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A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels

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A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels. / Sauer, Nina; Rösch, Thomas; Pezold, Jennifer; Reining, Franziska; Anders, Mario; Groth, Stefan; Schachschal, Guido; Mann, Oliver; Aberle, Jens.

In: OBES SURG, Vol. 23, No. 11, 01.11.2013, p. 1727-33.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sauer, N, Rösch, T, Pezold, J, Reining, F, Anders, M, Groth, S, Schachschal, G, Mann, O & Aberle, J 2013, 'A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels', OBES SURG, vol. 23, no. 11, pp. 1727-33. https://doi.org/10.1007/s11695-013-1005-0

APA

Sauer, N., Rösch, T., Pezold, J., Reining, F., Anders, M., Groth, S., Schachschal, G., Mann, O., & Aberle, J. (2013). A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels. OBES SURG, 23(11), 1727-33. https://doi.org/10.1007/s11695-013-1005-0

Vancouver

Sauer N, Rösch T, Pezold J, Reining F, Anders M, Groth S et al. A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels. OBES SURG. 2013 Nov 1;23(11):1727-33. https://doi.org/10.1007/s11695-013-1005-0

Bibtex

@article{65ec24f1a0944c07b4d24f0fdb50c189,
title = "A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels",
abstract = "BACKGROUND: The endoluminal mechanical device SatiSphere is a new endoscopically implantable device designed to delay transit time of nutrients through the duodenum. It consists of a 1-mm nitinol wire with pigtail ends and several mesh spheres mounted along its course, released in the duodenum and gastric antrum to conform to the duodenal C loop configuration and thereby self-anchor.METHODS: The objective is to test the safety, efficacy, and effect on body weight in a 2:1 randomized study, as well as incretin secretion in a subgroup.RESULTS: Of 31 included cases (11 men, mean age 42.9 years, mean BMI 41.3 kg/m2), 21 patients treated with endoscopic device insertion with scheduled device removal after 3 months were compared with 10 controls. In 10 of 21 patients, device migration occurred, in two cases necessitating emergency surgery, which led to termination of the trial. Weight loss after 3 months was 6.7, 4.6, and 2.2 kg in the groups completing therapy, all treatment cases using intention to treat (ITT) analysis and controls. Excess weight loss was significantly increased by endoluminal mechanical device insertion (18.4, 12.2, and 4.4% in completers, ITT analysis group and controls; p = 0.02 for completers vs. controls). Measuring glucose, insulin, and glucagon-like peptide 1 (GLP-1) following a mixed-meal test with the device in place and after removal (n = 7), the device delayed glucose absorption and insulin secretion and altered kinetics in GLP-1 levels.CONCLUSIONS: The device might be short-term effective in reducing body weight, which might be mediated through alterations in incretin metabolism. However, frequent device migration necessitates device modifications.",
author = "Nina Sauer and Thomas R{\"o}sch and Jennifer Pezold and Franziska Reining and Mario Anders and Stefan Groth and Guido Schachschal and Oliver Mann and Jens Aberle",
year = "2013",
month = nov,
day = "1",
doi = "10.1007/s11695-013-1005-0",
language = "English",
volume = "23",
pages = "1727--33",
journal = "OBES SURG",
issn = "0960-8923",
publisher = "Springer New York",
number = "11",

}

RIS

TY - JOUR

T1 - A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels

AU - Sauer, Nina

AU - Rösch, Thomas

AU - Pezold, Jennifer

AU - Reining, Franziska

AU - Anders, Mario

AU - Groth, Stefan

AU - Schachschal, Guido

AU - Mann, Oliver

AU - Aberle, Jens

PY - 2013/11/1

Y1 - 2013/11/1

N2 - BACKGROUND: The endoluminal mechanical device SatiSphere is a new endoscopically implantable device designed to delay transit time of nutrients through the duodenum. It consists of a 1-mm nitinol wire with pigtail ends and several mesh spheres mounted along its course, released in the duodenum and gastric antrum to conform to the duodenal C loop configuration and thereby self-anchor.METHODS: The objective is to test the safety, efficacy, and effect on body weight in a 2:1 randomized study, as well as incretin secretion in a subgroup.RESULTS: Of 31 included cases (11 men, mean age 42.9 years, mean BMI 41.3 kg/m2), 21 patients treated with endoscopic device insertion with scheduled device removal after 3 months were compared with 10 controls. In 10 of 21 patients, device migration occurred, in two cases necessitating emergency surgery, which led to termination of the trial. Weight loss after 3 months was 6.7, 4.6, and 2.2 kg in the groups completing therapy, all treatment cases using intention to treat (ITT) analysis and controls. Excess weight loss was significantly increased by endoluminal mechanical device insertion (18.4, 12.2, and 4.4% in completers, ITT analysis group and controls; p = 0.02 for completers vs. controls). Measuring glucose, insulin, and glucagon-like peptide 1 (GLP-1) following a mixed-meal test with the device in place and after removal (n = 7), the device delayed glucose absorption and insulin secretion and altered kinetics in GLP-1 levels.CONCLUSIONS: The device might be short-term effective in reducing body weight, which might be mediated through alterations in incretin metabolism. However, frequent device migration necessitates device modifications.

AB - BACKGROUND: The endoluminal mechanical device SatiSphere is a new endoscopically implantable device designed to delay transit time of nutrients through the duodenum. It consists of a 1-mm nitinol wire with pigtail ends and several mesh spheres mounted along its course, released in the duodenum and gastric antrum to conform to the duodenal C loop configuration and thereby self-anchor.METHODS: The objective is to test the safety, efficacy, and effect on body weight in a 2:1 randomized study, as well as incretin secretion in a subgroup.RESULTS: Of 31 included cases (11 men, mean age 42.9 years, mean BMI 41.3 kg/m2), 21 patients treated with endoscopic device insertion with scheduled device removal after 3 months were compared with 10 controls. In 10 of 21 patients, device migration occurred, in two cases necessitating emergency surgery, which led to termination of the trial. Weight loss after 3 months was 6.7, 4.6, and 2.2 kg in the groups completing therapy, all treatment cases using intention to treat (ITT) analysis and controls. Excess weight loss was significantly increased by endoluminal mechanical device insertion (18.4, 12.2, and 4.4% in completers, ITT analysis group and controls; p = 0.02 for completers vs. controls). Measuring glucose, insulin, and glucagon-like peptide 1 (GLP-1) following a mixed-meal test with the device in place and after removal (n = 7), the device delayed glucose absorption and insulin secretion and altered kinetics in GLP-1 levels.CONCLUSIONS: The device might be short-term effective in reducing body weight, which might be mediated through alterations in incretin metabolism. However, frequent device migration necessitates device modifications.

U2 - 10.1007/s11695-013-1005-0

DO - 10.1007/s11695-013-1005-0

M3 - SCORING: Journal article

C2 - 23780702

VL - 23

SP - 1727

EP - 1733

JO - OBES SURG

JF - OBES SURG

SN - 0960-8923

IS - 11

ER -