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A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma.

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A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma. / Murga-Penas, Eva-Maria; Eva, M; Kawadler, Holli; Siebert, Reiner; Frank, Matthias; Ye, Hongtao; Hinz, Kristina; Becher, Claudia; Hummel, Michael; Barth, Thomas F E; Bokemeyer, Carsten; Stein, Harald; Trümper, Lorenz; Möller, Peter; Marynen, Peter; Du, Ming-Qing; Yang, Xiaolu; Hansmann, Martin L; Dierlamm, Judith.

In: GENE CHROMOSOME CANC, Vol. 45, No. 9, 9, 2006, p. 863-873.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Murga-Penas, E-M, Eva, M, Kawadler, H, Siebert, R, Frank, M, Ye, H, Hinz, K, Becher, C, Hummel, M, Barth, TFE, Bokemeyer, C, Stein, H, Trümper, L, Möller, P, Marynen, P, Du, M-Q, Yang, X, Hansmann, ML & Dierlamm, J 2006, 'A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma.', GENE CHROMOSOME CANC, vol. 45, no. 9, 9, pp. 863-873. <http://www.ncbi.nlm.nih.gov/pubmed/16804917?dopt=Citation>

APA

Murga-Penas, E-M., Eva, M., Kawadler, H., Siebert, R., Frank, M., Ye, H., Hinz, K., Becher, C., Hummel, M., Barth, T. F. E., Bokemeyer, C., Stein, H., Trümper, L., Möller, P., Marynen, P., Du, M-Q., Yang, X., Hansmann, M. L., & Dierlamm, J. (2006). A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma. GENE CHROMOSOME CANC, 45(9), 863-873. [9]. http://www.ncbi.nlm.nih.gov/pubmed/16804917?dopt=Citation

Vancouver

Murga-Penas E-M, Eva M, Kawadler H, Siebert R, Frank M, Ye H et al. A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma. GENE CHROMOSOME CANC. 2006;45(9):863-873. 9.

Bibtex

@article{8c598c679cc844ef8b1ead2a8af02e28,
title = "A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma.",
abstract = "Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3-MALT1 and IGH-MALT1 respectively, and activate the NF-kappaB pathway. Among 122 diffuse large B-cell lymphomas and 28 Burkitt's lymphomas screened by interphase FISH, we found two cases with a break within MALT1, but without a t(11;18) or a t(14;18). Molecular genetic analyses in one of these cases revealed a novel {"}in frame{"} fusion of exon 9 of MALT1 and exon 9 of the microtubule-associated protein 4 (MAP4) gene. The translocation was accompanied by a deletion of MALT1 sequences distal to the breakpoint including the caspase-like domain, which is essential for activation of NF-kappaB. As a result of the deletion, the reciprocal 5'MAP4-3'MALT1 transcript was not present, demonstrating that the 5'MALT1-3'MAP4 fusion represents the pathogenetically relevant transcript. Immunohistochemistry with amino-terminal and carboxy-terminal MALT1 antibodies, indicated a strong expression of the chimeric MALT1-MAP4 protein. Moreover, NF-kappaB activation was not increased in this case as shown by the levels of IkappaBalpha phosphorylation and NEMO ubiquitination. Our data demonstrate that the pathogenetic consequences of the novel MALT1-MAP4 fusion are different from those of the known MALT1-associated chromosomal rearrangements and do not involve NF-kappaB activation.",
author = "Eva-Maria Murga-Penas and M Eva and Holli Kawadler and Reiner Siebert and Matthias Frank and Hongtao Ye and Kristina Hinz and Claudia Becher and Michael Hummel and Barth, {Thomas F E} and Carsten Bokemeyer and Harald Stein and Lorenz Tr{\"u}mper and Peter M{\"o}ller and Peter Marynen and Ming-Qing Du and Xiaolu Yang and Hansmann, {Martin L} and Judith Dierlamm",
year = "2006",
language = "Deutsch",
volume = "45",
pages = "863--873",
journal = "GENE CHROMOSOME CANC",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - A novel fusion of the MALT1 gene and the microtubule-associated protein 4 (MAP4) gene occurs in diffuse large B-cell lymphoma.

