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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. / Nikpay, Majid; Goel, Anuj; Won, Hong-Hee; Hall, Leanne M; Willenborg, Christina; Kanoni, Stavroula; Saleheen, Danish; Kyriakou, Theodosios; Nelson, Christopher P; Hopewell, Jemma C; Webb, Thomas R; Zeng, Lingyao; Dehghan, Abbas; Alver, Maris; Armasu, Sebastian M; Auro, Kirsi; Bjonnes, Andrew; Chasman, Daniel I; Chen, Shufeng; Ford, Ian; Franceschini, Nora; Gieger, Christian; Grace, Christopher; Gustafsson, Stefan; Huang, Jie; Hwang, Shih-Jen; Kim, Yun Kyoung; Kleber, Marcus E; Lau, King Wai; Lu, Xiangfeng; Lu, Yingchang; Lyytikäinen, Leo-Pekka; Mihailov, Evelin; Morrison, Alanna C; Pervjakova, Natalia; Qu, Liming; Rose, Lynda M; Salfati, Elias; Saxena, Richa; Scholz, Markus; Smith, Albert V; Tikkanen, Emmi; Uitterlinden, Andre; Yang, Xueli; Zhang, Weihua; Zhao, Wei; de Andrade, Mariza; de Vries, Paul S; van Zuydam, Natalie R; Anand, Sonia S; Bertram, Lars; Beutner, Frank; Dedoussis, George; Frossard, Philippe; Gauguier, Dominique; Goodall, Alison H; Gottesman, Omri; Haber, Marc; Han, Bok-Ghee; Huang, Jianfeng; Jalilzadeh, Shapour; Kessler, Thorsten; König, Inke R; Lannfelt, Lars; Lieb, Wolfgang; Lind, Lars; Lindgren, Cecilia M; Lokki, Marja-Liisa; Magnusson, Patrik K; Mallick, Nadeem H; Mehra, Narinder; Meitinger, Thomas; Memon, Fazal-ur-Rehman; Morris, Andrew P; Nieminen, Markku S; Pedersen, Nancy L; Peters, Annette; Rallidis, Loukianos S; Rasheed, Asif; Samuel, Maria; Shah, Svati H; Sinisalo, Juha; Stirrups, Kathleen E; Trompet, Stella; Wang, Laiyuan; Zaman, Khan S; Ardissino, Diego; Boerwinkle, Eric; Borecki, Ingrid B; Bottinger, Erwin P; Buring, Julie E; Chambers, John C; Collins, Rory; Cupples, L Adrienne; Danesh, John; Demuth, Ilja; Elosua, Roberto; Epstein, Stephen E; Esko, Tõnu; Feitosa, Mary F; Franco, Oscar H; Franzosi, Maria Grazia; Granger, Christopher B; Gu, Dongfeng; Gudnason, Vilmundur; Hall, Alistair S; Hamsten, Anders; Harris, Tamara B; Hazen, Stanley L; Hengstenberg, Christian; Hofman, Albert; Ingelsson, Erik; Iribarren, Carlos; Jukema, J Wouter; Karhunen, Pekka J; Kim, Bong-Jo; Kooner, Jaspal S; Kullo, Iftikhar J; Lehtimäki, Terho; Loos, Ruth J F; Melander, Olle; Metspalu, Andres; März, Winfried; Palmer, Colin N; Perola, Markus; Quertermous, Thomas; Rader, Daniel J; Ridker, Paul M; Ripatti, Samuli; Roberts, Robert; Salomaa, Veikko; Sanghera, Dharambir K; Schwartz, Stephen M; Seedorf, Udo; Stewart, Alexandre F; Stott, David J; Thiery, Joachim; Zalloua, Pierre A; O'Donnell, Christopher J; Reilly, Muredach P; Assimes, Themistocles L; Thompson, John R; Erdmann, Jeanette; Clarke, Robert; Watkins, Hugh; Kathiresan, Sekar; McPherson, Ruth; Deloukas, Panos; Schunkert, Heribert; Samani, Nilesh J; Farrall, Martin; CARDIoGRAMplusC4D Consortium.

