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A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy

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A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy. / Adam, Meike; Hannah, Amir; Budäus, Lars; Steuber, Thomas; Salomon, Georg; Michl, Uwe; Haese, Alexander; Fisch, Margit; Wittmer, Corinna; Steurer, Stefan; Minner, Sarah; Heinzer, Hans; Huland, Hartwig; Graefen, Markus; Sauter, Guido; Schlomm, Thorsten; Isbarn, Hendrik.

In: J UROLOGY, Vol. 192, No. 1, 08.02.2014, p. 97-101.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Adam, M, Hannah, A, Budäus, L, Steuber, T, Salomon, G, Michl, U, Haese, A, Fisch, M, Wittmer, C, Steurer, S, Minner, S, Heinzer, H, Huland, H, Graefen, M, Sauter, G, Schlomm, T & Isbarn, H 2014, 'A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy', J UROLOGY, vol. 192, no. 1, pp. 97-101. https://doi.org/10.1016/j.juro.2014.01.029

APA

Adam, M., Hannah, A., Budäus, L., Steuber, T., Salomon, G., Michl, U., Haese, A., Fisch, M., Wittmer, C., Steurer, S., Minner, S., Heinzer, H., Huland, H., Graefen, M., Sauter, G., Schlomm, T., & Isbarn, H. (2014). A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy. J UROLOGY, 192(1), 97-101. https://doi.org/10.1016/j.juro.2014.01.029

Vancouver

Adam M, Hannah A, Budäus L, Steuber T, Salomon G, Michl U et al. A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy. J UROLOGY. 2014 Feb 8;192(1):97-101. https://doi.org/10.1016/j.juro.2014.01.029

Bibtex

@article{a27e968910f74148b82018097dc0c984,
title = "A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy",
abstract = "PURPOSE: The prognostic significance of a tertiary Gleason pattern in the radical prostatectomy specimen is controversial. We tested the impact of a tertiary Gleason pattern on adverse histopathological features and biochemical recurrence rates after radical prostatectomy.MATERIALS AND METHODS: We assessed data on 11,226 consecutive patients treated with radical prostatectomy at our institution between June 2007 and February 2013. We compared 2,396 patients with (22.4%) and 8,260 without (77.5%) a tertiary Gleason pattern for adverse histopathological features (extraprostatic extension, seminal vesicle invasion, positive surgical margins and lymph node invasion) using the chi-square test. The effect of a tertiary Gleason pattern on biochemical recurrence was tested in univariable and multivariable models. Subanalyses were then done for different radical prostatectomy Gleason groups (6 or less, 3 + 4 and 4 + 3).RESULTS: A tertiary Gleason pattern was statistically significantly associated with all evaluated histopathological parameters (each p <0.001). It was an independent predictor of biochemical recurrence (HR 1.43, p <0.001). On subanalysis only a tertiary Gleason pattern independently predicted biochemical recurrence in the patient cohort with a radical prostatectomy Gleason score of 3 + 4 and 4 + 3. However, it failed to attain independent predictor status in patients with a radical prostatectomy Gleason score of 6 or less.CONCLUSIONS: A tertiary Gleason pattern is a significant and independent predictor of biochemical recurrence after radical prostatectomy with the strongest prognostic effect in cases with Gleason scores 3 + 4 and 4 + 3. Therefore, a tertiary Gleason pattern should be recorded in the pathological report.",
author = "Meike Adam and Amir Hannah and Lars Bud{\"a}us and Thomas Steuber and Georg Salomon and Uwe Michl and Alexander Haese and Margit Fisch and Corinna Wittmer and Stefan Steurer and Sarah Minner and Hans Heinzer and Hartwig Huland and Markus Graefen and Guido Sauter and Thorsten Schlomm and Hendrik Isbarn",
note = "Copyright {\textcopyright} 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.",
year = "2014",
month = feb,
day = "8",
doi = "10.1016/j.juro.2014.01.029",
language = "English",
volume = "192",
pages = "97--101",
journal = "J UROLOGY",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - A Tertiary Gleason Pattern in the Prostatectomy Specimen and its Association with Adverse Outcome after Radical Prostatectomy

