A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet.
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A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet. / Aberle, Jens; Evans, David; Beil, F U; Seedorf, U.
In: CLIN GENET, Vol. 68, No. 2, 2, 2005, p. 152-154.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet.
AU - Aberle, Jens
AU - Evans, David
AU - Beil, F U
AU - Seedorf, U
PY - 2005
Y1 - 2005
N2 - Apolipoprotein A5 is a recently discovered apolipoprotein involved primarily in triglyceride metabolism. Several single-nucleotide polymorphisms have been investigated since the initial report. The -1131T>C polymorphism has been associated with higher triglyceride levels and a decreased high-density lipoprotein cholesterol as well as with susceptibility to coronary heart disease. However, no study has so far emphasized on the association of a dietary intervention with apolipoprotein A5 polymorphisms. In a group of 606 hyperlipaemic and overweight men, we investigated how a short-term fat restriction affects lipid traits and body mass index (BMI) in wildtype and carriers of the -1131T>C polymorphism. Our result was that the reduction of BMI was significantly higher in C allele carriers (p=0.0021). Since the -1131T>C polymorphism predisposes to coronary heart disease, a restriction diet is an important therapeutic approach in -1131T>C carriers.
AB - Apolipoprotein A5 is a recently discovered apolipoprotein involved primarily in triglyceride metabolism. Several single-nucleotide polymorphisms have been investigated since the initial report. The -1131T>C polymorphism has been associated with higher triglyceride levels and a decreased high-density lipoprotein cholesterol as well as with susceptibility to coronary heart disease. However, no study has so far emphasized on the association of a dietary intervention with apolipoprotein A5 polymorphisms. In a group of 606 hyperlipaemic and overweight men, we investigated how a short-term fat restriction affects lipid traits and body mass index (BMI) in wildtype and carriers of the -1131T>C polymorphism. Our result was that the reduction of BMI was significantly higher in C allele carriers (p=0.0021). Since the -1131T>C polymorphism predisposes to coronary heart disease, a restriction diet is an important therapeutic approach in -1131T>C carriers.
M3 - SCORING: Zeitschriftenaufsatz
VL - 68
SP - 152
EP - 154
JO - CLIN GENET
JF - CLIN GENET
SN - 0009-9163
IS - 2
M1 - 2
ER -
