ID: 62859

Jakob Körbelin

Group leader

graph of relations

Publications

  1. Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

    Alvarez-Vergara, M. I., Rosales-Nieves, A. E., March-Diaz, R., Rodriguez-Perinan, G., Lara-Ureña, N., Ortega-de San Luis, C., Sanchez-Garcia, M. A., Martin-Bornez, M., Gómez-Gálvez, P., Vicente-Munuera, P., Fernandez-Gomez, B., Marchena, M. A., Bullones-Bolanos, A. S., Davila, J. C., Gonzalez-Martinez, R., Trillo-Contreras, J. L., Sanchez-Hidalgo, A. C., Del Toro, R., Scholl, F. G., Herrera, E., Trepel, M., Körbelin, J., Escudero, L. M., Villadiego, J., Echevarria, M., de Castro, F., Gutierrez, A., Rabano, A., Vitorica, J. & Pascual, A., 25.05.2021, In: NAT COMMUN. 12, 1, 3098.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  2. Genetic manipulation of brain endothelial cells in vivo

    Assmann, J. C., Körbelin, J. & Schwaninger, M., 03.2016, In: BBA-MOL BASIS DIS. 1862, 3, p. 381-94

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown

    Aydin, S., Pareja, J., Schallenberg, V. M., Klopstein, A., Gruber, T., Page, N., Bouillet, E., Blanchard, N., Liblau, R., Körbelin, J., Schwaninger, M., Johnson, A. J., Schenk, M., Deutsch, U., Merkler, D. & Engelhardt, B., 30.05.2023, In: NAT COMMUN. 14, 1, 3106.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. Novel Gene Therapy Approaches for Whole Brain Delivery of the Lysosomal Gcase Enzyme for Wide Protection from Alpha-Synuclein Toxic Aggregates

    Broccoli, V., Ordozza, G., Bido, S., Valtorta, M., Morabito, G., Körbelin, J., Cacellieri, C. & Giannelli, S., 05.2018, In: MOL THER. 26, 5 Suppl., p. 131-131 278.

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  5. Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling

    Chen, D-Y., Sun, N-H., Chen, X., Gong, J-J., Yuan, S-T., Hu, Z-Z., Lu, N-N., Körbelin, J., Fukunaga, K., Liu, Q-H., Lu, Y-M. & Han, F., 15.02.2021, In: J CLIN INVEST. 131, 4, e135296.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  6. Gene Therapy Decreases Seizures in a Model of Incontinentia Pigmenti

    Dogbevia, G. K., Töllner, K., Körbelin, J., Bröer, S., Ridder, D. A., Grasshoff, H., Brandt, C., Wenzel, J., Straub, B. K., Trepel, M., Löscher, W. & Schwaninger, M., 07.2017, In: ANN NEUROL. 82, 1, p. 93-104

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  7. Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors

    Eichhoff, A. M., Börner, K., Albrecht, B., Schäfer, W., Baum, N., Haag, F., Körbelin, J., Trepel, M., Braren, I., Grimm, D., Adriouch, S. & Koch-Nolte, F., 13.12.2019, In: MOL THER-METH CLIN D. 15, p. 211-220 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  8. Identification of New Adeno-Associated Virus 9 (AAV9) Capsid Variants Targeting the BALB/c Mouse Brain through Directed Evolution

    Giannelli, SG., Luoni, M., Conti, E., Niro, A., Trepel, M., Körbelin, J. & Broccoli, V., 17.05.2021, In: MOL THER. 29, 4, p. 149-150 2 p.

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  9. Short regulatory DNA sequences to target brain endothelial cells for gene therapy

    Graßhoff, H., Müller-Fielitz, H., Dogbevia, G. K., Körbelin, J., Bannach, J., Vahldieck, C. M., Kusche-Vihrog, K., Jöhren, O., Müller, O. J., Nogueiras, R., Prevot, V. & Schwaninger, M., 01.2022, In: J CEREBR BLOOD F MET. 42, 1, p. 104-120 17 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  10. Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of NPC2 disease

    Hede, E., Heegaard, C., Körbelin, J., Schwaninger, M., Moos, T. & Burkhart, A., 01.11.2019, In: HUM GENE THER. 2019, 30

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  11. The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension

