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A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD

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A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD. / Ziegler, Georg C. ; Ehlis, Ann-Christine; Weber, Heike; Vitale, Maria Rosaria; Zöller, Johanne E. M. ; Ku, Hsing-Ping; Schiele, Miriam A.; Kürbitz, Laura; Romanos, Marcel; Pauli, Paul; Kalisch, Raffael; Zwanzger, Peter; Domschke, Katharina; Fallgatter, Andreas J.; Reif, Andreas; Lesch, Klaus-Peter.

In: GENES-BASEL, Vol. 12, No. 9, 1356, 29.08.2021, p. 1-14.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ziegler, GC, Ehlis, A-C, Weber, H, Vitale, MR, Zöller, JEM, Ku, H-P, Schiele, MA, Kürbitz, L, Romanos, M, Pauli, P, Kalisch, R, Zwanzger, P, Domschke, K, Fallgatter, AJ, Reif, A & Lesch, K-P 2021, 'A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD', GENES-BASEL, vol. 12, no. 9, 1356, pp. 1-14. https://doi.org/10.3390/genes12091356

APA

Ziegler, G. C., Ehlis, A-C., Weber, H., Vitale, M. R., Zöller, J. E. M., Ku, H-P., Schiele, M. A., Kürbitz, L., Romanos, M., Pauli, P., Kalisch, R., Zwanzger, P., Domschke, K., Fallgatter, A. J., Reif, A., & Lesch, K-P. (2021). A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD. GENES-BASEL, 12(9), 1-14. [1356]. https://doi.org/10.3390/genes12091356

Vancouver

Ziegler GC, Ehlis A-C, Weber H, Vitale MR, Zöller JEM, Ku H-P et al. A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD. GENES-BASEL. 2021 Aug 29;12(9):1-14. 1356. https://doi.org/10.3390/genes12091356

Bibtex

@article{e0e72c3b9cdf432590b8ac1aa957cf39,
title = "A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD",
abstract = "The cell-cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse. Therefore, we tested for association of a functional intronic CDH13 SNP rs2199430 with ADHD in a sample of 998 adult patients and 884 healthy controls. The Big Five personality traits were assessed by the NEO-PI-R questionnaire. Assuming that altered neural correlates of working memory and cognitive response inhibition show genotype-dependent alterations, task performance and electroencephalographic event-related potentials were measured by n-back and continuous performance (Go/NoGo) tasks. The rs2199430 genotype was not associated with adult ADHD on the categorical diagnosis level. However, rs2199430 was significantly associated with agreeableness, with minor G allele homozygotes scoring lower than A allele carriers. Whereas task performance was not affected by genotype, a significant heterosis effect limited to the ADHD group was identified for the n-back task. Heterozygotes (AG) exhibited significantly higher N200 amplitudes during both the 1-back and 2-back condition in the central electrode position Cz. Consequently, the common genetic variation of CDH13 is associated with personality traits and impacts neural processing during working memory tasks. Thus, CDH13 might contribute to symptomatic core dysfunctions of social and cognitive impairment in ADHD.",
author = "Ziegler, {Georg C.} and Ann-Christine Ehlis and Heike Weber and Vitale, {Maria Rosaria} and Z{\"o}ller, {Johanne E. M.} and Hsing-Ping Ku and Schiele, {Miriam A.} and Laura K{\"u}rbitz and Marcel Romanos and Paul Pauli and Raffael Kalisch and Peter Zwanzger and Katharina Domschke and Fallgatter, {Andreas J.} and Andreas Reif and Klaus-Peter Lesch",
year = "2021",
month = aug,
day = "29",
doi = "10.3390/genes12091356",
language = "English",
volume = "12",
pages = "1--14",
journal = "GENES-BASEL",
issn = "2073-4425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

RIS

TY - JOUR

T1 - A common CDH13 variant is associated with low agreeableness and neural responses to working memory tasks in ADHD

AU - Ziegler, Georg C.

AU - Ehlis, Ann-Christine

AU - Weber, Heike

AU - Vitale, Maria Rosaria

AU - Zöller, Johanne E. M.

AU - Ku, Hsing-Ping

AU - Schiele, Miriam A.

AU - Kürbitz, Laura

AU - Romanos, Marcel

AU - Pauli, Paul

AU - Kalisch, Raffael

AU - Zwanzger, Peter

AU - Domschke, Katharina

AU - Fallgatter, Andreas J.

AU - Reif, Andreas

AU - Lesch, Klaus-Peter

PY - 2021/8/29

Y1 - 2021/8/29

N2 - The cell-cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse. Therefore, we tested for association of a functional intronic CDH13 SNP rs2199430 with ADHD in a sample of 998 adult patients and 884 healthy controls. The Big Five personality traits were assessed by the NEO-PI-R questionnaire. Assuming that altered neural correlates of working memory and cognitive response inhibition show genotype-dependent alterations, task performance and electroencephalographic event-related potentials were measured by n-back and continuous performance (Go/NoGo) tasks. The rs2199430 genotype was not associated with adult ADHD on the categorical diagnosis level. However, rs2199430 was significantly associated with agreeableness, with minor G allele homozygotes scoring lower than A allele carriers. Whereas task performance was not affected by genotype, a significant heterosis effect limited to the ADHD group was identified for the n-back task. Heterozygotes (AG) exhibited significantly higher N200 amplitudes during both the 1-back and 2-back condition in the central electrode position Cz. Consequently, the common genetic variation of CDH13 is associated with personality traits and impacts neural processing during working memory tasks. Thus, CDH13 might contribute to symptomatic core dysfunctions of social and cognitive impairment in ADHD.

AB - The cell-cell signaling gene CDH13 is associated with a wide spectrum of neuropsychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD), autism, and major depression. CDH13 regulates axonal outgrowth and synapse formation, substantiating its relevance for neurodevelopmental processes. Several studies support the influence of CDH13 on personality traits, behavior, and executive functions. However, evidence for functional effects of common gene variation in the CDH13 gene in humans is sparse. Therefore, we tested for association of a functional intronic CDH13 SNP rs2199430 with ADHD in a sample of 998 adult patients and 884 healthy controls. The Big Five personality traits were assessed by the NEO-PI-R questionnaire. Assuming that altered neural correlates of working memory and cognitive response inhibition show genotype-dependent alterations, task performance and electroencephalographic event-related potentials were measured by n-back and continuous performance (Go/NoGo) tasks. The rs2199430 genotype was not associated with adult ADHD on the categorical diagnosis level. However, rs2199430 was significantly associated with agreeableness, with minor G allele homozygotes scoring lower than A allele carriers. Whereas task performance was not affected by genotype, a significant heterosis effect limited to the ADHD group was identified for the n-back task. Heterozygotes (AG) exhibited significantly higher N200 amplitudes during both the 1-back and 2-back condition in the central electrode position Cz. Consequently, the common genetic variation of CDH13 is associated with personality traits and impacts neural processing during working memory tasks. Thus, CDH13 might contribute to symptomatic core dysfunctions of social and cognitive impairment in ADHD.

UR - https://www.mdpi.com/2073-4425/12/9/1356

U2 - 10.3390/genes12091356

DO - 10.3390/genes12091356

M3 - SCORING: Journal article

VL - 12

SP - 1

EP - 14

JO - GENES-BASEL

JF - GENES-BASEL

SN - 2073-4425

IS - 9

M1 - 1356

ER -