AU - Murga-Penas, Eva-Maria

AU - Eva, M

AU - Kawadler, Holli

AU - Siebert, Reiner

AU - Frank, Matthias

AU - Ye, Hongtao

AU - Hinz, Kristina

AU - Becher, Claudia

AU - Hummel, Michael

AU - Barth, Thomas F E

AU - Bokemeyer, Carsten

AU - Stein, Harald

AU - Trümper, Lorenz

AU - Möller, Peter

AU - Marynen, Peter

AU - Du, Ming-Qing

AU - Yang, Xiaolu

AU - Hansmann, Martin L

AU - Dierlamm, Judith

PY - 2006

Y1 - 2006

N2 - Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3-MALT1 and IGH-MALT1 respectively, and activate the NF-kappaB pathway. Among 122 diffuse large B-cell lymphomas and 28 Burkitt's lymphomas screened by interphase FISH, we found two cases with a break within MALT1, but without a t(11;18) or a t(14;18). Molecular genetic analyses in one of these cases revealed a novel "in frame" fusion of exon 9 of MALT1 and exon 9 of the microtubule-associated protein 4 (MAP4) gene. The translocation was accompanied by a deletion of MALT1 sequences distal to the breakpoint including the caspase-like domain, which is essential for activation of NF-kappaB. As a result of the deletion, the reciprocal 5'MAP4-3'MALT1 transcript was not present, demonstrating that the 5'MALT1-3'MAP4 fusion represents the pathogenetically relevant transcript. Immunohistochemistry with amino-terminal and carboxy-terminal MALT1 antibodies, indicated a strong expression of the chimeric MALT1-MAP4 protein. Moreover, NF-kappaB activation was not increased in this case as shown by the levels of IkappaBalpha phosphorylation and NEMO ubiquitination. Our data demonstrate that the pathogenetic consequences of the novel MALT1-MAP4 fusion are different from those of the known MALT1-associated chromosomal rearrangements and do not involve NF-kappaB activation.

AB - Rearrangements of the MALT1 gene by the t(11;18)(q21;q21) and t(14;18)(q32;q21) are the most frequent structural chromosomal abnormalities in MALT lymphomas. These translocations lead to fusions of BIRC3-MALT1 and IGH-MALT1 respectively, and activate the NF-kappaB pathway. Among 122 diffuse large B-cell lymphomas and 28 Burkitt's lymphomas screened by interphase FISH, we found two cases with a break within MALT1, but without a t(11;18) or a t(14;18). Molecular genetic analyses in one of these cases revealed a novel "in frame" fusion of exon 9 of MALT1 and exon 9 of the microtubule-associated protein 4 (MAP4) gene. The translocation was accompanied by a deletion of MALT1 sequences distal to the breakpoint including the caspase-like domain, which is essential for activation of NF-kappaB. As a result of the deletion, the reciprocal 5'MAP4-3'MALT1 transcript was not present, demonstrating that the 5'MALT1-3'MAP4 fusion represents the pathogenetically relevant transcript. Immunohistochemistry with amino-terminal and carboxy-terminal MALT1 antibodies, indicated a strong expression of the chimeric MALT1-MAP4 protein. Moreover, NF-kappaB activation was not increased in this case as shown by the levels of IkappaBalpha phosphorylation and NEMO ubiquitination. Our data demonstrate that the pathogenetic consequences of the novel MALT1-MAP4 fusion are different from those of the known MALT1-associated chromosomal rearrangements and do not involve NF-kappaB activation.

M3 - SCORING: Zeitschriftenaufsatz

VL - 45

SP - 863

EP - 873

JO - GENE CHROMOSOME CANC

JF - GENE CHROMOSOME CANC

SN - 1045-2257

IS - 9

M1 - 9

ER -