A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook
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A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook. / Kramvis, Anna; Chang, Kyong-Mi; Dandri, Maura; Farci, Patrizia; Glebe, Dieter; Hu, Jianming; Janssen, Harry L A; Lau, Daryl T Y; Penicaud, Capucine; Pollicino, Teresa; Testoni, Barbara; Van Bömmel, Florian; Andrisani, Ourania; Beumont-Mauviel, Maria; Block, Timothy M; Chan, Henry L Y; Cloherty, Gavin A; Delaney, William E; Geretti, Anna Maria; Gehring, Adam; Jackson, Kathy; Lenz, Oliver; Maini, Mala K; Miller, Veronica; Protzer, Ulrike; Yang, Jenny C; Yuen, Man-Fung; Zoulim, Fabien; Revill, Peter A.
In: NAT REV GASTRO HEPAT, Vol. 19, No. 11, 11.2022, p. 727-745.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook
AU - Kramvis, Anna
AU - Chang, Kyong-Mi
AU - Dandri, Maura
AU - Farci, Patrizia
AU - Glebe, Dieter
AU - Hu, Jianming
AU - Janssen, Harry L A
AU - Lau, Daryl T Y
AU - Penicaud, Capucine
AU - Pollicino, Teresa
AU - Testoni, Barbara
AU - Van Bömmel, Florian
AU - Andrisani, Ourania
AU - Beumont-Mauviel, Maria
AU - Block, Timothy M
AU - Chan, Henry L Y
AU - Cloherty, Gavin A
AU - Delaney, William E
AU - Geretti, Anna Maria
AU - Gehring, Adam
AU - Jackson, Kathy
AU - Lenz, Oliver
AU - Maini, Mala K
AU - Miller, Veronica
AU - Protzer, Ulrike
AU - Yang, Jenny C
AU - Yuen, Man-Fung
AU - Zoulim, Fabien
AU - Revill, Peter A
N1 - © 2022. Springer Nature Limited.
PY - 2022/11
Y1 - 2022/11
N2 - Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one million people die annually from HBV-related causes, including liver cancer. Although there is a preventative vaccine and antiviral therapies suppressing HBV replication, there is no cure. Intensive efforts are under way to develop curative HBV therapies. Currently, only a few biomarkers are available for monitoring or predicting HBV disease progression and treatment response. As new therapies become available, new biomarkers to monitor viral and host responses are urgently needed. In October 2020, the International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) held a virtual and interactive workshop on HBV biomarkers endorsed by the International HBV Meeting. Various stakeholders from academia, clinical practice and the pharmaceutical industry, with complementary expertise, presented and participated in panel discussions. The clinical utility of both classic and emerging viral and immunological serum biomarkers with respect to the course of infection, disease progression, and response to current and emerging treatments was appraised. The latest advances were discussed, and knowledge gaps in understanding and interpretation of HBV biomarkers were identified. This Roadmap summarizes the strengths, weaknesses, opportunities and challenges of HBV biomarkers.
AB - Globally, 296 million people are infected with hepatitis B virus (HBV), and approximately one million people die annually from HBV-related causes, including liver cancer. Although there is a preventative vaccine and antiviral therapies suppressing HBV replication, there is no cure. Intensive efforts are under way to develop curative HBV therapies. Currently, only a few biomarkers are available for monitoring or predicting HBV disease progression and treatment response. As new therapies become available, new biomarkers to monitor viral and host responses are urgently needed. In October 2020, the International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) held a virtual and interactive workshop on HBV biomarkers endorsed by the International HBV Meeting. Various stakeholders from academia, clinical practice and the pharmaceutical industry, with complementary expertise, presented and participated in panel discussions. The clinical utility of both classic and emerging viral and immunological serum biomarkers with respect to the course of infection, disease progression, and response to current and emerging treatments was appraised. The latest advances were discussed, and knowledge gaps in understanding and interpretation of HBV biomarkers were identified. This Roadmap summarizes the strengths, weaknesses, opportunities and challenges of HBV biomarkers.
KW - Humans
KW - Hepatitis B virus
KW - Hepatitis B, Chronic/diagnosis
KW - Antiviral Agents/therapeutic use
KW - Virus Replication
KW - Biomarkers
KW - Disease Progression
KW - Hepatitis B/diagnosis
U2 - 10.1038/s41575-022-00649-z
DO - 10.1038/s41575-022-00649-z
M3 - SCORING: Review article
C2 - 35859026
VL - 19
SP - 727
EP - 745
JO - NAT REV GASTRO HEPAT
JF - NAT REV GASTRO HEPAT
SN - 1759-5045
IS - 11
ER -