In: NAT GENET, Vol. 47, No. 10, 10.2015, p. 1121-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nikpay, M, Goel, A, Won, H-H, Hall, LM, Willenborg, C, Kanoni, S, Saleheen, D, Kyriakou, T, Nelson, CP, Hopewell, JC, Webb, TR, Zeng, L, Dehghan, A, Alver, M, Armasu, SM, Auro, K, Bjonnes, A, Chasman, DI, Chen, S, Ford, I, Franceschini, N, Gieger, C, Grace, C, Gustafsson, S, Huang, J, Hwang, S-J, Kim, YK, Kleber, ME, Lau, KW, Lu, X, Lu, Y, Lyytikäinen, L-P, Mihailov, E, Morrison, AC, Pervjakova, N, Qu, L, Rose, LM, Salfati, E, Saxena, R, Scholz, M, Smith, AV, Tikkanen, E, Uitterlinden, A, Yang, X, Zhang, W, Zhao, W, de Andrade, M, de Vries, PS, van Zuydam, NR, Anand, SS, Bertram, L, Beutner, F, Dedoussis, G, Frossard, P, Gauguier, D, Goodall, AH, Gottesman, O, Haber, M, Han, B-G, Huang, J, Jalilzadeh, S, Kessler, T, König, IR, Lannfelt, L, Lieb, W, Lind, L, Lindgren, CM, Lokki, M-L, Magnusson, PK, Mallick, NH, Mehra, N, Meitinger, T, Memon, F-R, Morris, AP, Nieminen, MS, Pedersen, NL, Peters, A, Rallidis, LS, Rasheed, A, Samuel, M, Shah, SH, Sinisalo, J, Stirrups, KE, Trompet, S, Wang, L, Zaman, KS, Ardissino, D, Boerwinkle, E, Borecki, IB, Bottinger, EP, Buring, JE, Chambers, JC, Collins, R, Cupples, LA, Danesh, J, Demuth, I, Elosua, R, Epstein, SE, Esko, T, Feitosa, MF, Franco, OH, Franzosi, MG, Granger, CB, Gu, D, Gudnason, V, Hall, AS, Hamsten, A, Harris, TB, Hazen, SL, Hengstenberg, C, Hofman, A, Ingelsson, E, Iribarren, C, Jukema, JW, Karhunen, PJ, Kim, B-J, Kooner, JS, Kullo, IJ, Lehtimäki, T, Loos, RJF, Melander, O, Metspalu, A, März, W, Palmer, CN, Perola, M, Quertermous, T, Rader, DJ, Ridker, PM, Ripatti, S, Roberts, R, Salomaa, V, Sanghera, DK, Schwartz, SM, Seedorf, U, Stewart, AF, Stott, DJ, Thiery, J, Zalloua, PA, O'Donnell, CJ, Reilly, MP, Assimes, TL, Thompson, JR, Erdmann, J, Clarke, R, Watkins, H, Kathiresan, S, McPherson, R, Deloukas, P, Schunkert, H, Samani, NJ, Farrall, M & CARDIoGRAMplusC4D Consortium 2015, 'A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease', NAT GENET, vol. 47, no. 10, pp. 1121-30. https://doi.org/10.1038/ng.3396

APA

Nikpay, M., Goel, A., Won, H-H., Hall, L. M., Willenborg, C., Kanoni, S., Saleheen, D., Kyriakou, T., Nelson, C. P., Hopewell, J. C., Webb, T. R., Zeng, L., Dehghan, A., Alver, M., Armasu, S. M., Auro, K., Bjonnes, A., Chasman, D. I., Chen, S., ... CARDIoGRAMplusC4D Consortium (2015). A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. NAT GENET, 47(10), 1121-30. https://doi.org/10.1038/ng.3396

Vancouver

Nikpay M, Goel A, Won H-H, Hall LM, Willenborg C, Kanoni S et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. NAT GENET. 2015 Oct;47(10):1121-30. https://doi.org/10.1038/ng.3396

