γδ T cells license immature B cells to produce a broad range of polyreactive antibodies
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Abstract
Immature autoreactive B cells are present in all healthy individuals, but it is unclear which signals are required for their maturation into antibody-producing cells. Inducible depletion of γδ T cells show that direct interaction between γδ T cells and immature B cells in the spleen support an "innate" transition to mature B cells with a broad range of antigen specificities. IL-4 production of γδ T cells and cell-to-cell contact via CD30L support B cell maturation and induce genes of the unfolded protein response and mTORC1 signaling. Eight days after in vivo depletion of γδ T cells, increased numbers of B cells are already stuck in the transitional phase and express increased levels of IgD and CD21. Absence of γδ T cells leads also to reduced levels of serum anti-nuclear autoantibodies, making γδ T cells an attractive target to treat autoimmunity.
Bibliographical data
Original language | English |
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Article number | 110854 |
ISSN | 2211-1247 |
DOIs | |
Publication status | Published - 24.05.2022 |
Comment Deanary
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
PubMed | 35613579 |
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