Research ExplorerPublicationsA pivotal role for galectin-1 in fetomaternal tolerance

A pivotal role for galectin-1 in fetomaternal tolerance

Standard

A pivotal role for galectin-1 in fetomaternal tolerance. / Blois, Sandra M; Ilarregui, Juan M; Tometten, Mareike; Garcia, Mariana; Orsal, Arif S; Cordo-Russo, Rosalia; Toscano, Marta A; Bianco, Germán A; Kobelt, Peter; Handjiski, Bori; Tirado, Irene; Markert, Udo R; Klapp, Burghard F; Poirier, Francoise; Szekeres-Bartho, Julia; Rabinovich, Gabriel A; Arck, Petra C.

In: NAT MED, Vol. 13, No. 12, 12.2007, p. 1450-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Blois, SM, Ilarregui, JM, Tometten, M, Garcia, M, Orsal, AS, Cordo-Russo, R, Toscano, MA, Bianco, GA, Kobelt, P, Handjiski, B, Tirado, I, Markert, UR, Klapp, BF, Poirier, F, Szekeres-Bartho, J, Rabinovich, GA & Arck, PC 2007, 'A pivotal role for galectin-1 in fetomaternal tolerance', NAT MED, vol. 13, no. 12, pp. 1450-7. https://doi.org/10.1038/nm1680

APA

Blois, S. M., Ilarregui, J. M., Tometten, M., Garcia, M., Orsal, A. S., Cordo-Russo, R., Toscano, M. A., Bianco, G. A., Kobelt, P., Handjiski, B., Tirado, I., Markert, U. R., Klapp, B. F., Poirier, F., Szekeres-Bartho, J., Rabinovich, G. A., & Arck, P. C. (2007). A pivotal role for galectin-1 in fetomaternal tolerance. NAT MED, 13(12), 1450-7. https://doi.org/10.1038/nm1680

Vancouver

Blois SM, Ilarregui JM, Tometten M, Garcia M, Orsal AS, Cordo-Russo R et al. A pivotal role for galectin-1 in fetomaternal tolerance. NAT MED. 2007 Dec;13(12):1450-7. https://doi.org/10.1038/nm1680

Bibtex

@article{0fadfb011b0443488d8ee1f6de21179b,
title = "A pivotal role for galectin-1 in fetomaternal tolerance",
abstract = "A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies.",
keywords = "Animals, CD4-Positive T-Lymphocytes/metabolism, Female, Galectin 1/genetics, Gene Expression Regulation, Developmental, Histocompatibility, Maternal-Fetal, Immune Tolerance, Interleukin-2 Receptor alpha Subunit/biosynthesis, Mice, Mice, Transgenic, Polysaccharides/chemistry, Pregnancy, Pregnancy, Animal, T-Lymphocytes, Regulatory/metabolism, Transplantation, Homologous",
author = "Blois, {Sandra M} and Ilarregui, {Juan M} and Mareike Tometten and Mariana Garcia and Orsal, {Arif S} and Rosalia Cordo-Russo and Toscano, {Marta A} and Bianco, {Germ{\'a}n A} and Peter Kobelt and Bori Handjiski and Irene Tirado and Markert, {Udo R} and Klapp, {Burghard F} and Francoise Poirier and Julia Szekeres-Bartho and Rabinovich, {Gabriel A} and Arck, {Petra C}",
year = "2007",
month = dec,
doi = "10.1038/nm1680",
language = "English",
volume = "13",
pages = "1450--7",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - A pivotal role for galectin-1 in fetomaternal tolerance

AU - Blois, Sandra M

AU - Ilarregui, Juan M

AU - Tometten, Mareike

AU - Garcia, Mariana

AU - Orsal, Arif S

AU - Cordo-Russo, Rosalia

AU - Toscano, Marta A

AU - Bianco, Germán A

AU - Kobelt, Peter

AU - Handjiski, Bori

AU - Tirado, Irene

AU - Markert, Udo R

AU - Klapp, Burghard F

AU - Poirier, Francoise

AU - Szekeres-Bartho, Julia

AU - Rabinovich, Gabriel A

AU - Arck, Petra C

PY - 2007/12

Y1 - 2007/12

N2 - A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies.

AB - A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies.

KW - Animals

KW - CD4-Positive T-Lymphocytes/metabolism

KW - Female

KW - Galectin 1/genetics

KW - Gene Expression Regulation, Developmental

KW - Histocompatibility, Maternal-Fetal

KW - Immune Tolerance

KW - Interleukin-2 Receptor alpha Subunit/biosynthesis

KW - Mice

KW - Mice, Transgenic

KW - Polysaccharides/chemistry

KW - Pregnancy

KW - Pregnancy, Animal

KW - T-Lymphocytes, Regulatory/metabolism

KW - Transplantation, Homologous

U2 - 10.1038/nm1680

DO - 10.1038/nm1680

M3 - SCORING: Journal article

C2 - 18026113

VL - 13

SP - 1450

EP - 1457

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 12

ER -