3D cerebrovascular segmentation combining fuzzy vessel enhancement and level-sets with anisotropic energy weights
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3D cerebrovascular segmentation combining fuzzy vessel enhancement and level-sets with anisotropic energy weights. / Forkert, Nils Daniel; Schmidt-Richberg, Alexander; Fiehler, Jens; Illies, Till; Möller, Dietmar; Säring, Dennis; Handels, Heinz; Ehrhardt, Jan.
In: MAGN RESON IMAGING, Vol. 31, No. 2, 01.02.2013, p. 262-71.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - 3D cerebrovascular segmentation combining fuzzy vessel enhancement and level-sets with anisotropic energy weights
AU - Forkert, Nils Daniel
AU - Schmidt-Richberg, Alexander
AU - Fiehler, Jens
AU - Illies, Till
AU - Möller, Dietmar
AU - Säring, Dennis
AU - Handels, Heinz
AU - Ehrhardt, Jan
N1 - Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2013/2/1
Y1 - 2013/2/1
N2 - The aim of this work is to present and evaluate a level-set segmentation approach with vesselness-dependent anisotropic energy weights, which focuses on the exact segmentation of malformed as well as small vessels from time-of-flight (TOF) magnetic resonance angiography (MRA) datasets. In a first step, a vesselness filter is used to calculate the vesselness dataset, which quantifies the likeliness of each voxel to belong to a bright tubular-shaped structure and estimate the corresponding vessel directions from a given TOF dataset. The vesselness and TOF datasets are then combined using fuzzy-logic and used for initialization of a variational level-set method. The proposed level-set model has been extended in a way that the weight of the internal energy is locally adapted based on the vessel direction information. Here, the main idea is to weight the internal energy lower if the gradient direction of the level-set is similar to the direction of the eigenvector extracted by the vesselness filter. Furthermore, an additional vesselness force has been integrated in the level-set formulation. The proposed method was evaluated based on ten TOF MRA datasets from patients with an arteriovenous malformation. Manual segmentations from two observers were available for each dataset and used for quantitative comparison. The evaluation revealed that the proposed method yields significantly better segmentation results than four other state-of-the-art segmentation methods tested. Furthermore, the segmentation results are within the range of the inter-observer variation. In conclusion, the proposed method allows an improved delineation of small vessels, especially of those represented by low intensities and high surface curvatures.
AB - The aim of this work is to present and evaluate a level-set segmentation approach with vesselness-dependent anisotropic energy weights, which focuses on the exact segmentation of malformed as well as small vessels from time-of-flight (TOF) magnetic resonance angiography (MRA) datasets. In a first step, a vesselness filter is used to calculate the vesselness dataset, which quantifies the likeliness of each voxel to belong to a bright tubular-shaped structure and estimate the corresponding vessel directions from a given TOF dataset. The vesselness and TOF datasets are then combined using fuzzy-logic and used for initialization of a variational level-set method. The proposed level-set model has been extended in a way that the weight of the internal energy is locally adapted based on the vessel direction information. Here, the main idea is to weight the internal energy lower if the gradient direction of the level-set is similar to the direction of the eigenvector extracted by the vesselness filter. Furthermore, an additional vesselness force has been integrated in the level-set formulation. The proposed method was evaluated based on ten TOF MRA datasets from patients with an arteriovenous malformation. Manual segmentations from two observers were available for each dataset and used for quantitative comparison. The evaluation revealed that the proposed method yields significantly better segmentation results than four other state-of-the-art segmentation methods tested. Furthermore, the segmentation results are within the range of the inter-observer variation. In conclusion, the proposed method allows an improved delineation of small vessels, especially of those represented by low intensities and high surface curvatures.
KW - Algorithms
KW - Anisotropy
KW - Automatic Data Processing
KW - Automation
KW - Cerebrovascular Circulation
KW - Fuzzy Logic
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Imaging, Three-Dimensional
KW - Magnetic Resonance Angiography
KW - Magnetic Resonance Spectroscopy
KW - Models, Statistical
KW - Observer Variation
KW - Reproducibility of Results
KW - Signal Processing, Computer-Assisted
KW - Surface Properties
U2 - 10.1016/j.mri.2012.07.008
DO - 10.1016/j.mri.2012.07.008
M3 - SCORING: Journal article
C2 - 22917500
VL - 31
SP - 262
EP - 271
JO - MAGN RESON IMAGING
JF - MAGN RESON IMAGING
SN - 0730-725X
IS - 2
ER -