18F-FDG PET/CT for Detection of Leukemic Transformation in Myelofibrosis
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18F-FDG PET/CT for Detection of Leukemic Transformation in Myelofibrosis. / Derlin, Thorsten; Clauditz, Till Sebastian; Kröger, Nicolaus.
In: CLIN NUCL MED, Vol. 40, No. 6, 06.2015, p. 521-2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - 18F-FDG PET/CT for Detection of Leukemic Transformation in Myelofibrosis
AU - Derlin, Thorsten
AU - Clauditz, Till Sebastian
AU - Kröger, Nicolaus
PY - 2015/6
Y1 - 2015/6
N2 - Myelofibrosis is a rare clonal hematopoietic stem cell disorder characterized by chronic myeloproliferation, atypical megakaryocytic hyperplasia, and potential leukemic transformation. We report a case of leukemic transformation detected by F-FDG PET/CT. A 56-year-old woman with myelofibrosis and newly diagnosed space-occupying lesion of the chest wall underwent whole-body PET/CT for further evaluation. F-FDG PET demonstrated marked tracer uptake within that lesion. Histopathological evaluation revealed myeloid sarcoma evidencing leukemic transformation. F-FDG PET/CT is a valuable tool-enabling sensitive detection of leukemic transformation in myelofibrosis, particularly in case of extramedullary organ involvement.
AB - Myelofibrosis is a rare clonal hematopoietic stem cell disorder characterized by chronic myeloproliferation, atypical megakaryocytic hyperplasia, and potential leukemic transformation. We report a case of leukemic transformation detected by F-FDG PET/CT. A 56-year-old woman with myelofibrosis and newly diagnosed space-occupying lesion of the chest wall underwent whole-body PET/CT for further evaluation. F-FDG PET demonstrated marked tracer uptake within that lesion. Histopathological evaluation revealed myeloid sarcoma evidencing leukemic transformation. F-FDG PET/CT is a valuable tool-enabling sensitive detection of leukemic transformation in myelofibrosis, particularly in case of extramedullary organ involvement.
U2 - 10.1097/RLU.0000000000000728
DO - 10.1097/RLU.0000000000000728
M3 - SCORING: Journal article
C2 - 25674874
VL - 40
SP - 521
EP - 522
JO - CLIN NUCL MED
JF - CLIN NUCL MED
SN - 0363-9762
IS - 6
ER -