AU - Adam, Meike

AU - Hannah, Amir

AU - Budäus, Lars

AU - Steuber, Thomas

AU - Salomon, Georg

AU - Michl, Uwe

AU - Haese, Alexander

AU - Fisch, Margit

AU - Wittmer, Corinna

AU - Steurer, Stefan

AU - Minner, Sarah

AU - Heinzer, Hans

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Sauter, Guido

AU - Schlomm, Thorsten

AU - Isbarn, Hendrik

N1 - Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2014/2/8

Y1 - 2014/2/8

N2 - PURPOSE: The prognostic significance of a tertiary Gleason pattern in the radical prostatectomy specimen is controversial. We tested the impact of a tertiary Gleason pattern on adverse histopathological features and biochemical recurrence rates after radical prostatectomy.MATERIALS AND METHODS: We assessed data on 11,226 consecutive patients treated with radical prostatectomy at our institution between June 2007 and February 2013. We compared 2,396 patients with (22.4%) and 8,260 without (77.5%) a tertiary Gleason pattern for adverse histopathological features (extraprostatic extension, seminal vesicle invasion, positive surgical margins and lymph node invasion) using the chi-square test. The effect of a tertiary Gleason pattern on biochemical recurrence was tested in univariable and multivariable models. Subanalyses were then done for different radical prostatectomy Gleason groups (6 or less, 3 + 4 and 4 + 3).RESULTS: A tertiary Gleason pattern was statistically significantly associated with all evaluated histopathological parameters (each p <0.001). It was an independent predictor of biochemical recurrence (HR 1.43, p <0.001). On subanalysis only a tertiary Gleason pattern independently predicted biochemical recurrence in the patient cohort with a radical prostatectomy Gleason score of 3 + 4 and 4 + 3. However, it failed to attain independent predictor status in patients with a radical prostatectomy Gleason score of 6 or less.CONCLUSIONS: A tertiary Gleason pattern is a significant and independent predictor of biochemical recurrence after radical prostatectomy with the strongest prognostic effect in cases with Gleason scores 3 + 4 and 4 + 3. Therefore, a tertiary Gleason pattern should be recorded in the pathological report.

AB - PURPOSE: The prognostic significance of a tertiary Gleason pattern in the radical prostatectomy specimen is controversial. We tested the impact of a tertiary Gleason pattern on adverse histopathological features and biochemical recurrence rates after radical prostatectomy.MATERIALS AND METHODS: We assessed data on 11,226 consecutive patients treated with radical prostatectomy at our institution between June 2007 and February 2013. We compared 2,396 patients with (22.4%) and 8,260 without (77.5%) a tertiary Gleason pattern for adverse histopathological features (extraprostatic extension, seminal vesicle invasion, positive surgical margins and lymph node invasion) using the chi-square test. The effect of a tertiary Gleason pattern on biochemical recurrence was tested in univariable and multivariable models. Subanalyses were then done for different radical prostatectomy Gleason groups (6 or less, 3 + 4 and 4 + 3).RESULTS: A tertiary Gleason pattern was statistically significantly associated with all evaluated histopathological parameters (each p <0.001). It was an independent predictor of biochemical recurrence (HR 1.43, p <0.001). On subanalysis only a tertiary Gleason pattern independently predicted biochemical recurrence in the patient cohort with a radical prostatectomy Gleason score of 3 + 4 and 4 + 3. However, it failed to attain independent predictor status in patients with a radical prostatectomy Gleason score of 6 or less.CONCLUSIONS: A tertiary Gleason pattern is a significant and independent predictor of biochemical recurrence after radical prostatectomy with the strongest prognostic effect in cases with Gleason scores 3 + 4 and 4 + 3. Therefore, a tertiary Gleason pattern should be recorded in the pathological report.

U2 - 10.1016/j.juro.2014.01.029

DO - 10.1016/j.juro.2014.01.029

M3 - SCORING: Journal article

C2 - 24518778

VL - 192

SP - 97

EP - 101

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 1

ER -