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A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study

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A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study. / Luck, T; Riedel-Heller, S G; Luppa, M; Wiese, B; Bachmann, C; Jessen, F; Bickel, H; Weyerer, S; Pentzek, M; König, H-H; Prokein, J; Eisele, M; Wagner, M; Mösch, E; Werle, J; Fuchs, A; Brettschneider, C; Scherer, M; Breitner, J C S; Maier, W.

In: ACTA PSYCHIAT SCAND, Vol. 129, No. 1, 01.01.2014, p. 63-72.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Luck, T, Riedel-Heller, SG, Luppa, M, Wiese, B, Bachmann, C, Jessen, F, Bickel, H, Weyerer, S, Pentzek, M, König, H-H, Prokein, J, Eisele, M, Wagner, M, Mösch, E, Werle, J, Fuchs, A, Brettschneider, C, Scherer, M, Breitner, JCS & Maier, W 2014, 'A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study', ACTA PSYCHIAT SCAND, vol. 129, no. 1, pp. 63-72. https://doi.org/10.1111/acps.12129

APA

Luck, T., Riedel-Heller, S. G., Luppa, M., Wiese, B., Bachmann, C., Jessen, F., Bickel, H., Weyerer, S., Pentzek, M., König, H-H., Prokein, J., Eisele, M., Wagner, M., Mösch, E., Werle, J., Fuchs, A., Brettschneider, C., Scherer, M., Breitner, J. C. S., & Maier, W. (2014). A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study. ACTA PSYCHIAT SCAND, 129(1), 63-72. https://doi.org/10.1111/acps.12129

Vancouver

Luck T, Riedel-Heller SG, Luppa M, Wiese B, Bachmann C, Jessen F et al. A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study. ACTA PSYCHIAT SCAND. 2014 Jan 1;129(1):63-72. https://doi.org/10.1111/acps.12129

Bibtex

@article{a7e97e781cca4b5aa252adee27887177,
title = "A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study",
abstract = "OBJECTIVE: Progression from cognitive impairment (CI) to dementia is predicted by several factors, but their relative importance and interaction are unclear.METHOD: We investigated numerous such factors in the AgeCoDe study, a longitudinal study of general practice patients aged 75+. We used recursive partitioning analysis (RPA) to identify hierarchical patterns of baseline covariates that predicted dementia-free survival.RESULTS: Among 784 non-demented patients with CI, 157 (20.0%) developed dementia over a follow-up interval of 4.5 years. RPA showed that more severe cognitive compromise, revealed by a Mini-Mental State Examination (MMSE) score < 27.47, was the strongest predictor of imminent dementia. Dementia-free survival time was shortest (mean 2.4 years) in such low-scoring patients who also had impaired instrumental activities of daily living (iADL) and subjective memory impairment with related worry (SMI-w). Patients with identical characteristics but without SMI-w had an estimated mean dementia-free survival time of 3.8 years, which was still shorter than in patients who had subthreshold MMSE scores but intact iADL (4.2-5.2 years).CONCLUSION: Hierarchical patterns of readily available covariates can predict dementia-free survival in older general practice patients with CI. Although less widely appreciated than other variables, iADL impairment appears to be an especially noteworthy predictor of progression to dementia.",
author = "T Luck and Riedel-Heller, {S G} and M Luppa and B Wiese and C Bachmann and F Jessen and H Bickel and S Weyerer and M Pentzek and H-H K{\"o}nig and J Prokein and M Eisele and M Wagner and E M{\"o}sch and J Werle and A Fuchs and C Brettschneider and M Scherer and Breitner, {J C S} and W Maier",
note = "{\textcopyright} 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2014",
month = jan,
day = "1",
doi = "10.1111/acps.12129",
language = "English",
volume = "129",
pages = "63--72",
journal = "ACTA PSYCHIAT SCAND",
issn = "0001-690X",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - A hierarchy of predictors for dementia-free survival in old-age: results of the AgeCoDe study

AU - Luck, T

AU - Riedel-Heller, S G

AU - Luppa, M

AU - Wiese, B

AU - Bachmann, C

AU - Jessen, F

AU - Bickel, H

AU - Weyerer, S

AU - Pentzek, M

AU - König, H-H

AU - Prokein, J

AU - Eisele, M

AU - Wagner, M

AU - Mösch, E

AU - Werle, J

AU - Fuchs, A

AU - Brettschneider, C

AU - Scherer, M

AU - Breitner, J C S

AU - Maier, W

N1 - © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - OBJECTIVE: Progression from cognitive impairment (CI) to dementia is predicted by several factors, but their relative importance and interaction are unclear.METHOD: We investigated numerous such factors in the AgeCoDe study, a longitudinal study of general practice patients aged 75+. We used recursive partitioning analysis (RPA) to identify hierarchical patterns of baseline covariates that predicted dementia-free survival.RESULTS: Among 784 non-demented patients with CI, 157 (20.0%) developed dementia over a follow-up interval of 4.5 years. RPA showed that more severe cognitive compromise, revealed by a Mini-Mental State Examination (MMSE) score < 27.47, was the strongest predictor of imminent dementia. Dementia-free survival time was shortest (mean 2.4 years) in such low-scoring patients who also had impaired instrumental activities of daily living (iADL) and subjective memory impairment with related worry (SMI-w). Patients with identical characteristics but without SMI-w had an estimated mean dementia-free survival time of 3.8 years, which was still shorter than in patients who had subthreshold MMSE scores but intact iADL (4.2-5.2 years).CONCLUSION: Hierarchical patterns of readily available covariates can predict dementia-free survival in older general practice patients with CI. Although less widely appreciated than other variables, iADL impairment appears to be an especially noteworthy predictor of progression to dementia.

AB - OBJECTIVE: Progression from cognitive impairment (CI) to dementia is predicted by several factors, but their relative importance and interaction are unclear.METHOD: We investigated numerous such factors in the AgeCoDe study, a longitudinal study of general practice patients aged 75+. We used recursive partitioning analysis (RPA) to identify hierarchical patterns of baseline covariates that predicted dementia-free survival.RESULTS: Among 784 non-demented patients with CI, 157 (20.0%) developed dementia over a follow-up interval of 4.5 years. RPA showed that more severe cognitive compromise, revealed by a Mini-Mental State Examination (MMSE) score < 27.47, was the strongest predictor of imminent dementia. Dementia-free survival time was shortest (mean 2.4 years) in such low-scoring patients who also had impaired instrumental activities of daily living (iADL) and subjective memory impairment with related worry (SMI-w). Patients with identical characteristics but without SMI-w had an estimated mean dementia-free survival time of 3.8 years, which was still shorter than in patients who had subthreshold MMSE scores but intact iADL (4.2-5.2 years).CONCLUSION: Hierarchical patterns of readily available covariates can predict dementia-free survival in older general practice patients with CI. Although less widely appreciated than other variables, iADL impairment appears to be an especially noteworthy predictor of progression to dementia.

U2 - 10.1111/acps.12129

DO - 10.1111/acps.12129

M3 - SCORING: Journal article

C2 - 23521526

VL - 129

SP - 63

EP - 72

JO - ACTA PSYCHIAT SCAND

JF - ACTA PSYCHIAT SCAND

SN - 0001-690X

IS - 1

ER -