VL - 14

SP - 589

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

ER -