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A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study

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A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study. / Schulte, Eva C; Kondofersky, Ivan; Budde, Monika; Papiol, Sergi; Senner, Fanny; Schaupp, Sabrina K; Reich-Erkelenz, Daniela; Klöhn-Saghatolislam, Farahnaz; Kalman, Janos L; Gade, Katrin; Hake, Maria; Comes, Ashley L; Anderson-Schmidt, Heike; Adorjan, Kristina; Juckel, Georg; Schmauß, Max; Zimmermann, Jörg; Reimer, Jens; Wiltfang, Jens; Reininghaus, Eva Z; Anghelescu, Ion-George; Konrad, Carsten; Figge, Christian; von Hagen, Martin; Jäger, Markus; Dietrich, Detlef E; Spitzer, Carsten; Witt, Stephanie H; Forstner, Andreas J; Rietschel, Marcella; Nöthen, Markus M; Falkai, Peter; Heilbronner, Urs; Mueller, Nikola S; Schulze, Thomas G.

In: SCHIZOPHR RES, Vol. 244, 06.2022, p. 29-38.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schulte, EC, Kondofersky, I, Budde, M, Papiol, S, Senner, F, Schaupp, SK, Reich-Erkelenz, D, Klöhn-Saghatolislam, F, Kalman, JL, Gade, K, Hake, M, Comes, AL, Anderson-Schmidt, H, Adorjan, K, Juckel, G, Schmauß, M, Zimmermann, J, Reimer, J, Wiltfang, J, Reininghaus, EZ, Anghelescu, I-G, Konrad, C, Figge, C, von Hagen, M, Jäger, M, Dietrich, DE, Spitzer, C, Witt, SH, Forstner, AJ, Rietschel, M, Nöthen, MM, Falkai, P, Heilbronner, U, Mueller, NS & Schulze, TG 2022, 'A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study', SCHIZOPHR RES, vol. 244, pp. 29-38. https://doi.org/10.1016/j.schres.2022.05.001

APA

Schulte, E. C., Kondofersky, I., Budde, M., Papiol, S., Senner, F., Schaupp, S. K., Reich-Erkelenz, D., Klöhn-Saghatolislam, F., Kalman, J. L., Gade, K., Hake, M., Comes, A. L., Anderson-Schmidt, H., Adorjan, K., Juckel, G., Schmauß, M., Zimmermann, J., Reimer, J., Wiltfang, J., ... Schulze, T. G. (2022). A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study. SCHIZOPHR RES, 244, 29-38. https://doi.org/10.1016/j.schres.2022.05.001

Vancouver

Schulte EC, Kondofersky I, Budde M, Papiol S, Senner F, Schaupp SK et al. A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study. SCHIZOPHR RES. 2022 Jun;244:29-38. https://doi.org/10.1016/j.schres.2022.05.001

Bibtex

@article{b8419ea817ef4fc2a1d7776d85636a35,
title = "A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study",
abstract = "Biological research and clinical management in psychiatry face two major impediments: the high degree of overlap in psychopathology between diagnoses and the inherent heterogeneity with regard to severity. Here, we aim to stratify cases into homogeneous transdiagnostic subgroups using psychometric information with the ultimate aim of identifying individuals with higher risk for severe illness. 397 participants of the PsyCourse study with schizophrenia- or bipolar-spectrum diagnoses were prospectively phenotyped over 18 months. Factor analysis of mixed data of different rating scales and subsequent longitudinal clustering were used to cluster disease trajectories. Five clusters of longitudinal trajectories were identified in the psychopathologic dimensions. Clusters differed significantly with regard to Global Assessment of Functioning, disease course, and-in some cases-diagnosis while there were no significant differences regarding sex, age at baseline or onset, duration of illness, or polygenic burden for schizophrenia. Longitudinal clustering may aid in identifying transdiagnostic homogeneous subgroups of individuals with severe psychiatric disease.",
keywords = "Bipolar Disorder/diagnosis, Cluster Analysis, Hospitals, Humans, Mental Disorders/diagnosis, Psychopathology",
author = "Schulte, {Eva C} and Ivan Kondofersky and Monika Budde and Sergi Papiol and Fanny Senner and Schaupp, {Sabrina K} and Daniela Reich-Erkelenz and Farahnaz Kl{\"o}hn-Saghatolislam and Kalman, {Janos L} and Katrin Gade and Maria Hake and Comes, {Ashley L} and Heike Anderson-Schmidt and Kristina Adorjan and Georg Juckel and Max Schmau{\ss} and J{\"o}rg Zimmermann and Jens Reimer and Jens Wiltfang and Reininghaus, {Eva Z} and Ion-George Anghelescu and Carsten Konrad and Christian Figge and {von Hagen}, Martin and Markus J{\"a}ger and Dietrich, {Detlef E} and Carsten Spitzer and Witt, {Stephanie H} and Forstner, {Andreas J} and Marcella Rietschel and N{\"o}then, {Markus M} and Peter Falkai and Urs Heilbronner and Mueller, {Nikola S} and Schulze, {Thomas G}",
note = "Copyright {\textcopyright} 2022. Published by Elsevier B.V.",
year = "2022",
month = jun,
doi = "10.1016/j.schres.2022.05.001",
language = "English",
volume = "244",
pages = "29--38",
journal = "SCHIZOPHR RES",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A novel longitudinal clustering approach to psychopathology across diagnostic entities in the hospital-based PsyCourse study

