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A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry

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A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry. / Selke, Stephanie; Winter, Martin; Finger, Susann; Roeher, K.; Neppert, Joana; Harth, Volker.

In: J CHROMATOGR B, Vol. 1231, 123923, 01.12.2023, p. 123923.

Research output: SCORING: Contribution to journal › Short publication › Research › peer-review

Harvard

Selke, S, Winter, M, Finger, S, Roeher, K, Neppert, J & Harth, V 2023, 'A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry', J CHROMATOGR B, vol. 1231, 123923, pp. 123923. https://doi.org/10.1016/j.jchromb.2023.123923

APA

Selke, S., Winter, M., Finger, S., Roeher, K., Neppert, J., & Harth, V. (2023). A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry. J CHROMATOGR B, 1231, 123923. [123923]. https://doi.org/10.1016/j.jchromb.2023.123923

Vancouver

Selke S, Winter M, Finger S, Roeher K, Neppert J, Harth V. A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry. J CHROMATOGR B. 2023 Dec 1;1231:123923. 123923. https://doi.org/10.1016/j.jchromb.2023.123923

Bibtex

@article{400d49f060ea4794bb47723363ae57a7,
title = "A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry",
abstract = "Biological monitoring of the unmodified sevoflurane and its metabolite hexafluoroisopropanol (HFIP) in urine samples was proposed to determine the individual exposure levels of the medical staff. In this study, a method for simultaneous determination of both compounds in urine using static headspace-gas chromatography-mass spectrometry (HS-GC-MS) was developed. The method is linear over a broad concentration range from 1 to 1000 µg/L (r2 > 0.999) and shows high precision. Limits of quantification (LOQ) are 0.6 µg/L for sevoflurane and 3 µg/L for HFIP, representing an excellent sensitivity without the necessity of analyte enrichment. The method was successfully applied in a German pilot-study to monitor both compounds in samples from medical personnel working in operating theatres. Urinary concentrations of HFIP ranged between < LOQ and 145 µg/L, while sevoflurane was below the LOD in all samples.",
author = "Stephanie Selke and Martin Winter and Susann Finger and K. Roeher and Joana Neppert and Volker Harth",
year = "2023",
month = dec,
day = "1",
doi = "10.1016/j.jchromb.2023.123923",
language = "English",
volume = "1231",
pages = "123923",
journal = "J CHROMATOGR B",
issn = "1570-0232",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A straightforward method for determination of the sevoflurane metabolite hexafluoroisopropanol in urinary occupational medical samples by headspace-gas chromatography mass spectrometry

AU - Selke, Stephanie

AU - Winter, Martin

AU - Finger, Susann

AU - Roeher, K.

AU - Neppert, Joana

AU - Harth, Volker

PY - 2023/12/1

Y1 - 2023/12/1

N2 - Biological monitoring of the unmodified sevoflurane and its metabolite hexafluoroisopropanol (HFIP) in urine samples was proposed to determine the individual exposure levels of the medical staff. In this study, a method for simultaneous determination of both compounds in urine using static headspace-gas chromatography-mass spectrometry (HS-GC-MS) was developed. The method is linear over a broad concentration range from 1 to 1000 µg/L (r2 > 0.999) and shows high precision. Limits of quantification (LOQ) are 0.6 µg/L for sevoflurane and 3 µg/L for HFIP, representing an excellent sensitivity without the necessity of analyte enrichment. The method was successfully applied in a German pilot-study to monitor both compounds in samples from medical personnel working in operating theatres. Urinary concentrations of HFIP ranged between < LOQ and 145 µg/L, while sevoflurane was below the LOD in all samples.

AB - Biological monitoring of the unmodified sevoflurane and its metabolite hexafluoroisopropanol (HFIP) in urine samples was proposed to determine the individual exposure levels of the medical staff. In this study, a method for simultaneous determination of both compounds in urine using static headspace-gas chromatography-mass spectrometry (HS-GC-MS) was developed. The method is linear over a broad concentration range from 1 to 1000 µg/L (r2 > 0.999) and shows high precision. Limits of quantification (LOQ) are 0.6 µg/L for sevoflurane and 3 µg/L for HFIP, representing an excellent sensitivity without the necessity of analyte enrichment. The method was successfully applied in a German pilot-study to monitor both compounds in samples from medical personnel working in operating theatres. Urinary concentrations of HFIP ranged between < LOQ and 145 µg/L, while sevoflurane was below the LOD in all samples.

U2 - 10.1016/j.jchromb.2023.123923

DO - 10.1016/j.jchromb.2023.123923

M3 - Short publication

C2 - 37984163

VL - 1231

SP - 123923

JO - J CHROMATOGR B

JF - J CHROMATOGR B

SN - 1570-0232

M1 - 123923

ER -