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A case of severe Ebola virus infection complicated by gram-negative septicemia

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A case of severe Ebola virus infection complicated by gram-negative septicemia. / Kreuels, Benno; Wichmann, Dominic; Emmerich, Petra; Schmidt-Chanasit, Jonas; Heer, Geraldine; Kluge, Stefan; Sow, Abdourahmane; Renné, Thomas; Günther, Stephan; Lohse, Ansgar W; Addo, Marylyn Martina; Schmiedel, Stefan.

In: NEW ENGL J MED, Vol. 371, No. 25, 18.12.2014, p. 2394-401.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kreuels, B, Wichmann, D, Emmerich, P, Schmidt-Chanasit, J, Heer, G, Kluge, S, Sow, A, Renné, T, Günther, S, Lohse, AW, Addo, MM & Schmiedel, S 2014, 'A case of severe Ebola virus infection complicated by gram-negative septicemia', NEW ENGL J MED, vol. 371, no. 25, pp. 2394-401. https://doi.org/10.1056/NEJMoa1411677

APA

Kreuels, B., Wichmann, D., Emmerich, P., Schmidt-Chanasit, J., Heer, G., Kluge, S., Sow, A., Renné, T., Günther, S., Lohse, A. W., Addo, M. M., & Schmiedel, S. (2014). A case of severe Ebola virus infection complicated by gram-negative septicemia. NEW ENGL J MED, 371(25), 2394-401. https://doi.org/10.1056/NEJMoa1411677

Vancouver

Kreuels B, Wichmann D, Emmerich P, Schmidt-Chanasit J, Heer G, Kluge S et al. A case of severe Ebola virus infection complicated by gram-negative septicemia. NEW ENGL J MED. 2014 Dec 18;371(25):2394-401. https://doi.org/10.1056/NEJMoa1411677

Bibtex

@article{a9e011544ac04d9bba0e95aa0ff72b6c,
title = "A case of severe Ebola virus infection complicated by gram-negative septicemia",
abstract = "Ebola virus disease (EVD) developed in a patient who contracted the disease in Sierra Leone and was airlifted to an isolation facility in Hamburg, Germany, for treatment. During the course of the illness, he had numerous complications, including septicemia, respiratory failure, and encephalopathy. Intensive supportive treatment consisting of high-volume fluid resuscitation (approximately 10 liters per day in the first 72 hours), broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies. Discharge was delayed owing to the detection of viral RNA in urine (day 30) and sweat (at the last assessment on day 40) by means of polymerase-chain-reaction (PCR) assay, but the last positive culture was identified in plasma on day 14 and in urine on day 26. This case shows the challenges in the management of EVD and suggests that even severe EVD can be treated effectively with routine intensive care.",
keywords = "Adult, Anti-Infective Agents, Bacteremia, Diarrhea, Ebolavirus, Fluid Therapy, Gram-Negative Bacterial Infections, Hemorrhagic Fever, Ebola, Hepatitis B, Chronic, Humans, Intensive Care, Male, Parenteral Nutrition, RNA, Viral, Sierra Leone, Viral Load",
author = "Benno Kreuels and Dominic Wichmann and Petra Emmerich and Jonas Schmidt-Chanasit and Geraldine Heer and Stefan Kluge and Abdourahmane Sow and Thomas Renn{\'e} and Stephan G{\"u}nther and Lohse, {Ansgar W} and Addo, {Marylyn Martina} and Stefan Schmiedel",
year = "2014",
month = dec,
day = "18",
doi = "10.1056/NEJMoa1411677",
language = "English",
volume = "371",
pages = "2394--401",
journal = "NEW ENGL J MED",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "25",

}

RIS

TY - JOUR

T1 - A case of severe Ebola virus infection complicated by gram-negative septicemia

AU - Kreuels, Benno

AU - Wichmann, Dominic

AU - Emmerich, Petra

AU - Schmidt-Chanasit, Jonas

AU - Heer, Geraldine

AU - Kluge, Stefan

AU - Sow, Abdourahmane

AU - Renné, Thomas

AU - Günther, Stephan

AU - Lohse, Ansgar W

AU - Addo, Marylyn Martina

AU - Schmiedel, Stefan

PY - 2014/12/18

Y1 - 2014/12/18

N2 - Ebola virus disease (EVD) developed in a patient who contracted the disease in Sierra Leone and was airlifted to an isolation facility in Hamburg, Germany, for treatment. During the course of the illness, he had numerous complications, including septicemia, respiratory failure, and encephalopathy. Intensive supportive treatment consisting of high-volume fluid resuscitation (approximately 10 liters per day in the first 72 hours), broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies. Discharge was delayed owing to the detection of viral RNA in urine (day 30) and sweat (at the last assessment on day 40) by means of polymerase-chain-reaction (PCR) assay, but the last positive culture was identified in plasma on day 14 and in urine on day 26. This case shows the challenges in the management of EVD and suggests that even severe EVD can be treated effectively with routine intensive care.

AB - Ebola virus disease (EVD) developed in a patient who contracted the disease in Sierra Leone and was airlifted to an isolation facility in Hamburg, Germany, for treatment. During the course of the illness, he had numerous complications, including septicemia, respiratory failure, and encephalopathy. Intensive supportive treatment consisting of high-volume fluid resuscitation (approximately 10 liters per day in the first 72 hours), broad-spectrum antibiotic therapy, and ventilatory support resulted in full recovery without the use of experimental therapies. Discharge was delayed owing to the detection of viral RNA in urine (day 30) and sweat (at the last assessment on day 40) by means of polymerase-chain-reaction (PCR) assay, but the last positive culture was identified in plasma on day 14 and in urine on day 26. This case shows the challenges in the management of EVD and suggests that even severe EVD can be treated effectively with routine intensive care.

KW - Adult

KW - Anti-Infective Agents

KW - Bacteremia

KW - Diarrhea

KW - Ebolavirus

KW - Fluid Therapy

KW - Gram-Negative Bacterial Infections

KW - Hemorrhagic Fever, Ebola

KW - Hepatitis B, Chronic

KW - Humans

KW - Intensive Care

KW - Male

KW - Parenteral Nutrition

KW - RNA, Viral

KW - Sierra Leone

KW - Viral Load

U2 - 10.1056/NEJMoa1411677

DO - 10.1056/NEJMoa1411677

M3 - SCORING: Journal article

C2 - 25337633

VL - 371

SP - 2394

EP - 2401

JO - NEW ENGL J MED

JF - NEW ENGL J MED

SN - 0028-4793

IS - 25

ER -