AU - Schulte, Eva C

AU - Kondofersky, Ivan

AU - Budde, Monika

AU - Papiol, Sergi

AU - Senner, Fanny

AU - Schaupp, Sabrina K

AU - Reich-Erkelenz, Daniela

AU - Klöhn-Saghatolislam, Farahnaz

AU - Kalman, Janos L

AU - Gade, Katrin

AU - Hake, Maria

AU - Comes, Ashley L

AU - Anderson-Schmidt, Heike

AU - Adorjan, Kristina

AU - Juckel, Georg

AU - Schmauß, Max

AU - Zimmermann, Jörg

AU - Reimer, Jens

AU - Wiltfang, Jens

AU - Reininghaus, Eva Z

AU - Anghelescu, Ion-George

AU - Konrad, Carsten

AU - Figge, Christian

AU - von Hagen, Martin

AU - Jäger, Markus

AU - Dietrich, Detlef E

AU - Spitzer, Carsten

AU - Witt, Stephanie H

AU - Forstner, Andreas J

AU - Rietschel, Marcella

AU - Nöthen, Markus M

AU - Falkai, Peter

AU - Heilbronner, Urs

AU - Mueller, Nikola S

AU - Schulze, Thomas G

N1 - Copyright © 2022. Published by Elsevier B.V.

PY - 2022/6

Y1 - 2022/6

N2 - Biological research and clinical management in psychiatry face two major impediments: the high degree of overlap in psychopathology between diagnoses and the inherent heterogeneity with regard to severity. Here, we aim to stratify cases into homogeneous transdiagnostic subgroups using psychometric information with the ultimate aim of identifying individuals with higher risk for severe illness. 397 participants of the PsyCourse study with schizophrenia- or bipolar-spectrum diagnoses were prospectively phenotyped over 18 months. Factor analysis of mixed data of different rating scales and subsequent longitudinal clustering were used to cluster disease trajectories. Five clusters of longitudinal trajectories were identified in the psychopathologic dimensions. Clusters differed significantly with regard to Global Assessment of Functioning, disease course, and-in some cases-diagnosis while there were no significant differences regarding sex, age at baseline or onset, duration of illness, or polygenic burden for schizophrenia. Longitudinal clustering may aid in identifying transdiagnostic homogeneous subgroups of individuals with severe psychiatric disease.

AB - Biological research and clinical management in psychiatry face two major impediments: the high degree of overlap in psychopathology between diagnoses and the inherent heterogeneity with regard to severity. Here, we aim to stratify cases into homogeneous transdiagnostic subgroups using psychometric information with the ultimate aim of identifying individuals with higher risk for severe illness. 397 participants of the PsyCourse study with schizophrenia- or bipolar-spectrum diagnoses were prospectively phenotyped over 18 months. Factor analysis of mixed data of different rating scales and subsequent longitudinal clustering were used to cluster disease trajectories. Five clusters of longitudinal trajectories were identified in the psychopathologic dimensions. Clusters differed significantly with regard to Global Assessment of Functioning, disease course, and-in some cases-diagnosis while there were no significant differences regarding sex, age at baseline or onset, duration of illness, or polygenic burden for schizophrenia. Longitudinal clustering may aid in identifying transdiagnostic homogeneous subgroups of individuals with severe psychiatric disease.

KW - Bipolar Disorder/diagnosis

KW - Cluster Analysis

KW - Hospitals

KW - Humans

KW - Mental Disorders/diagnosis

KW - Psychopathology

U2 - 10.1016/j.schres.2022.05.001

DO - 10.1016/j.schres.2022.05.001

M3 - SCORING: Journal article

C2 - 35567871

VL - 244

SP - 29

EP - 38

JO - SCHIZOPHR RES

JF - SCHIZOPHR RES

SN - 0920-9964

ER -