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A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells

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A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells. / Brandt, Anna; Matschke, Jakob; Fehrle, Wilfried; von Wenserski, Lisa; Bokemeyer, Carsten; Illerhaus, Gerald; Binder, Mascha.

In: LEUKEMIA LYMPHOMA, Vol. 60, No. 2, 02.2019, p. 334-340.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brandt, A, Matschke, J, Fehrle, W, von Wenserski, L, Bokemeyer, C, Illerhaus, G & Binder, M 2019, 'A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells', LEUKEMIA LYMPHOMA, vol. 60, no. 2, pp. 334-340. https://doi.org/10.1080/10428194.2018.1482538

APA

Brandt, A., Matschke, J., Fehrle, W., von Wenserski, L., Bokemeyer, C., Illerhaus, G., & Binder, M. (2019). A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells. LEUKEMIA LYMPHOMA, 60(2), 334-340. https://doi.org/10.1080/10428194.2018.1482538

Vancouver

Brandt A, Matschke J, Fehrle W, von Wenserski L, Bokemeyer C, Illerhaus G et al. A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells. LEUKEMIA LYMPHOMA. 2019 Feb;60(2):334-340. https://doi.org/10.1080/10428194.2018.1482538

Bibtex

@article{5f69797dcb214f3bb94bbfdd13e7e7e2,
title = "A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells",
abstract = "Clonal bone marrow (BM) B-cell populations are a common finding in patients with suspected primary central nervous system lymphoma (PCNSL). To assess their clinical significance, benign monoclonal B-cell lymphocytosis (MBL) needs to be differentiated from concomitant BM involvement, since patients with secondary central nervous system lymphoma (SCNSL) generally require more intensive treatment directed also at the component outside the central nervous system (CNS). Here, we retrospectively analyzed BM samplings in 51 patients with suspected PCNSL. We found clonal B cell populations in 8 of 51 cases (16%) by flow cytometry. None of these eight cases had BM involvement by high-grade lymphoma. No lymphoma relapses outside the CNS were recorded. Together, our data points at a significant percentage of patients with suspected PCNSL harboring clonal BM B-cells, which in this patient group always represented benign MBL. Failure to differentiate these populations from systemic lymphoma involvement may result in overtreatment of patients.",
author = "Anna Brandt and Jakob Matschke and Wilfried Fehrle and {von Wenserski}, Lisa and Carsten Bokemeyer and Gerald Illerhaus and Mascha Binder",
year = "2019",
month = feb,
doi = "10.1080/10428194.2018.1482538",
language = "English",
volume = "60",
pages = "334--340",
journal = "LEUKEMIA LYMPHOMA",
issn = "1042-8194",
publisher = "informa healthcare",
number = "2",

}

RIS

TY - JOUR

T1 - A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells

AU - Brandt, Anna

AU - Matschke, Jakob

AU - Fehrle, Wilfried

AU - von Wenserski, Lisa

AU - Bokemeyer, Carsten

AU - Illerhaus, Gerald

AU - Binder, Mascha

PY - 2019/2

Y1 - 2019/2

N2 - Clonal bone marrow (BM) B-cell populations are a common finding in patients with suspected primary central nervous system lymphoma (PCNSL). To assess their clinical significance, benign monoclonal B-cell lymphocytosis (MBL) needs to be differentiated from concomitant BM involvement, since patients with secondary central nervous system lymphoma (SCNSL) generally require more intensive treatment directed also at the component outside the central nervous system (CNS). Here, we retrospectively analyzed BM samplings in 51 patients with suspected PCNSL. We found clonal B cell populations in 8 of 51 cases (16%) by flow cytometry. None of these eight cases had BM involvement by high-grade lymphoma. No lymphoma relapses outside the CNS were recorded. Together, our data points at a significant percentage of patients with suspected PCNSL harboring clonal BM B-cells, which in this patient group always represented benign MBL. Failure to differentiate these populations from systemic lymphoma involvement may result in overtreatment of patients.

AB - Clonal bone marrow (BM) B-cell populations are a common finding in patients with suspected primary central nervous system lymphoma (PCNSL). To assess their clinical significance, benign monoclonal B-cell lymphocytosis (MBL) needs to be differentiated from concomitant BM involvement, since patients with secondary central nervous system lymphoma (SCNSL) generally require more intensive treatment directed also at the component outside the central nervous system (CNS). Here, we retrospectively analyzed BM samplings in 51 patients with suspected PCNSL. We found clonal B cell populations in 8 of 51 cases (16%) by flow cytometry. None of these eight cases had BM involvement by high-grade lymphoma. No lymphoma relapses outside the CNS were recorded. Together, our data points at a significant percentage of patients with suspected PCNSL harboring clonal BM B-cells, which in this patient group always represented benign MBL. Failure to differentiate these populations from systemic lymphoma involvement may result in overtreatment of patients.

U2 - 10.1080/10428194.2018.1482538

DO - 10.1080/10428194.2018.1482538

M3 - SCORING: Journal article

C2 - 30033830

VL - 60

SP - 334

EP - 340

JO - LEUKEMIA LYMPHOMA

JF - LEUKEMIA LYMPHOMA

SN - 1042-8194

IS - 2

ER -