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A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS

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A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. / Maccari, Maria Elena; Fuchs, Sebastian; Kury, Patrick; Andrieux, Geoffroy; Völkl, Simon; Bengsch, Bertram; Lorenz, Myriam Ricarda; Heeg, Maximilian; Rohr, Jan; Jägle, Sabine; Castro, Carla N; Groß, Miriam; Warthorst, Ursula; König, Christoph; Fuchs, Ilka; Speckmann, Carsten; Thalhammer, Julian; Kapp, Friedrich G; Seidel, Markus G; Dückers, Gregor; Schönberger, Stefan; Schütz, Catharina; Führer, Marita; Kobbe, Robin; Holzinger, Dirk; Klemann, Christian; Smisek, Petr; Owens, Stephen; Horneff, Gerd; Kolb, Reinhard; Naumann-Bartsch, Nora; Miano, Maurizio; Staniek, Julian; Rizzi, Marta; Kalina, Tomas; Schneider, Pascal; Erxleben, Anika; Backofen, Rolf; Ekici, Arif; Niemeyer, Charlotte M; Warnatz, Klaus; Grimbacher, Bodo; Eibel, Hermann; Mackensen, Andreas; Frei, Andreas Philipp; Schwarz, Klaus; Boerries, Melanie; Ehl, Stephan; Rensing-Ehl, Anne.

In: J EXP MED, Vol. 218, No. 2, 01.02.2021, p. e20192191.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Maccari, ME, Fuchs, S, Kury, P, Andrieux, G, Völkl, S, Bengsch, B, Lorenz, MR, Heeg, M, Rohr, J, Jägle, S, Castro, CN, Groß, M, Warthorst, U, König, C, Fuchs, I, Speckmann, C, Thalhammer, J, Kapp, FG, Seidel, MG, Dückers, G, Schönberger, S, Schütz, C, Führer, M, Kobbe, R, Holzinger, D, Klemann, C, Smisek, P, Owens, S, Horneff, G, Kolb, R, Naumann-Bartsch, N, Miano, M, Staniek, J, Rizzi, M, Kalina, T, Schneider, P, Erxleben, A, Backofen, R, Ekici, A, Niemeyer, CM, Warnatz, K, Grimbacher, B, Eibel, H, Mackensen, A, Frei, AP, Schwarz, K, Boerries, M, Ehl, S & Rensing-Ehl, A 2021, 'A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS', J EXP MED, vol. 218, no. 2, pp. e20192191. https://doi.org/10.1084/jem.20192191

APA

Maccari, M. E., Fuchs, S., Kury, P., Andrieux, G., Völkl, S., Bengsch, B., Lorenz, M. R., Heeg, M., Rohr, J., Jägle, S., Castro, C. N., Groß, M., Warthorst, U., König, C., Fuchs, I., Speckmann, C., Thalhammer, J., Kapp, F. G., Seidel, M. G., ... Rensing-Ehl, A. (2021). A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. J EXP MED, 218(2), e20192191. https://doi.org/10.1084/jem.20192191

Vancouver

Maccari ME, Fuchs S, Kury P, Andrieux G, Völkl S, Bengsch B et al. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. J EXP MED. 2021 Feb 1;218(2):e20192191. https://doi.org/10.1084/jem.20192191

