A longitudinal approach to biological psychiatric research. The PsyCourse study

TY - JOUR

T1 - A longitudinal approach to biological psychiatric research. The PsyCourse study

AU - Budde, Monika

AU - Anderson-Schmidt, Heike

AU - Gade, Katrin

AU - Reich-Erkelenz, Daniela

AU - Adorjan, Kristina

AU - Kalman, Janos L

AU - Senner, Fanny

AU - Papiol, Sergi

AU - Andlauer, Till F M

AU - Comes, Ashley L

AU - Schulte, Eva C

AU - Klöhn-Saghatolislam, Farah

AU - Gryaznova, Anna

AU - Hake, Maria

AU - Bartholdi, Kim

AU - Flatau, Laura

AU - Reitt, Markus

AU - Quast, Silke

AU - Stegmaier, Sophia

AU - Meyers, Milena

AU - Emons, Barbara

AU - Haußleiter, Ida Sybille

AU - Juckel, Georg

AU - Nieratschker, Vanessa

AU - Dannlowski, Udo

AU - Schaupp, Sabrina K

AU - Schmauß, Max

AU - Zimmermann, Jörg

AU - Reimer, Jens

AU - Schulz, Sybille

AU - Wiltfang, Jens

AU - Reininghaus, Eva

AU - Anghelescu, Ion-George

AU - Arolt, Volker

AU - Baune, Bernhard T

AU - Konrad, Carsten

AU - Thiel, Andreas

AU - Fallgatter, Andreas J

AU - Figge, Christian

AU - von Hagen, Martin

AU - Koller, Manfred

AU - Lang, Fabian U

AU - Wigand, Moritz E

AU - Becker, Thomas

AU - Jäger, Markus

AU - Dietrich, Detlef E

AU - Stierl, Sebastian

AU - Scherk, Harald

AU - Spitzer, Carsten

AU - Folkerts, Here

AU - Witt, Stephanie H

AU - Degenhardt, Franziska

AU - Forstner, Andreas J

AU - Rietschel, Marcella

AU - Nöthen, Markus M

AU - Falkai, Peter

AU - Schulze, Thomas G

AU - Heilbronner, Urs

N1 - © 2018 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.

PY - 2019/3

Y1 - 2019/3

N2 - In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (N = 891 individuals at baseline), an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) classification system, that is, predominantly affective (n = 367 individuals) versus predominantly psychotic disorders (n = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow-up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.

AB - In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (N = 891 individuals at baseline), an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) classification system, that is, predominantly affective (n = 367 individuals) versus predominantly psychotic disorders (n = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow-up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.

U2 - 10.1002/ajmg.b.32639

DO - 10.1002/ajmg.b.32639

M3 - SCORING: Journal article

C2 - 30070057

VL - 180

SP - 89

EP - 102

JO - AM J MED GENET B

JF - AM J MED GENET B

SN - 1552-4841

IS - 2

ER -