A Protocol for Rat Kidney Normothermic Machine Perfusion and Subsequent Transplantation
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A Protocol for Rat Kidney Normothermic Machine Perfusion and Subsequent Transplantation. / Czogalla, Jan; Grahammer, Florian; Puelles, Victor G; Huber, Tobias B.
In: ARTIF ORGANS, Vol. 45, No. 2, 02.2021, p. 168-174.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - A Protocol for Rat Kidney Normothermic Machine Perfusion and Subsequent Transplantation
AU - Czogalla, Jan
AU - Grahammer, Florian
AU - Puelles, Victor G
AU - Huber, Tobias B
N1 - © 2020 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation and Wiley Periodicals LLC.
PY - 2021/2
Y1 - 2021/2
N2 - End-stage renal disease is a major global health burden. The only definitive treatment existing is renal transplantation. Worldwide, the demand for donated kidneys by far exceeds the supply. A novel technique for organ preservation, normothermic machine perfusion (NMP), now promises to increase the potential pool of available organs by extending the spectrum of donors and reducing the incidence of graft failure. First studies in humans and large animals are being performed with promising results, but refinement of the technique, buffer, and machines involved is labor-intensive and expensive. To our knowledge, this is the first report of a small animal model of NMP and subsequent transplantation.
AB - End-stage renal disease is a major global health burden. The only definitive treatment existing is renal transplantation. Worldwide, the demand for donated kidneys by far exceeds the supply. A novel technique for organ preservation, normothermic machine perfusion (NMP), now promises to increase the potential pool of available organs by extending the spectrum of donors and reducing the incidence of graft failure. First studies in humans and large animals are being performed with promising results, but refinement of the technique, buffer, and machines involved is labor-intensive and expensive. To our knowledge, this is the first report of a small animal model of NMP and subsequent transplantation.
U2 - 10.1111/aor.13799
DO - 10.1111/aor.13799
M3 - SCORING: Journal article
C2 - 32780541
VL - 45
SP - 168
EP - 174
JO - ARTIF ORGANS
JF - ARTIF ORGANS
SN - 0160-564X
IS - 2
ER -