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A side by side comparison of cytology and biomarkers for bladder cancer detection.

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A side by side comparison of cytology and biomarkers for bladder cancer detection. / Schroeder, Grethchen L; Lorenzo-Gomez, Maria-Fernanda; Hautmann, Stefan H; Friedrich, Martin; Ekici, Sinan; Huland, Hartwig; Lokeshwar, Vinata.

In: J UROLOGY, Vol. 172, No. 3, 3, 2004, p. 1123-1126.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schroeder, GL, Lorenzo-Gomez, M-F, Hautmann, SH, Friedrich, M, Ekici, S, Huland, H & Lokeshwar, V 2004, 'A side by side comparison of cytology and biomarkers for bladder cancer detection.', J UROLOGY, vol. 172, no. 3, 3, pp. 1123-1126. <http://www.ncbi.nlm.nih.gov/pubmed/15311054?dopt=Citation>

APA

Schroeder, G. L., Lorenzo-Gomez, M-F., Hautmann, S. H., Friedrich, M., Ekici, S., Huland, H., & Lokeshwar, V. (2004). A side by side comparison of cytology and biomarkers for bladder cancer detection. J UROLOGY, 172(3), 1123-1126. [3]. http://www.ncbi.nlm.nih.gov/pubmed/15311054?dopt=Citation

Vancouver

Schroeder GL, Lorenzo-Gomez M-F, Hautmann SH, Friedrich M, Ekici S, Huland H et al. A side by side comparison of cytology and biomarkers for bladder cancer detection. J UROLOGY. 2004;172(3):1123-1126. 3.

Bibtex

@article{2ee9316706d84b898d61311486be0b57,
title = "A side by side comparison of cytology and biomarkers for bladder cancer detection.",
abstract = "PURPOSE: The identification of accurate bladder tumor markers/tests could improve diagnosis, recurrence monitoring and treatment in patients with bladder cancer. In this study we compared the efficacy of the hyaluronic acid (HA)-hyaluronidase (HAase), BTA-Stat (Bard/Bion Diagnostics, Redmond, Washington), Hemastix (Bayer Corp., Elkhart, Indiana) (hematuria detection) and UBC-Rapid (IDL Biotech, Borl{\"a}nger, Sweden) tests, and cytology to detect bladder cancer. The HA-HAase test measures urinary HA and HAase levels, BTA-Stat detects complement factor-H and H related protein in urine, the Hemastix hemoglobin dipstick detects hematuria and UBC-Rapid detects cytokeratin 8 and 18 fragments in urine. MATERIALS AND METHODS: A total of 138 urine specimens from 115 patients were collected at University Hospital Hamburg-Eppendorf, including 59 with active bladder cancer and 79 with a history of bladder cancer (73) or with benign genitourinary conditions (6). Specimens were assayed by the HA-HAase test, BTA-Stat, Hemastix (hemoglobin dipstick) and UBC-Rapid. Cystoscopy and histological findings were used to make the clinical diagnosis. Cytology results were available on 92 patients. RESULTS: In a side by side comparison the HA-HAase test, cytology, BTA-Stat, Hemastix and UBC-Rapid had 88.1%, 70.6%, 52.5%, 50.8% and 35.6% sensitivity, and 81%, 81%, 76.7%, 78.2% and 75% specificity, respectively. The accuracy, and negative and positive predictive values of the HA-HAase test were the highest (84.1%, 90.1% and 77.6%), followed by cytology (77.2%, 82.5% and 68.6%), Hemastix (66.4%, 67.8% and 63.8%), BTA-Stat (66.2%, 67.8% and 63.3%) and UBC-Rapid (57.8%, 60% and 52.5%), respectively. CONCLUSIONS:: The HA-HAase test is superior to cytology, BTA-Stat, Hemastix and UBC-Rapid for detecting bladder cancer recurrence. A side-by-side comparison of tumor markers should help identify a marker for monitoring bladder cancer recurrence.",
author = "Schroeder, {Grethchen L} and Maria-Fernanda Lorenzo-Gomez and Hautmann, {Stefan H} and Martin Friedrich and Sinan Ekici and Hartwig Huland and Vinata Lokeshwar",
year = "2004",
language = "Deutsch",
volume = "172",
pages = "1123--1126",
journal = "J UROLOGY",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - A side by side comparison of cytology and biomarkers for bladder cancer detection.

