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A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker

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A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker. / Schwarzl, Michael; Alogna, Alessio; Zweiker, David; Verderber, Jochen; Huber, Stefan; Manninger, Martin; Scherr, Daniel; Antoons, Gudrun; Pieske, Burkert M; Post, Heiner; Lueger, Andreas.

In: J ELECTROCARDIOL, Vol. 49, No. 2, 25.01.2016, p. 124-31.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schwarzl, M, Alogna, A, Zweiker, D, Verderber, J, Huber, S, Manninger, M, Scherr, D, Antoons, G, Pieske, BM, Post, H & Lueger, A 2016, 'A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker', J ELECTROCARDIOL, vol. 49, no. 2, pp. 124-31. https://doi.org/10.1016/j.jelectrocard.2015.12.012

APA

Schwarzl, M., Alogna, A., Zweiker, D., Verderber, J., Huber, S., Manninger, M., Scherr, D., Antoons, G., Pieske, B. M., Post, H., & Lueger, A. (2016). A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker. J ELECTROCARDIOL, 49(2), 124-31. https://doi.org/10.1016/j.jelectrocard.2015.12.012

Vancouver

Schwarzl M, Alogna A, Zweiker D, Verderber J, Huber S, Manninger M et al. A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker. J ELECTROCARDIOL. 2016 Jan 25;49(2):124-31. https://doi.org/10.1016/j.jelectrocard.2015.12.012

Bibtex

@article{204afb2bdbeb4fb7a8733cd570caadc6,
title = "A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker",
abstract = "Mechanisms underlying atrial remodeling toward atrial fibrillation (AF) are incompletely understood. We induced AF in 16 pigs by 6weeks of rapid atrial pacing (RAP, 600bpm) using a custom-built, telemetrically controlled pacemaker. AF evolution was monitored three times per week telemetrically in unstressed, conscious animals. We established a dose-response relationship between RAP duration and occurrence of sustained AF >60minutes. Left atrial (LA) dilatation was present already at 2weeks of RAP. There was no evidence of left ventricular heart failure after 6weeks of RAP. As a proof-of-principle, arterial hypertension was induced in 5/16 animals by implanting desoxycorticosterone acetate (DOCA, an aldosterone-analog) subcutaneously to accelerate atrial remodeling. RAP+DOCA resulted in increased AF stability with earlier onset of sustained AF and accelerated anatomical atrial remodeling with more pronounced LA dilatation. This novel porcine model can serve to characterize effects of maladaptive stimuli or protective interventions specifically during early AF. ",
keywords = "Animals, Atrial Fibrillation/diagnosis, Disease Models, Animal, Equipment Design, Equipment Failure Analysis, Female, Pacemaker, Artificial, Prostheses and Implants, Swine, Telemetry/instrumentation",
author = "Michael Schwarzl and Alessio Alogna and David Zweiker and Jochen Verderber and Stefan Huber and Martin Manninger and Daniel Scherr and Gudrun Antoons and Pieske, {Burkert M} and Heiner Post and Andreas Lueger",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = jan,
day = "25",
doi = "10.1016/j.jelectrocard.2015.12.012",
language = "English",
volume = "49",
pages = "124--31",
journal = "J ELECTROCARDIOL",
issn = "0022-0736",
publisher = "Churchill Livingstone",
number = "2",

}

RIS

TY - JOUR

T1 - A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker

AU - Schwarzl, Michael

AU - Alogna, Alessio

AU - Zweiker, David

AU - Verderber, Jochen

AU - Huber, Stefan

AU - Manninger, Martin

AU - Scherr, Daniel

AU - Antoons, Gudrun

AU - Pieske, Burkert M

AU - Post, Heiner

AU - Lueger, Andreas

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/1/25

Y1 - 2016/1/25

N2 - Mechanisms underlying atrial remodeling toward atrial fibrillation (AF) are incompletely understood. We induced AF in 16 pigs by 6weeks of rapid atrial pacing (RAP, 600bpm) using a custom-built, telemetrically controlled pacemaker. AF evolution was monitored three times per week telemetrically in unstressed, conscious animals. We established a dose-response relationship between RAP duration and occurrence of sustained AF >60minutes. Left atrial (LA) dilatation was present already at 2weeks of RAP. There was no evidence of left ventricular heart failure after 6weeks of RAP. As a proof-of-principle, arterial hypertension was induced in 5/16 animals by implanting desoxycorticosterone acetate (DOCA, an aldosterone-analog) subcutaneously to accelerate atrial remodeling. RAP+DOCA resulted in increased AF stability with earlier onset of sustained AF and accelerated anatomical atrial remodeling with more pronounced LA dilatation. This novel porcine model can serve to characterize effects of maladaptive stimuli or protective interventions specifically during early AF.

AB - Mechanisms underlying atrial remodeling toward atrial fibrillation (AF) are incompletely understood. We induced AF in 16 pigs by 6weeks of rapid atrial pacing (RAP, 600bpm) using a custom-built, telemetrically controlled pacemaker. AF evolution was monitored three times per week telemetrically in unstressed, conscious animals. We established a dose-response relationship between RAP duration and occurrence of sustained AF >60minutes. Left atrial (LA) dilatation was present already at 2weeks of RAP. There was no evidence of left ventricular heart failure after 6weeks of RAP. As a proof-of-principle, arterial hypertension was induced in 5/16 animals by implanting desoxycorticosterone acetate (DOCA, an aldosterone-analog) subcutaneously to accelerate atrial remodeling. RAP+DOCA resulted in increased AF stability with earlier onset of sustained AF and accelerated anatomical atrial remodeling with more pronounced LA dilatation. This novel porcine model can serve to characterize effects of maladaptive stimuli or protective interventions specifically during early AF.

KW - Animals

KW - Atrial Fibrillation/diagnosis

KW - Disease Models, Animal

KW - Equipment Design

KW - Equipment Failure Analysis

KW - Female

KW - Pacemaker, Artificial

KW - Prostheses and Implants

KW - Swine

KW - Telemetry/instrumentation

U2 - 10.1016/j.jelectrocard.2015.12.012

DO - 10.1016/j.jelectrocard.2015.12.012

M3 - SCORING: Journal article

C2 - 26803554

VL - 49

SP - 124

EP - 131

JO - J ELECTROCARDIOL

JF - J ELECTROCARDIOL

SN - 0022-0736

IS - 2

ER -