Bibtex

@article{0aae47595d914485a4c423d1546e9acd,
title = "A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease",
abstract = "Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.",
keywords = "Coronary Artery Disease, Genome, Human, Genome-Wide Association Study, Humans, Phenotype",
author = "Majid Nikpay and Anuj Goel and Hong-Hee Won and Hall, {Leanne M} and Christina Willenborg and Stavroula Kanoni and Danish Saleheen and Theodosios Kyriakou and Nelson, {Christopher P} and Hopewell, {Jemma C} and Webb, {Thomas R} and Lingyao Zeng and Abbas Dehghan and Maris Alver and Armasu, {Sebastian M} and Kirsi Auro and Andrew Bjonnes and Chasman, {Daniel I} and Shufeng Chen and Ian Ford and Nora Franceschini and Christian Gieger and Christopher Grace and Stefan Gustafsson and Jie Huang and Shih-Jen Hwang and Kim, {Yun Kyoung} and Kleber, {Marcus E} and Lau, {King Wai} and Xiangfeng Lu and Yingchang Lu and Leo-Pekka Lyytik{\"a}inen and Evelin Mihailov and Morrison, {Alanna C} and Natalia Pervjakova and Liming Qu and Rose, {Lynda M} and Elias Salfati and Richa Saxena and Markus Scholz and Smith, {Albert V} and Emmi Tikkanen and Andre Uitterlinden and Xueli Yang and Weihua Zhang and Wei Zhao and {de Andrade}, Mariza and {de Vries}, {Paul S} and {van Zuydam}, {Natalie R} and Anand, {Sonia S} and Lars Bertram and Frank Beutner and George Dedoussis and Philippe Frossard and Dominique Gauguier and Goodall, {Alison H} and Omri Gottesman and Marc Haber and Bok-Ghee Han and Jianfeng Huang and Shapour Jalilzadeh and Thorsten Kessler and K{\"o}nig, {Inke R} and Lars Lannfelt and Wolfgang Lieb and Lars Lind and Lindgren, {Cecilia M} and Marja-Liisa Lokki and Magnusson, {Patrik K} and Mallick, {Nadeem H} and Narinder Mehra and Thomas Meitinger and Fazal-ur-Rehman Memon and Morris, {Andrew P} and Nieminen, {Markku S} and Pedersen, {Nancy L} and Annette Peters and Rallidis, {Loukianos S} and Asif Rasheed and Maria Samuel and Shah, {Svati H} and Juha Sinisalo and Stirrups, {Kathleen E} and Stella Trompet and Laiyuan Wang and Zaman, {Khan S} and Diego Ardissino and Eric Boerwinkle and Borecki, {Ingrid B} and Bottinger, {Erwin P} and Buring, {Julie E} and Chambers, {John C} and Rory Collins and Cupples, {L Adrienne} and John Danesh and Ilja Demuth and Roberto Elosua and Epstein, {Stephen E} and T{\~o}nu Esko and Feitosa, {Mary F} and Franco, {Oscar H} and Franzosi, {Maria Grazia} and Granger, {Christopher B} and Dongfeng Gu and Vilmundur Gudnason and Hall, {Alistair S} and Anders Hamsten and Harris, {Tamara B} and Hazen, {Stanley L} and Christian Hengstenberg and Albert Hofman and Erik Ingelsson and Carlos Iribarren and Jukema, {J Wouter} and Karhunen, {Pekka J} and Bong-Jo Kim and Kooner, {Jaspal S} and Kullo, {Iftikhar J} and Terho Lehtim{\"a}ki and Loos, {Ruth J F} and Olle Melander and Andres Metspalu and Winfried M{\"a}rz and Palmer, {Colin N} and Markus Perola and Thomas Quertermous and Rader, {Daniel J} and Ridker, {Paul M} and Samuli Ripatti and Robert Roberts and Veikko Salomaa and Sanghera, {Dharambir K} and Schwartz, {Stephen M} and Udo Seedorf and Stewart, {Alexandre F} and Stott, {David J} and Joachim Thiery and Zalloua, {Pierre A} and O'Donnell, {Christopher J} and Reilly, {Muredach P} and Assimes, {Themistocles L} and Thompson, {John R} and Jeanette Erdmann and Robert Clarke and Hugh Watkins and Sekar Kathiresan and Ruth McPherson and Panos Deloukas and Heribert Schunkert and Samani, {Nilesh J} and Martin Farrall and {CARDIoGRAMplusC4D Consortium}",
year = "2015",
month = oct,
doi = "10.1038/ng.3396",
language = "English",
volume = "47",
pages = "1121--30",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

