A 76-year-old woman with paraplegia
Standard
A 76-year-old woman with paraplegia. / Rémi, Jan; Pfefferkorn, Thomas; König, Fatima B; Lassmann, Hans; Brück, Wolfgang; Holtmannspötter, Markus; Straube, Andreas; Kretzschmar, Hans A; Schüller, Ulrich.
In: BRAIN PATHOL, Vol. 20, No. 2, 03.2010, p. 507-10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - A 76-year-old woman with paraplegia
AU - Rémi, Jan
AU - Pfefferkorn, Thomas
AU - König, Fatima B
AU - Lassmann, Hans
AU - Brück, Wolfgang
AU - Holtmannspötter, Markus
AU - Straube, Andreas
AU - Kretzschmar, Hans A
AU - Schüller, Ulrich
PY - 2010/3
Y1 - 2010/3
N2 - A-76-year old woman was admitted to the hospital with paraplegia after a collapse at home. Magnetic resonance imaging showed white matter lesions from Th4 to L2 as well as large confluent white matter lesions in the cerebrum. Within 3 days, the patient's mental status decreased dramatically and she finally died on day 16 after her fall. Autopsy examination revealed an acute myeloid leukemia, which had not previously been diagnosed and which had never been treated. In the CNS, we found spread of myeloblasts in combination with acute demyelinating lesions which corresponded to the antibody- and complement-mediated pattern II of multiple sclerosis lesions. This case implies that association of acute myeloid leukemia and acute CNS demyelination needs to be discussed and suggests that AML patients need to be strictly monitored for CNS functions.
AB - A-76-year old woman was admitted to the hospital with paraplegia after a collapse at home. Magnetic resonance imaging showed white matter lesions from Th4 to L2 as well as large confluent white matter lesions in the cerebrum. Within 3 days, the patient's mental status decreased dramatically and she finally died on day 16 after her fall. Autopsy examination revealed an acute myeloid leukemia, which had not previously been diagnosed and which had never been treated. In the CNS, we found spread of myeloblasts in combination with acute demyelinating lesions which corresponded to the antibody- and complement-mediated pattern II of multiple sclerosis lesions. This case implies that association of acute myeloid leukemia and acute CNS demyelination needs to be discussed and suggests that AML patients need to be strictly monitored for CNS functions.
KW - Acute Disease
KW - Aged
KW - Brain
KW - Demyelinating Diseases
KW - Diagnosis, Differential
KW - Fatal Outcome
KW - Female
KW - Humans
KW - Leukemia, Myeloid, Acute
KW - Paraplegia
KW - Case Reports
KW - Letter
U2 - 10.1111/j.1750-3639.2009.00362.x
DO - 10.1111/j.1750-3639.2009.00362.x
M3 - SCORING: Journal article
C2 - 20438471
VL - 20
SP - 507
EP - 510
JO - BRAIN PATHOL
JF - BRAIN PATHOL
SN - 1015-6305
IS - 2
ER -