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A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

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A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. / Chen, Ruihuan; Nishimura, Merry C; Bumbaca, Stephanie M; Kharbanda, Samir; Forrest, William F; Kasman, Ian M; Greve, Joan M; Soriano, Robert H; Gilmour, Laurie L; Rivers, Celina Sanchez; Modrusan, Zora; Nacu, Serban; Guerrero, Steve; Edgar, Kyle A; Wallin, Jeffrey J; Lamszus, Katrin; Westphal, Manfred; Heim, Susanne; James, C David; VandenBerg, Scott R; Costello, Joseph F; Moorefield, Scott; Cowdrey, Cynthia J; Prados, Michael; Phillips, Heidi S.

In: CANCER CELL, Vol. 17, No. 4, 4, 2010, p. 362-375.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chen, R, Nishimura, MC, Bumbaca, SM, Kharbanda, S, Forrest, WF, Kasman, IM, Greve, JM, Soriano, RH, Gilmour, LL, Rivers, CS, Modrusan, Z, Nacu, S, Guerrero, S, Edgar, KA, Wallin, JJ, Lamszus, K, Westphal, M, Heim, S, James, CD, VandenBerg, SR, Costello, JF, Moorefield, S, Cowdrey, CJ, Prados, M & Phillips, HS 2010, 'A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.', CANCER CELL, vol. 17, no. 4, 4, pp. 362-375. <http://www.ncbi.nlm.nih.gov/pubmed/20385361?dopt=Citation>

APA

Chen, R., Nishimura, M. C., Bumbaca, S. M., Kharbanda, S., Forrest, W. F., Kasman, I. M., Greve, J. M., Soriano, R. H., Gilmour, L. L., Rivers, C. S., Modrusan, Z., Nacu, S., Guerrero, S., Edgar, K. A., Wallin, J. J., Lamszus, K., Westphal, M., Heim, S., James, C. D., ... Phillips, H. S. (2010). A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. CANCER CELL, 17(4), 362-375. [4]. http://www.ncbi.nlm.nih.gov/pubmed/20385361?dopt=Citation

Vancouver

Chen R, Nishimura MC, Bumbaca SM, Kharbanda S, Forrest WF, Kasman IM et al. A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. CANCER CELL. 2010;17(4):362-375. 4.

Bibtex

@article{3ced7cedeab04f2c81a8d73ae3ea4778,
title = "A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.",
abstract = "The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.",
keywords = "Humans, Immunohistochemistry, Kinetics, Flow Cytometry, Gene Expression Profiling, Cell Differentiation, Antigens, CD analysis, Brain Neoplasms genetics, Cell Division, Cellular Structures pathology, Genetic Linkage, Glioblastoma genetics, Glycoproteins analysis, Neoplastic Stem Cells pathology, Peptides analysis, Humans, Immunohistochemistry, Kinetics, Flow Cytometry, Gene Expression Profiling, Cell Differentiation, Antigens, CD analysis, Brain Neoplasms genetics, Cell Division, Cellular Structures pathology, Genetic Linkage, Glioblastoma genetics, Glycoproteins analysis, Neoplastic Stem Cells pathology, Peptides analysis",
author = "Ruihuan Chen and Nishimura, {Merry C} and Bumbaca, {Stephanie M} and Samir Kharbanda and Forrest, {William F} and Kasman, {Ian M} and Greve, {Joan M} and Soriano, {Robert H} and Gilmour, {Laurie L} and Rivers, {Celina Sanchez} and Zora Modrusan and Serban Nacu and Steve Guerrero and Edgar, {Kyle A} and Wallin, {Jeffrey J} and Katrin Lamszus and Manfred Westphal and Susanne Heim and James, {C David} and VandenBerg, {Scott R} and Costello, {Joseph F} and Scott Moorefield and Cowdrey, {Cynthia J} and Michael Prados and Phillips, {Heidi S}",
year = "2010",
language = "Deutsch",
volume = "17",
pages = "362--375",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.

AU - Chen, Ruihuan

AU - Nishimura, Merry C

AU - Bumbaca, Stephanie M

AU - Kharbanda, Samir

AU - Forrest, William F

AU - Kasman, Ian M

AU - Greve, Joan M

AU - Soriano, Robert H

AU - Gilmour, Laurie L

AU - Rivers, Celina Sanchez

AU - Modrusan, Zora

AU - Nacu, Serban

AU - Guerrero, Steve

AU - Edgar, Kyle A

AU - Wallin, Jeffrey J

AU - Lamszus, Katrin

AU - Westphal, Manfred

AU - Heim, Susanne

AU - James, C David

AU - VandenBerg, Scott R

AU - Costello, Joseph F

AU - Moorefield, Scott

AU - Cowdrey, Cynthia J

AU - Prados, Michael

AU - Phillips, Heidi S

PY - 2010

Y1 - 2010

N2 - The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.

AB - The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.

KW - Humans

KW - Immunohistochemistry

KW - Kinetics

KW - Flow Cytometry

KW - Gene Expression Profiling

KW - Cell Differentiation

KW - Antigens, CD analysis

KW - Brain Neoplasms genetics

KW - Cell Division

KW - Cellular Structures pathology

KW - Genetic Linkage

KW - Glioblastoma genetics

KW - Glycoproteins analysis

KW - Neoplastic Stem Cells pathology

KW - Peptides analysis

KW - Humans

KW - Immunohistochemistry

KW - Kinetics

KW - Flow Cytometry

KW - Gene Expression Profiling

KW - Cell Differentiation

KW - Antigens, CD analysis

KW - Brain Neoplasms genetics

KW - Cell Division

KW - Cellular Structures pathology

KW - Genetic Linkage

KW - Glioblastoma genetics

KW - Glycoproteins analysis

KW - Neoplastic Stem Cells pathology

KW - Peptides analysis

M3 - SCORING: Zeitschriftenaufsatz

VL - 17

SP - 362

EP - 375

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 4

M1 - 4

ER -