A German perspective on the impact of socioeconomic status in diffuse large B-cell lymphoma
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A German perspective on the impact of socioeconomic status in diffuse large B-cell lymphoma. / Ghandili, Susanne; Dierlamm, Judith; Bokemeyer, Carsten; Kusche, Henrik; Peters, Frederik.
In: BLOOD CANCER J, Vol. 14, No. 1, 11.10.2024, p. 174.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - A German perspective on the impact of socioeconomic status in diffuse large B-cell lymphoma
AU - Ghandili, Susanne
AU - Dierlamm, Judith
AU - Bokemeyer, Carsten
AU - Kusche, Henrik
AU - Peters, Frederik
N1 - © 2024. The Author(s).
PY - 2024/10/11
Y1 - 2024/10/11
N2 - The prognostic influence of socioeconomic status (SES) on the survival of diffuse large B-cell lymphoma (DLBCL) patients remains controversial. This observational study examines the potential impact of regional SES inequalities on overall survival (OS) among DLBCL patients in Germany. We analyzed data from the German nationwide population-based dataset spanning 2004-2019 sourced from the German Center for Cancer Registry Data (n = 49,465). The primary objective was to assess the 5-year OS among patients with low SES compared to those living in middle and high SES areas. SES was grouped according to quintiles of the German Index of Socioeconomic Deprivation, which summarized nine indicators covering aspects of regional education, employment, and income. DLBCL patients in low SES areas had significantly impaired 5-year OS compared to those in middle and high SES regions (59.2% vs. 61.8% vs. 64.1%, p < 0.0001). Yet, additionally accounting for regional premature mortality removed the impact of SES on survival (Hazard Ratio 0.94, 95% CI 0.87-1.01). Our findings indicate that the prognostic impact of socioeconomic deprivation on long-term survival is not due to variations in diagnosis and treatment of DLBCL itself but rather a higher comorbidity burden.
AB - The prognostic influence of socioeconomic status (SES) on the survival of diffuse large B-cell lymphoma (DLBCL) patients remains controversial. This observational study examines the potential impact of regional SES inequalities on overall survival (OS) among DLBCL patients in Germany. We analyzed data from the German nationwide population-based dataset spanning 2004-2019 sourced from the German Center for Cancer Registry Data (n = 49,465). The primary objective was to assess the 5-year OS among patients with low SES compared to those living in middle and high SES areas. SES was grouped according to quintiles of the German Index of Socioeconomic Deprivation, which summarized nine indicators covering aspects of regional education, employment, and income. DLBCL patients in low SES areas had significantly impaired 5-year OS compared to those in middle and high SES regions (59.2% vs. 61.8% vs. 64.1%, p < 0.0001). Yet, additionally accounting for regional premature mortality removed the impact of SES on survival (Hazard Ratio 0.94, 95% CI 0.87-1.01). Our findings indicate that the prognostic impact of socioeconomic deprivation on long-term survival is not due to variations in diagnosis and treatment of DLBCL itself but rather a higher comorbidity burden.
KW - Humans
KW - Lymphoma, Large B-Cell, Diffuse/epidemiology
KW - Germany/epidemiology
KW - Male
KW - Female
KW - Middle Aged
KW - Social Class
KW - Aged
KW - Prognosis
KW - Registries
KW - Adult
KW - Aged, 80 and over
KW - Socioeconomic Factors
KW - Survival Rate
U2 - 10.1038/s41408-024-01158-9
DO - 10.1038/s41408-024-01158-9
M3 - SCORING: Journal article
C2 - 39394192
VL - 14
SP - 174
JO - BLOOD CANCER J
JF - BLOOD CANCER J
SN - 2044-5385
IS - 1
ER -
