УНИВЕРСАЛЬНАЯ МОДУЛЬНАЯ СИСТЕМА СКРИНИНГА IN VITRO ПОТЕНЦИАЛЬНЫХ ИНГИБИТОРОВ РЕПЛИКАЦИИ ВИЧ-1

M M Prokof'eva; N N Orlova; A S Gornostaeva; A A Shul'gin; N A Nikitenko; V N Senchenko; T D Lebedev; P V Spirin; Kristoffer Riecken; B Fehse; C Stocking; V S Prasolov

УНИВЕРСАЛЬНАЯ МОДУЛЬНАЯ СИСТЕМА СКРИНИНГА IN VITRO ПОТЕНЦИАЛЬНЫХ ИНГИБИТОРОВ РЕПЛИКАЦИИ ВИЧ-1

M M Prokof'eva
N N Orlova
A S Gornostaeva
A A Shul'gin
N A Nikitenko
V N Senchenko
T D Lebedev
P V Spirin
Kristoffer Riecken
B Fehse
C Stocking
V S Prasolov

Related Research units

Department of Stem Cell Transplantation

Abstract

Here we describe a system based on recombinant lentiviral vectors for the safe screening of potential anti-HIV drugs. The system allows to evaluate the sensitivity of HIVl-1 reverse transcriptase and integrase (wild-type as well as mutant forms of these enzymes detected in drug-resistant virus isolates) towards different drugs and substances, but also to screen inhibitors of other stages of HIV-1 life cycle.

Bibliographical data

Translated title of the contribution	Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication
Original language	Russian
ISSN	0026-8984
Publication status	Published - 09.04.2015

PubMed	25850304