A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family

Thomas M C Binder; Reinhard Kelsch; Julia M Wikner; Lilian Aly; Cornelia Brendel; Ina Alster; Peter Kühnl; Ulrich Finckh; Thomas H Eiermann

doi:10.1016/j.humimm.2015.01.016

A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family

Standard

A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family. / Binder, Thomas M C; Kelsch, Reinhard; Wikner, Julia M; Aly, Lilian; Brendel, Cornelia; Alster, Ina; Kühnl, Peter; Finckh, Ulrich; Eiermann, Thomas H.

In: HUM IMMUNOL, Vol. 76, No. 2-3, 01.03.2015, p. 124-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Binder, TMC, Kelsch, R, Wikner, JM, Aly, L, Brendel, C, Alster, I, Kühnl, P, Finckh, U & Eiermann, TH 2015, 'A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family', HUM IMMUNOL, vol. 76, no. 2-3, pp. 124-8. https://doi.org/10.1016/j.humimm.2015.01.016

APA

Binder, T. M. C., Kelsch, R., Wikner, J. M., Aly, L., Brendel, C., Alster, I., Kühnl, P., Finckh, U., & Eiermann, T. H. (2015). A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family. HUM IMMUNOL, 76(2-3), 124-8. https://doi.org/10.1016/j.humimm.2015.01.016

Vancouver

Binder TMC, Kelsch R, Wikner JM, Aly L, Brendel C, Alster I et al. A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family. HUM IMMUNOL. 2015 Mar 1;76(2-3):124-8. https://doi.org/10.1016/j.humimm.2015.01.016

Bibtex

@article{f6128ff95c8b4b4ea686f4f2efe5756e,

title = "A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family",

abstract = "The HLA-DR and -DQ loci are close neighbors on chromosome 6 that are highly linked. Many common associations between HLA-DR and DQ-alleles are known, normally transmitted as HLA-D{\~R}DQ haplotypes from one generation to another. Reports of very recent genetic rearrangements between HLA-DR and -DQ are rarely found in the literature. In Europeans haplotypes containing DRB1(∗)15:01, DQB1(∗)02:01, and DQA1(∗)05:01 have not been reported before. We report the finding of the rare HLA haplotype A(∗)24:0{\~2}C(∗)07:0{\~2}B(∗)07:0{\~2}MICA(∗)008:0{\~1}DRB5(∗)01:0{\~1}DRB1(∗)15:0{\~1}DQA1(∗)05:0{\~1}DQB1(∗)02:0{\~1}DPB1(∗)04:01 in a German stem cell donor with East Frisian ancestry. Our observation suggests a rare ancestral recombination between the DR and DQ loci. In order to investigate this haplotype, we typed 50/74 members of the family encompassing four generations for HLA classes I and II by serological and molecular methods. The rare haplotype was identified in 12 heterozygous carriers. Furthermore, we identified and further characterized a putative crossing over event resulting in its reversion to a common haplotype.",

author = "Binder, {Thomas M C} and Reinhard Kelsch and Wikner, {Julia M} and Lilian Aly and Cornelia Brendel and Ina Alster and Peter K{\"u}hnl and Ulrich Finckh and Eiermann, {Thomas H}",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/j.humimm.2015.01.016",

language = "English",

volume = "76",

pages = "124--8",

journal = "HUM IMMUNOL",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "2-3",

}

RIS

TY - JOUR

T1 - A rare ancestral HLA-DRB1∗15:01~DQB1∗02:01 haplotype and its reversion in the same Western European family

AU - Binder, Thomas M C

AU - Kelsch, Reinhard

AU - Wikner, Julia M

AU - Aly, Lilian

AU - Brendel, Cornelia

AU - Alster, Ina

AU - Kühnl, Peter

AU - Finckh, Ulrich

AU - Eiermann, Thomas H

PY - 2015/3/1

Y1 - 2015/3/1

N2 - The HLA-DR and -DQ loci are close neighbors on chromosome 6 that are highly linked. Many common associations between HLA-DR and DQ-alleles are known, normally transmitted as HLA-DR̃DQ haplotypes from one generation to another. Reports of very recent genetic rearrangements between HLA-DR and -DQ are rarely found in the literature. In Europeans haplotypes containing DRB1(∗)15:01, DQB1(∗)02:01, and DQA1(∗)05:01 have not been reported before. We report the finding of the rare HLA haplotype A(∗)24:02̃C(∗)07:02̃B(∗)07:02̃MICA(∗)008:01̃DRB5(∗)01:01̃DRB1(∗)15:01̃DQA1(∗)05:01̃DQB1(∗)02:01̃DPB1(∗)04:01 in a German stem cell donor with East Frisian ancestry. Our observation suggests a rare ancestral recombination between the DR and DQ loci. In order to investigate this haplotype, we typed 50/74 members of the family encompassing four generations for HLA classes I and II by serological and molecular methods. The rare haplotype was identified in 12 heterozygous carriers. Furthermore, we identified and further characterized a putative crossing over event resulting in its reversion to a common haplotype.

AB - The HLA-DR and -DQ loci are close neighbors on chromosome 6 that are highly linked. Many common associations between HLA-DR and DQ-alleles are known, normally transmitted as HLA-DR̃DQ haplotypes from one generation to another. Reports of very recent genetic rearrangements between HLA-DR and -DQ are rarely found in the literature. In Europeans haplotypes containing DRB1(∗)15:01, DQB1(∗)02:01, and DQA1(∗)05:01 have not been reported before. We report the finding of the rare HLA haplotype A(∗)24:02̃C(∗)07:02̃B(∗)07:02̃MICA(∗)008:01̃DRB5(∗)01:01̃DRB1(∗)15:01̃DQA1(∗)05:01̃DQB1(∗)02:01̃DPB1(∗)04:01 in a German stem cell donor with East Frisian ancestry. Our observation suggests a rare ancestral recombination between the DR and DQ loci. In order to investigate this haplotype, we typed 50/74 members of the family encompassing four generations for HLA classes I and II by serological and molecular methods. The rare haplotype was identified in 12 heterozygous carriers. Furthermore, we identified and further characterized a putative crossing over event resulting in its reversion to a common haplotype.

U2 - 10.1016/j.humimm.2015.01.016

DO - 10.1016/j.humimm.2015.01.016

M3 - SCORING: Journal article

C2 - 25636575

VL - 76

SP - 124

EP - 128

JO - HUM IMMUNOL

JF - HUM IMMUNOL

SN - 0198-8859

IS - 2-3

ER -