13XP5060B MAGneTISe
Project: Research
Participants
- Knopp, Tobias (principal investigator)
- Ludewig, Peter (principal investigator)
Schools
Bibliographical data
Description
This new imaging technique enables rapid assessment of cerebral perfusion (real-time-MPI), as well as the steering of superparamagnetic iron oxide nanoparticles (SPIO) by magnetic fields (force-MPI). We will develop strategies for continuous bedside cerebral perfusion monitoring, using red blood cells (RBC) as a biomimetic tracer-delivery system for the SPIOs, which otherwise would have been quickly eliminated. This method will enable rapid diagnosis of stroke or bleeding and facilitate faster treatment and better patient outcomes. Using
the magnetic fields of the MPI system, we will trap the coupled nanoparticles in the occluded vessel, which will locally increase the amount of active enzyme, resulting in an increased rate of successful revascularization while decreasing systemic side effects.
Acronym | MAGneTISe |
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Status | Finished |
Effective start/end date | 01.08.18 → 31.12.22 |