AU - Nikpay, Majid

AU - Goel, Anuj

AU - Won, Hong-Hee

AU - Hall, Leanne M

AU - Willenborg, Christina

AU - Kanoni, Stavroula

AU - Saleheen, Danish

AU - Kyriakou, Theodosios

AU - Nelson, Christopher P

AU - Hopewell, Jemma C

AU - Webb, Thomas R

AU - Zeng, Lingyao

AU - Dehghan, Abbas

AU - Alver, Maris

AU - Armasu, Sebastian M

AU - Auro, Kirsi

AU - Bjonnes, Andrew

AU - Chasman, Daniel I

AU - Chen, Shufeng

AU - Ford, Ian

AU - Franceschini, Nora

AU - Gieger, Christian

AU - Grace, Christopher

AU - Gustafsson, Stefan

AU - Huang, Jie

AU - Hwang, Shih-Jen

AU - Kim, Yun Kyoung

AU - Kleber, Marcus E

AU - Lau, King Wai

AU - Lu, Xiangfeng

AU - Lu, Yingchang

AU - Lyytikäinen, Leo-Pekka

AU - Mihailov, Evelin

AU - Morrison, Alanna C

AU - Pervjakova, Natalia

AU - Qu, Liming

AU - Rose, Lynda M

AU - Salfati, Elias

AU - Saxena, Richa

AU - Scholz, Markus

AU - Smith, Albert V

AU - Tikkanen, Emmi

AU - Uitterlinden, Andre

AU - Yang, Xueli

AU - Zhang, Weihua

AU - Zhao, Wei

AU - de Andrade, Mariza

AU - de Vries, Paul S

AU - van Zuydam, Natalie R

AU - Anand, Sonia S

AU - Bertram, Lars

AU - Beutner, Frank

AU - Dedoussis, George

AU - Frossard, Philippe

AU - Gauguier, Dominique

AU - Goodall, Alison H

AU - Gottesman, Omri

AU - Haber, Marc

AU - Han, Bok-Ghee

AU - Huang, Jianfeng

AU - Jalilzadeh, Shapour

AU - Kessler, Thorsten

AU - König, Inke R

AU - Lannfelt, Lars

AU - Lieb, Wolfgang

AU - Lind, Lars

AU - Lindgren, Cecilia M

AU - Lokki, Marja-Liisa

AU - Magnusson, Patrik K

AU - Mallick, Nadeem H

AU - Mehra, Narinder

AU - Meitinger, Thomas

AU - Memon, Fazal-ur-Rehman

AU - Morris, Andrew P

AU - Nieminen, Markku S

AU - Pedersen, Nancy L

AU - Peters, Annette

AU - Rallidis, Loukianos S

AU - Rasheed, Asif

AU - Samuel, Maria

AU - Shah, Svati H

AU - Sinisalo, Juha

AU - Stirrups, Kathleen E

AU - Trompet, Stella

AU - Wang, Laiyuan

AU - Zaman, Khan S

AU - Ardissino, Diego

AU - Boerwinkle, Eric

AU - Borecki, Ingrid B

AU - Bottinger, Erwin P

AU - Buring, Julie E

AU - Chambers, John C

AU - Collins, Rory

AU - Cupples, L Adrienne

AU - Danesh, John

AU - Demuth, Ilja

AU - Elosua, Roberto

AU - Epstein, Stephen E

AU - Esko, Tõnu

AU - Feitosa, Mary F

AU - Franco, Oscar H

AU - Franzosi, Maria Grazia

AU - Granger, Christopher B

AU - Gu, Dongfeng

AU - Gudnason, Vilmundur

AU - Hall, Alistair S

AU - Hamsten, Anders

AU - Harris, Tamara B

AU - Hazen, Stanley L

AU - Hengstenberg, Christian

AU - Hofman, Albert

AU - Ingelsson, Erik

AU - Iribarren, Carlos

AU - Jukema, J Wouter

AU - Karhunen, Pekka J

AU - Kim, Bong-Jo

AU - Kooner, Jaspal S

AU - Kullo, Iftikhar J

AU - Lehtimäki, Terho

AU - Loos, Ruth J F

AU - Melander, Olle

AU - Metspalu, Andres

AU - März, Winfried

AU - Palmer, Colin N

AU - Perola, Markus

AU - Quertermous, Thomas

AU - Rader, Daniel J

AU - Ridker, Paul M

AU - Ripatti, Samuli

AU - Roberts, Robert

AU - Salomaa, Veikko

AU - Sanghera, Dharambir K

AU - Schwartz, Stephen M

AU - Seedorf, Udo

AU - Stewart, Alexandre F

AU - Stott, David J

AU - Thiery, Joachim

AU - Zalloua, Pierre A

AU - O'Donnell, Christopher J

AU - Reilly, Muredach P

AU - Assimes, Themistocles L

AU - Thompson, John R

AU - Erdmann, Jeanette

AU - Clarke, Robert

AU - Watkins, Hugh

AU - Kathiresan, Sekar

AU - McPherson, Ruth

AU - Deloukas, Panos

AU - Schunkert, Heribert

AU - Samani, Nilesh J

AU - Farrall, Martin

AU - CARDIoGRAMplusC4D Consortium

PY - 2015/10

Y1 - 2015/10

N2 - Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.

AB - Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. Our analysis provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.

KW - Coronary Artery Disease

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Humans

KW - Phenotype

U2 - 10.1038/ng.3396

DO - 10.1038/ng.3396

M3 - SCORING: Journal article

C2 - 26343387

VL - 47

SP - 1121

EP - 1130

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 10

ER -