A novel, multi-level approach to assess allograft incorporation in revision total hip arthroplasty
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A novel, multi-level approach to assess allograft incorporation in revision total hip arthroplasty. / Rolvien, Tim; Friesecke, Christian; Butscheidt, Sebastian; Gehrke, Thorsten; Hahn, Michael; Püschel, Klaus.
In: SCI REP-UK, Vol. 10, No. 1, 16.09.2020, p. 15226.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - A novel, multi-level approach to assess allograft incorporation in revision total hip arthroplasty
AU - Rolvien, Tim
AU - Friesecke, Christian
AU - Butscheidt, Sebastian
AU - Gehrke, Thorsten
AU - Hahn, Michael
AU - Püschel, Klaus
PY - 2020/9/16
Y1 - 2020/9/16
N2 - The successful use of allografts in reconstructive orthopedic surgery, including revision total hip arthroplasty (THA), has been outlined repeatedly. Nonetheless, as previous studies were primarily based on clinical follow-ups, we aimed to create an algorithm that accurately determines the extent of allograft incorporation in the acetabulum and femur using a suite of high-resolution imaging techniques. This study is based on a large patient database including > 4,500 patient data with previous revision THA and simultaneous use of allografts. While the database was continuously matched with the deceased individuals at the local forensic medicine department, complete hips were retrieved in case of a positive match. A positive match was achieved for n = 46 hips at a mean follow-up of 11.8 ± 5.1 years. Comprehensive imaging included contact radiography, high-resolution computed tomography (HR-pQCT), undecalcified histology of ground sections and quantitative backscattered electron imaging (qBEI). We here define a histomorphometric toolkit of parameters to precisely characterize the incorporation of structural (bulk) and morselized (chip) allografts in the acetabulum (n = 38) and femur (n = 8), including the defect area and interface length, microstructural and cellular bone turnover parameters as well as overlap and fibrosis thickness. This collection of samples, through its unique study design and precise definition of incorporation parameters, will provide the scientific community with a valuable source for further in-depth investigation of allograft incorporation and, beyond that, the regenerative potential of this osteoconductive scaffold.
AB - The successful use of allografts in reconstructive orthopedic surgery, including revision total hip arthroplasty (THA), has been outlined repeatedly. Nonetheless, as previous studies were primarily based on clinical follow-ups, we aimed to create an algorithm that accurately determines the extent of allograft incorporation in the acetabulum and femur using a suite of high-resolution imaging techniques. This study is based on a large patient database including > 4,500 patient data with previous revision THA and simultaneous use of allografts. While the database was continuously matched with the deceased individuals at the local forensic medicine department, complete hips were retrieved in case of a positive match. A positive match was achieved for n = 46 hips at a mean follow-up of 11.8 ± 5.1 years. Comprehensive imaging included contact radiography, high-resolution computed tomography (HR-pQCT), undecalcified histology of ground sections and quantitative backscattered electron imaging (qBEI). We here define a histomorphometric toolkit of parameters to precisely characterize the incorporation of structural (bulk) and morselized (chip) allografts in the acetabulum (n = 38) and femur (n = 8), including the defect area and interface length, microstructural and cellular bone turnover parameters as well as overlap and fibrosis thickness. This collection of samples, through its unique study design and precise definition of incorporation parameters, will provide the scientific community with a valuable source for further in-depth investigation of allograft incorporation and, beyond that, the regenerative potential of this osteoconductive scaffold.
U2 - 10.1038/s41598-020-72257-3
DO - 10.1038/s41598-020-72257-3
M3 - SCORING: Journal article
C2 - 32939007
VL - 10
SP - 15226
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
ER -