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A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1

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A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. / Morange, Pierre-Emmanuel; Bezemer, Irene; Saut, Noémie; Bare, Lance; Burgos, Gwenaelle; Brocheton, Jessy; Durand, Hervé; Biron-Andreani, Christine; Schved, Jean-Francois; Pernod, Gilles; Galan, Pilar; Drouet, Ludovic; Zelenika, Diana; Germain, Marine; Nicaud, Viviane; Heath, Simon; Ninio, Ewa; Delluc, Aurélien; Münzel, Thomas; Zeller, Tanja; Brand-Herrmann, Stefan-Martin; Alessi, Marie-Christine; Tiret, Laurence; Lathrop, Mark; Cambien, François; Blankenberg, Stefan; Emmerich, Joseph; Trégouët, David-Alexandre; Rosendaal, Frits R.

In: AM J HUM GENET, Vol. 86, No. 4, 09.04.2010, p. 592-595.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morange, P-E, Bezemer, I, Saut, N, Bare, L, Burgos, G, Brocheton, J, Durand, H, Biron-Andreani, C, Schved, J-F, Pernod, G, Galan, P, Drouet, L, Zelenika, D, Germain, M, Nicaud, V, Heath, S, Ninio, E, Delluc, A, Münzel, T, Zeller, T, Brand-Herrmann, S-M, Alessi, M-C, Tiret, L, Lathrop, M, Cambien, F, Blankenberg, S, Emmerich, J, Trégouët, D-A & Rosendaal, FR 2010, 'A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1', AM J HUM GENET, vol. 86, no. 4, pp. 592-595. https://doi.org/10.1016/j.ajhg.2010.02.011

APA

Morange, P-E., Bezemer, I., Saut, N., Bare, L., Burgos, G., Brocheton, J., Durand, H., Biron-Andreani, C., Schved, J-F., Pernod, G., Galan, P., Drouet, L., Zelenika, D., Germain, M., Nicaud, V., Heath, S., Ninio, E., Delluc, A., Münzel, T., ... Rosendaal, F. R. (2010). A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. AM J HUM GENET, 86(4), 592-595. https://doi.org/10.1016/j.ajhg.2010.02.011

Vancouver

Morange P-E, Bezemer I, Saut N, Bare L, Burgos G, Brocheton J et al. A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1. AM J HUM GENET. 2010 Apr 9;86(4):592-595. https://doi.org/10.1016/j.ajhg.2010.02.011

Bibtex

@article{dd417af911564a76851f63050488ed84,
title = "A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1",
abstract = "To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confidence interval 1.13-1.27, p = 2.86 x 10(-9)). HIVEP1 codes for a protein that participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions. The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway.",
keywords = "Case-Control Studies, Chromosomes, Human, Pair 6/genetics, DNA-Binding Proteins/genetics, Follow-Up Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide/genetics, Transcription Factors/genetics, Venous Thrombosis/genetics",
author = "Pierre-Emmanuel Morange and Irene Bezemer and No{\'e}mie Saut and Lance Bare and Gwenaelle Burgos and Jessy Brocheton and Herv{\'e} Durand and Christine Biron-Andreani and Jean-Francois Schved and Gilles Pernod and Pilar Galan and Ludovic Drouet and Diana Zelenika and Marine Germain and Viviane Nicaud and Simon Heath and Ewa Ninio and Aur{\'e}lien Delluc and Thomas M{\"u}nzel and Tanja Zeller and Stefan-Martin Brand-Herrmann and Marie-Christine Alessi and Laurence Tiret and Mark Lathrop and Fran{\c c}ois Cambien and Stefan Blankenberg and Joseph Emmerich and David-Alexandre Tr{\'e}gou{\"e}t and Rosendaal, {Frits R}",
note = "(c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.",
year = "2010",
month = apr,
day = "9",
doi = "10.1016/j.ajhg.2010.02.011",
language = "English",
volume = "86",
pages = "592--595",
journal = "AM J HUM GENET",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1

AU - Morange, Pierre-Emmanuel

AU - Bezemer, Irene

AU - Saut, Noémie

AU - Bare, Lance

AU - Burgos, Gwenaelle

AU - Brocheton, Jessy

AU - Durand, Hervé

AU - Biron-Andreani, Christine

AU - Schved, Jean-Francois

AU - Pernod, Gilles

AU - Galan, Pilar

AU - Drouet, Ludovic

AU - Zelenika, Diana

AU - Germain, Marine

AU - Nicaud, Viviane

AU - Heath, Simon

AU - Ninio, Ewa

AU - Delluc, Aurélien

AU - Münzel, Thomas

AU - Zeller, Tanja

AU - Brand-Herrmann, Stefan-Martin

AU - Alessi, Marie-Christine

AU - Tiret, Laurence

AU - Lathrop, Mark

AU - Cambien, François

AU - Blankenberg, Stefan

AU - Emmerich, Joseph

AU - Trégouët, David-Alexandre

AU - Rosendaal, Frits R

N1 - (c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

PY - 2010/4/9

Y1 - 2010/4/9

N2 - To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confidence interval 1.13-1.27, p = 2.86 x 10(-9)). HIVEP1 codes for a protein that participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions. The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway.

AB - To identify genetic susceptibility factors conferring increased risk of venous thrombosis (VT), we conducted a multistage study, following results of a previously published GWAS that failed to detect loci for developing VT. Using a collection of 5862 cases with VT and 7112 healthy controls, we identified the HIVEP1 locus on chromosome 6p24.1 as a susceptibility locus for VT. Indeed, the HIVEP1 rs169713C allele was associated with an increased risk for VT, with an odds ratio of 1.20 (95% confidence interval 1.13-1.27, p = 2.86 x 10(-9)). HIVEP1 codes for a protein that participates in the transcriptional regulation of inflammatory target genes by binding specific DNA sequences in their promoter and enhancer regions. The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway.

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 6/genetics

KW - DNA-Binding Proteins/genetics

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Polymorphism, Single Nucleotide/genetics

KW - Transcription Factors/genetics

KW - Venous Thrombosis/genetics

U2 - 10.1016/j.ajhg.2010.02.011

DO - 10.1016/j.ajhg.2010.02.011

M3 - SCORING: Journal article

C2 - 20226436

VL - 86

SP - 592

EP - 595

JO - AM J HUM GENET

JF - AM J HUM GENET

SN - 0002-9297

IS - 4

ER -