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A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses

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A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses. / Rades, Dirk; Huttenlocher, Stefan; Veninga, Theo; Bajrovic, Amira; Bremer, Michael; Rudat, Volker; Schild, Steven E.

In: RADIAT ONCOL, Vol. 10, 2015, p. 90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Huttenlocher, S, Veninga, T, Bajrovic, A, Bremer, M, Rudat, V & Schild, SE 2015, 'A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses', RADIAT ONCOL, vol. 10, pp. 90. https://doi.org/10.1186/s13014-015-0403-y

APA

Rades, D., Huttenlocher, S., Veninga, T., Bajrovic, A., Bremer, M., Rudat, V., & Schild, S. E. (2015). A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses. RADIAT ONCOL, 10, 90. https://doi.org/10.1186/s13014-015-0403-y

Vancouver

Rades D, Huttenlocher S, Veninga T, Bajrovic A, Bremer M, Rudat V et al. A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses. RADIAT ONCOL. 2015;10:90. https://doi.org/10.1186/s13014-015-0403-y

Bibtex

@article{27b7e789524c45859b1af2be6c47621c,
title = "A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses",
abstract = "BACKGROUND: It is currently not possible to get an approval of our ethics committee for a randomized trial cmparing 5x4 Gy and 10x3 Gy for MSCC that includes patients with favorable survival prognoses. Therefore, this matched-pair study following strict matching criteria was perfomed instead.METHODS: In this study, 142 receiving 5x4 Gy were retrospectively matched (1:1) to 142 patients receiving 10x3 Gy with respect to ten characteristics. These characteristics included age, gender, performance status, tumor type, involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MSCC, pre-RT ambulatory status, and time developing motor deficits.RESULTS: On multivariate analysis, post-RT motor function was associated with performance status (p<0.001), tumor type (p < 0.001), and time developing motor deficits (p<0.001). RT was successful in 76% of patients receiving 5x4 Gy and 69% receiving 10x3 Gy (p=0.14). Pre.RT ambulatory status showed a strong trend with respect to local control (LC) of MSCC in the multivariate analysis (p=0.058). 1-year LC rates were 87% after 5x4 Gy and 93% after 10x3 Gy (p=0.16). On multivariate analysis, survival (OS) was associated with performance score (p<0.001), visceral metastases (p<0.001), and pre-RT ambulatory status (p=0.004). 1-year OS rates were 68% after 5x4 Gy and 73% after 10x3 Gy (p = 0.64).CONCLUSIONS: In patients irradiated for MSCC who had favorable survival prognoses, post-RT motor function, LC and OS were not significantly different after 5x4 Gy and after 10x3 Gy.",
author = "Dirk Rades and Stefan Huttenlocher and Theo Veninga and Amira Bajrovic and Michael Bremer and Volker Rudat and Schild, {Steven E}",
year = "2015",
doi = "10.1186/s13014-015-0403-y",
language = "English",
volume = "10",
pages = "90",
journal = "RADIAT ONCOL",
issn = "1748-717X",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses

AU - Rades, Dirk

AU - Huttenlocher, Stefan

AU - Veninga, Theo

AU - Bajrovic, Amira

AU - Bremer, Michael

AU - Rudat, Volker

AU - Schild, Steven E

PY - 2015

Y1 - 2015

N2 - BACKGROUND: It is currently not possible to get an approval of our ethics committee for a randomized trial cmparing 5x4 Gy and 10x3 Gy for MSCC that includes patients with favorable survival prognoses. Therefore, this matched-pair study following strict matching criteria was perfomed instead.METHODS: In this study, 142 receiving 5x4 Gy were retrospectively matched (1:1) to 142 patients receiving 10x3 Gy with respect to ten characteristics. These characteristics included age, gender, performance status, tumor type, involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MSCC, pre-RT ambulatory status, and time developing motor deficits.RESULTS: On multivariate analysis, post-RT motor function was associated with performance status (p<0.001), tumor type (p < 0.001), and time developing motor deficits (p<0.001). RT was successful in 76% of patients receiving 5x4 Gy and 69% receiving 10x3 Gy (p=0.14). Pre.RT ambulatory status showed a strong trend with respect to local control (LC) of MSCC in the multivariate analysis (p=0.058). 1-year LC rates were 87% after 5x4 Gy and 93% after 10x3 Gy (p=0.16). On multivariate analysis, survival (OS) was associated with performance score (p<0.001), visceral metastases (p<0.001), and pre-RT ambulatory status (p=0.004). 1-year OS rates were 68% after 5x4 Gy and 73% after 10x3 Gy (p = 0.64).CONCLUSIONS: In patients irradiated for MSCC who had favorable survival prognoses, post-RT motor function, LC and OS were not significantly different after 5x4 Gy and after 10x3 Gy.

AB - BACKGROUND: It is currently not possible to get an approval of our ethics committee for a randomized trial cmparing 5x4 Gy and 10x3 Gy for MSCC that includes patients with favorable survival prognoses. Therefore, this matched-pair study following strict matching criteria was perfomed instead.METHODS: In this study, 142 receiving 5x4 Gy were retrospectively matched (1:1) to 142 patients receiving 10x3 Gy with respect to ten characteristics. These characteristics included age, gender, performance status, tumor type, involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MSCC, pre-RT ambulatory status, and time developing motor deficits.RESULTS: On multivariate analysis, post-RT motor function was associated with performance status (p<0.001), tumor type (p < 0.001), and time developing motor deficits (p<0.001). RT was successful in 76% of patients receiving 5x4 Gy and 69% receiving 10x3 Gy (p=0.14). Pre.RT ambulatory status showed a strong trend with respect to local control (LC) of MSCC in the multivariate analysis (p=0.058). 1-year LC rates were 87% after 5x4 Gy and 93% after 10x3 Gy (p=0.16). On multivariate analysis, survival (OS) was associated with performance score (p<0.001), visceral metastases (p<0.001), and pre-RT ambulatory status (p=0.004). 1-year OS rates were 68% after 5x4 Gy and 73% after 10x3 Gy (p = 0.64).CONCLUSIONS: In patients irradiated for MSCC who had favorable survival prognoses, post-RT motor function, LC and OS were not significantly different after 5x4 Gy and after 10x3 Gy.

U2 - 10.1186/s13014-015-0403-y

DO - 10.1186/s13014-015-0403-y

M3 - SCORING: Journal article

C2 - 25889036

VL - 10

SP - 90

JO - RADIAT ONCOL

JF - RADIAT ONCOL

SN - 1748-717X

ER -