Research ExplorerPublicationsA genome-wide association study of early gamma-band response...

A genome-wide association study of early gamma-band response in a schizophrenia case-control sample

Standard

A genome-wide association study of early gamma-band response in a schizophrenia case-control sample. / Konte, Bettina; Leicht, Gregor; Giegling, Ina; Pogarell, Oliver; Karch, Susanne; Hartmann, Annette M; Friedl, Marion; Hegerl, Ulrich; Rujescu, Dan; Mulert, Christoph.

In: WORLD J BIOL PSYCHIA, Vol. 19, No. 8, 12.2018, p. 602-609.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Konte, B, Leicht, G, Giegling, I, Pogarell, O, Karch, S, Hartmann, AM, Friedl, M, Hegerl, U, Rujescu, D & Mulert, C 2018, 'A genome-wide association study of early gamma-band response in a schizophrenia case-control sample', WORLD J BIOL PSYCHIA, vol. 19, no. 8, pp. 602-609. https://doi.org/10.1080/15622975.2017.1366054

APA

Konte, B., Leicht, G., Giegling, I., Pogarell, O., Karch, S., Hartmann, A. M., Friedl, M., Hegerl, U., Rujescu, D., & Mulert, C. (2018). A genome-wide association study of early gamma-band response in a schizophrenia case-control sample. WORLD J BIOL PSYCHIA, 19(8), 602-609. https://doi.org/10.1080/15622975.2017.1366054

Vancouver

Konte B, Leicht G, Giegling I, Pogarell O, Karch S, Hartmann AM et al. A genome-wide association study of early gamma-band response in a schizophrenia case-control sample. WORLD J BIOL PSYCHIA. 2018 Dec;19(8):602-609. https://doi.org/10.1080/15622975.2017.1366054

Bibtex

@article{36814cc0327b40d897146aad1bff18cb,
title = "A genome-wide association study of early gamma-band response in a schizophrenia case-control sample",
abstract = "OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity.METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315).RESULTS: No marker surpassed the threshold for genome-wide significant association. Several of the markers that were closest to significance mapped to genes involved in neuronal development and the Neuregulin-ErbB signalling network, such as NRG2 and KALRN. Using a gene-set enrichment analysis, we found suggestive evidence for association with genes involved in EEG abnormality (P = .048).CONCLUSIONS: We identified no marker genome-wide significantly associating with gamma response; independent replication of the gene-set analysis result and larger sample sizes will be required to provide leads to cellular pathways involved in gamma-band activity.",
keywords = "Journal Article",
author = "Bettina Konte and Gregor Leicht and Ina Giegling and Oliver Pogarell and Susanne Karch and Hartmann, {Annette M} and Marion Friedl and Ulrich Hegerl and Dan Rujescu and Christoph Mulert",
year = "2018",
month = dec,
doi = "10.1080/15622975.2017.1366054",
language = "English",
volume = "19",
pages = "602--609",
journal = "WORLD J BIOL PSYCHIA",
issn = "1562-2975",
publisher = "informa healthcare",
number = "8",

}

RIS

TY - JOUR

T1 - A genome-wide association study of early gamma-band response in a schizophrenia case-control sample

AU - Konte, Bettina

AU - Leicht, Gregor

AU - Giegling, Ina

AU - Pogarell, Oliver

AU - Karch, Susanne

AU - Hartmann, Annette M

AU - Friedl, Marion

AU - Hegerl, Ulrich

AU - Rujescu, Dan

AU - Mulert, Christoph

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity.METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315).RESULTS: No marker surpassed the threshold for genome-wide significant association. Several of the markers that were closest to significance mapped to genes involved in neuronal development and the Neuregulin-ErbB signalling network, such as NRG2 and KALRN. Using a gene-set enrichment analysis, we found suggestive evidence for association with genes involved in EEG abnormality (P = .048).CONCLUSIONS: We identified no marker genome-wide significantly associating with gamma response; independent replication of the gene-set analysis result and larger sample sizes will be required to provide leads to cellular pathways involved in gamma-band activity.

AB - OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity.METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315).RESULTS: No marker surpassed the threshold for genome-wide significant association. Several of the markers that were closest to significance mapped to genes involved in neuronal development and the Neuregulin-ErbB signalling network, such as NRG2 and KALRN. Using a gene-set enrichment analysis, we found suggestive evidence for association with genes involved in EEG abnormality (P = .048).CONCLUSIONS: We identified no marker genome-wide significantly associating with gamma response; independent replication of the gene-set analysis result and larger sample sizes will be required to provide leads to cellular pathways involved in gamma-band activity.

KW - Journal Article

U2 - 10.1080/15622975.2017.1366054

DO - 10.1080/15622975.2017.1366054

M3 - SCORING: Journal article

C2 - 28922980

VL - 19

SP - 602

EP - 609

JO - WORLD J BIOL PSYCHIA

JF - WORLD J BIOL PSYCHIA

SN - 1562-2975

IS - 8

ER -