Bibtex

@article{0ca3b46d74a9414d901cda90e2371ce4,
title = "A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS",
abstract = "The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.",
author = "Maccari, {Maria Elena} and Sebastian Fuchs and Patrick Kury and Geoffroy Andrieux and Simon V{\"o}lkl and Bertram Bengsch and Lorenz, {Myriam Ricarda} and Maximilian Heeg and Jan Rohr and Sabine J{\"a}gle and Castro, {Carla N} and Miriam Gro{\ss} and Ursula Warthorst and Christoph K{\"o}nig and Ilka Fuchs and Carsten Speckmann and Julian Thalhammer and Kapp, {Friedrich G} and Seidel, {Markus G} and Gregor D{\"u}ckers and Stefan Sch{\"o}nberger and Catharina Sch{\"u}tz and Marita F{\"u}hrer and Robin Kobbe and Dirk Holzinger and Christian Klemann and Petr Smisek and Stephen Owens and Gerd Horneff and Reinhard Kolb and Nora Naumann-Bartsch and Maurizio Miano and Julian Staniek and Marta Rizzi and Tomas Kalina and Pascal Schneider and Anika Erxleben and Rolf Backofen and Arif Ekici and Niemeyer, {Charlotte M} and Klaus Warnatz and Bodo Grimbacher and Hermann Eibel and Andreas Mackensen and Frei, {Andreas Philipp} and Klaus Schwarz and Melanie Boerries and Stephan Ehl and Anne Rensing-Ehl",
note = "{\textcopyright} 2020 Maccari et al.",
year = "2021",
month = feb,
day = "1",
doi = "10.1084/jem.20192191",
language = "English",
volume = "218",
pages = "e20192191",
journal = "J EXP MED",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "2",

}

RIS

TY - JOUR

T1 - A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS

AU - Maccari, Maria Elena

AU - Fuchs, Sebastian

AU - Kury, Patrick

AU - Andrieux, Geoffroy

AU - Völkl, Simon

AU - Bengsch, Bertram

AU - Lorenz, Myriam Ricarda

AU - Heeg, Maximilian

AU - Rohr, Jan

AU - Jägle, Sabine

AU - Castro, Carla N

AU - Groß, Miriam

AU - Warthorst, Ursula

AU - König, Christoph

AU - Fuchs, Ilka

AU - Speckmann, Carsten

AU - Thalhammer, Julian

AU - Kapp, Friedrich G

AU - Seidel, Markus G

AU - Dückers, Gregor

AU - Schönberger, Stefan

AU - Schütz, Catharina

AU - Führer, Marita

AU - Kobbe, Robin

AU - Holzinger, Dirk

AU - Klemann, Christian

AU - Smisek, Petr

AU - Owens, Stephen

AU - Horneff, Gerd

AU - Kolb, Reinhard

AU - Naumann-Bartsch, Nora

AU - Miano, Maurizio

AU - Staniek, Julian

AU - Rizzi, Marta

AU - Kalina, Tomas

AU - Schneider, Pascal

AU - Erxleben, Anika

AU - Backofen, Rolf

AU - Ekici, Arif

AU - Niemeyer, Charlotte M

AU - Warnatz, Klaus

AU - Grimbacher, Bodo

AU - Eibel, Hermann

AU - Mackensen, Andreas

AU - Frei, Andreas Philipp

AU - Schwarz, Klaus

AU - Boerries, Melanie

AU - Ehl, Stephan

AU - Rensing-Ehl, Anne

N1 - © 2020 Maccari et al.

PY - 2021/2/1

Y1 - 2021/2/1

N2 - The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.

AB - The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune lymphoproliferative syndrome to identify a population of FAS-controlled TCRαβ+ T cells. They include CD4+, CD8+, and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in healthy individuals, are generated before birth, are enriched in lymphoid tissue, and do not expand during acute viral infection. They are characterized by a unique molecular signature that is unambiguously different from other known T cell differentiation subsets and independent of CD4 or CD8 expression. Functionally, FAS-controlled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias. Mechanistically, regulation of this physiological population is mediated by FAS and CTLA4 signaling, and its survival is enhanced by mTOR and STAT3 signals. Genetic alterations in these pathways result in expansion of FAS-controlled T cells, which can cause significant lymphoproliferative disease.

U2 - 10.1084/jem.20192191

DO - 10.1084/jem.20192191

M3 - SCORING: Journal article

C2 - 33170215

VL - 218

SP - e20192191

JO - J EXP MED

JF - J EXP MED

SN - 0022-1007

IS - 2

ER -