AU - Schroeder, Grethchen L

AU - Lorenzo-Gomez, Maria-Fernanda

AU - Hautmann, Stefan H

AU - Friedrich, Martin

AU - Ekici, Sinan

AU - Huland, Hartwig

AU - Lokeshwar, Vinata

PY - 2004

Y1 - 2004

N2 - PURPOSE: The identification of accurate bladder tumor markers/tests could improve diagnosis, recurrence monitoring and treatment in patients with bladder cancer. In this study we compared the efficacy of the hyaluronic acid (HA)-hyaluronidase (HAase), BTA-Stat (Bard/Bion Diagnostics, Redmond, Washington), Hemastix (Bayer Corp., Elkhart, Indiana) (hematuria detection) and UBC-Rapid (IDL Biotech, Borlänger, Sweden) tests, and cytology to detect bladder cancer. The HA-HAase test measures urinary HA and HAase levels, BTA-Stat detects complement factor-H and H related protein in urine, the Hemastix hemoglobin dipstick detects hematuria and UBC-Rapid detects cytokeratin 8 and 18 fragments in urine. MATERIALS AND METHODS: A total of 138 urine specimens from 115 patients were collected at University Hospital Hamburg-Eppendorf, including 59 with active bladder cancer and 79 with a history of bladder cancer (73) or with benign genitourinary conditions (6). Specimens were assayed by the HA-HAase test, BTA-Stat, Hemastix (hemoglobin dipstick) and UBC-Rapid. Cystoscopy and histological findings were used to make the clinical diagnosis. Cytology results were available on 92 patients. RESULTS: In a side by side comparison the HA-HAase test, cytology, BTA-Stat, Hemastix and UBC-Rapid had 88.1%, 70.6%, 52.5%, 50.8% and 35.6% sensitivity, and 81%, 81%, 76.7%, 78.2% and 75% specificity, respectively. The accuracy, and negative and positive predictive values of the HA-HAase test were the highest (84.1%, 90.1% and 77.6%), followed by cytology (77.2%, 82.5% and 68.6%), Hemastix (66.4%, 67.8% and 63.8%), BTA-Stat (66.2%, 67.8% and 63.3%) and UBC-Rapid (57.8%, 60% and 52.5%), respectively. CONCLUSIONS:: The HA-HAase test is superior to cytology, BTA-Stat, Hemastix and UBC-Rapid for detecting bladder cancer recurrence. A side-by-side comparison of tumor markers should help identify a marker for monitoring bladder cancer recurrence.

AB - PURPOSE: The identification of accurate bladder tumor markers/tests could improve diagnosis, recurrence monitoring and treatment in patients with bladder cancer. In this study we compared the efficacy of the hyaluronic acid (HA)-hyaluronidase (HAase), BTA-Stat (Bard/Bion Diagnostics, Redmond, Washington), Hemastix (Bayer Corp., Elkhart, Indiana) (hematuria detection) and UBC-Rapid (IDL Biotech, Borlänger, Sweden) tests, and cytology to detect bladder cancer. The HA-HAase test measures urinary HA and HAase levels, BTA-Stat detects complement factor-H and H related protein in urine, the Hemastix hemoglobin dipstick detects hematuria and UBC-Rapid detects cytokeratin 8 and 18 fragments in urine. MATERIALS AND METHODS: A total of 138 urine specimens from 115 patients were collected at University Hospital Hamburg-Eppendorf, including 59 with active bladder cancer and 79 with a history of bladder cancer (73) or with benign genitourinary conditions (6). Specimens were assayed by the HA-HAase test, BTA-Stat, Hemastix (hemoglobin dipstick) and UBC-Rapid. Cystoscopy and histological findings were used to make the clinical diagnosis. Cytology results were available on 92 patients. RESULTS: In a side by side comparison the HA-HAase test, cytology, BTA-Stat, Hemastix and UBC-Rapid had 88.1%, 70.6%, 52.5%, 50.8% and 35.6% sensitivity, and 81%, 81%, 76.7%, 78.2% and 75% specificity, respectively. The accuracy, and negative and positive predictive values of the HA-HAase test were the highest (84.1%, 90.1% and 77.6%), followed by cytology (77.2%, 82.5% and 68.6%), Hemastix (66.4%, 67.8% and 63.8%), BTA-Stat (66.2%, 67.8% and 63.3%) and UBC-Rapid (57.8%, 60% and 52.5%), respectively. CONCLUSIONS:: The HA-HAase test is superior to cytology, BTA-Stat, Hemastix and UBC-Rapid for detecting bladder cancer recurrence. A side-by-side comparison of tumor markers should help identify a marker for monitoring bladder cancer recurrence.

M3 - SCORING: Zeitschriftenaufsatz

VL - 172

SP - 1123

EP - 1126

JO - J UROLOGY

JF - J UROLOGY

SN - 0022-5347

IS - 3

M1 - 3

ER -