Research ExplorerPublicationsA neurobiological pathway to smoking in adolescence: TTC12-A...

A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response

Standard

A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. / Macare, Christine; Ducci, Francesca; Zhang, Yuning; Ruggeri, Barbara; Jia, Tianye; Kaakinen, Marika; Kalsi, Gursharan; Charoen, Pimphen; Casoni, Filippo; Peters, Jan; Bromberg, Uli; Hill, Matthew; Buxton, Jessica; Blakemore, Alexandra; Veijola, Juha; Büchel, Christian; Banaschewski, Tobias; Bokde, Arun L W; Conrod, Patricia; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny A; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Martinot, Jean-Luc; Paus, Tomáš; Desrivières, Sylvane; Munafò, Marcus; Järvelin, Marjo-Riitta; Schumann, Gunter; IMAGEN Consortium.

In: EUR NEUROPSYCHOPHARM, Vol. 28, No. 10, 10.2018, p. 1103-1114.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Macare, C, Ducci, F, Zhang, Y, Ruggeri, B, Jia, T, Kaakinen, M, Kalsi, G, Charoen, P, Casoni, F, Peters, J, Bromberg, U, Hill, M, Buxton, J, Blakemore, A, Veijola, J, Büchel, C, Banaschewski, T, Bokde, ALW, Conrod, P, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, PA, Heinz, A, Ittermann, B, Lathrop, M, Martinot, J-L, Paus, T, Desrivières, S, Munafò, M, Järvelin, M-R, Schumann, G & IMAGEN Consortium 2018, 'A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response', EUR NEUROPSYCHOPHARM, vol. 28, no. 10, pp. 1103-1114. https://doi.org/10.1016/j.euroneuro.2018.07.101

APA

Macare, C., Ducci, F., Zhang, Y., Ruggeri, B., Jia, T., Kaakinen, M., Kalsi, G., Charoen, P., Casoni, F., Peters, J., Bromberg, U., Hill, M., Buxton, J., Blakemore, A., Veijola, J., Büchel, C., Banaschewski, T., Bokde, A. L. W., Conrod, P., ... IMAGEN Consortium (2018). A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. EUR NEUROPSYCHOPHARM, 28(10), 1103-1114. https://doi.org/10.1016/j.euroneuro.2018.07.101

Vancouver

Macare C, Ducci F, Zhang Y, Ruggeri B, Jia T, Kaakinen M et al. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response. EUR NEUROPSYCHOPHARM. 2018 Oct;28(10):1103-1114. https://doi.org/10.1016/j.euroneuro.2018.07.101

Bibtex

@article{06cf206a5603431f82cc4287025c8f6e,
title = "A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response",
abstract = "The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10-4) and higher plasma cotinine levels (p = 7.0 × 10-5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural",
author = "Christine Macare and Francesca Ducci and Yuning Zhang and Barbara Ruggeri and Tianye Jia and Marika Kaakinen and Gursharan Kalsi and Pimphen Charoen and Filippo Casoni and Jan Peters and Uli Bromberg and Matthew Hill and Jessica Buxton and Alexandra Blakemore and Juha Veijola and Christian B{\"u}chel and Tobias Banaschewski and Bokde, {Arun L W} and Patricia Conrod and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Hugh Garavan and Gowland, {Penny A} and Andreas Heinz and Bernd Ittermann and Mark Lathrop and Jean-Luc Martinot and Tom{\'a}{\v s} Paus and Sylvane Desrivi{\`e}res and Marcus Munaf{\`o} and Marjo-Riitta J{\"a}rvelin and Gunter Schumann and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2018. Published by Elsevier B.V.",
year = "2018",
month = oct,
doi = "10.1016/j.euroneuro.2018.07.101",
language = "English",
volume = "28",
pages = "1103--1114",
journal = "EUR NEUROPSYCHOPHARM",
issn = "0924-977X",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response

AU - Macare, Christine

AU - Ducci, Francesca

AU - Zhang, Yuning

AU - Ruggeri, Barbara

AU - Jia, Tianye

AU - Kaakinen, Marika

AU - Kalsi, Gursharan

AU - Charoen, Pimphen

AU - Casoni, Filippo

AU - Peters, Jan

AU - Bromberg, Uli

AU - Hill, Matthew

AU - Buxton, Jessica

AU - Blakemore, Alexandra

AU - Veijola, Juha

AU - Büchel, Christian

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Conrod, Patricia

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny A

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Lathrop, Mark

AU - Martinot, Jean-Luc

AU - Paus, Tomáš

AU - Desrivières, Sylvane

AU - Munafò, Marcus

AU - Järvelin, Marjo-Riitta

AU - Schumann, Gunter

AU - IMAGEN Consortium

N1 - Copyright © 2018. Published by Elsevier B.V.

PY - 2018/10

Y1 - 2018/10

N2 - The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10-4) and higher plasma cotinine levels (p = 7.0 × 10-5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking.

AB - The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor G-allele of rs2236709, mapping TTC12, was associated with self-reported smoking (p = 5.0 × 10-4) and higher plasma cotinine levels (p = 7.0 × 10-5). This risk allele was linked to an increased ventral-striatal blood-oxygen level-dependent (BOLD) response during reward anticipation (n = 1,263) and with higher DRD2 gene expression in the striatum (p = 0.013), but not with TTC12 or ANKK gene expression. These data suggest a role for the TTC12-ANKK1-DRD2 gene-cluster in adolescent smoking behaviours, provide evidence for the involvement of DRD2 in the early stages of addiction and support the notion that genetically-driven inter-individual differences in dopaminergic transmission mediate reward sensitivity and risk to smoking.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, N.I.H., Extramural

U2 - 10.1016/j.euroneuro.2018.07.101

DO - 10.1016/j.euroneuro.2018.07.101

M3 - SCORING: Journal article

C2 - 30104163

VL - 28

SP - 1103

EP - 1114

JO - EUR NEUROPSYCHOPHARM

JF - EUR NEUROPSYCHOPHARM

SN - 0924-977X

IS - 10

ER -