    Hennigs, J. K., Lüneburg, N., Stage, A., Schmitz, M., Körbelin, J., Harbaum, L., Matuszcak, C., Mienert, J., Bokemeyer, C., Böger, R. H., Kiefmann, R. & Klose, H., 09.2019, In: PURINERG SIGNAL. 15, 3, p. 299-311 13 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension

    Hennigs, J. K., Cao, A., Li, C. G., Shi, M., Mienert, J., Miyagawa, K., Körbelin, J., Marciano, D. P., Chen, P-I., Roughley, M., Elliott, M. V., Harper, R. L., Bill, M. A., Chappell, J., Moonen, J-R., Diebold, I., Wang, L., Snyder, M. P. & Rabinovitch, M., 05.02.2021, In: CIRC RES. 128, 3, p. 401-418 18 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  13. Vascular Endothelial Cells: Heterogeneity and Targeting Approaches

    Hennigs, J. K., Matuszcak, C., Trepel, M. & Körbelin, J., 10.10.2021, In: CELLS-BASEL. 10, 10, p. 2712

    Research output: SCORING: Contribution to journalSCORING: Review articleResearch

  14. Respiratory muscle dysfunction in long-COVID patients

    Hennigs, J. K., Huwe, M., Hennigs, A., Oqueka, T., Simon, M., Harbaum, L., Körbelin, J., Schmiedel, S., Schulze Zur Wiesch, J., Addo, M. M., Kluge, S. & Klose, H., 10.2022, In: INFECTION. 50, 5, p. 1391-1397 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  15. Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

    Isobe, S., Nair, R. V., Kang, H. Y., Wang, L., Moonen, J-R., Shinohara, T., Cao, A., Taylor, S., Otsuki, S., Marciano, D. P., Harper, R. L., Adil, M. S., Zhang, C., Lago-Docampo, M., Körbelin, J., Engreitz, J. M., Snyder, M. P. & Rabinovitch, M., 21.11.2023, In: NAT COMMUN. 14, 1, 7578.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43

    Ivanova, E., Corona, C., Eleftheriou, C. G., Stout, R. F., Körbelin, J. & Sagdullaev, B. T., 30.03.2022, In: J COMP NEUROL. 530, 8, p. 1302-1317 16 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  17. A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS

    Johann, L., Soldati, S., Müller, K., Lampe, J., Marini, F., Klein, M., Schramm, E., Ries, N., Schelmbauer, C., Palagi, I., Karram, K., Assmann, J. C., Khan, M. A., Wenzel, J., Schmidt, M. H., Körbelin, J., Schlüter, D., van Loo, G., Bopp, T., Engelhardt, B., Schwaninger, M. & Waisman, A., 15.12.2023, In: J CLIN INVEST. 133, 24, e168314.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. The complete sequence of tobacco mosaic virus isolate Ohio V reveals a high accumulation of silent mutations in all open reading frames

    Körbelin, J., Willingmann, P., Adam, G. & Heinze, C., 01.02.2012, In: ARCH VIROL. 157, 2, p. 387-9 3 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  19. Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries

    Körbelin, J., Sieber, T., Michelfelder, S., Lunding, L., Spies, E., Hunger, A., Alawi, M., Rapti, K., Indenbirken, D., Müller, O. J., Pasqualini, R., Arap, W., Kleinschmidt, J. A. & Trepel, M., 06.2016, In: MOL THER. 24, 6, p. 1050-61

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  20. A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases

    Körbelin, J., Dogbevia, G., Michelfelder, S., Ridder, D. A., Hunger, A., Wenzel, J., Seismann, H., Lampe, M., Bannach, J., Pasparakis, M., Kleinschmidt, J. A., Schwaninger, M. & Trepel, M., 01.06.2016, In: EMBO MOL MED. 8, 6, p. 609-25

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  21. Vascular-targeted recombinant adeno-associated viral vectors for the treatment of rare diseases

    Körbelin, J., Schwaninger, M. & Trepel, M., 10.08.2016, In: Rare Diseases. 4, 1

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  22. How to successfully screen random AAV display peptide libraries in vivo

    Körbelin, J. & Trepel, M., 06.2017, In: HUM GENE THER METHOD. 28, 3, p. 109-123

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Optimization of design and production strategies for novel adeno-associated viral display peptide libraries

    Körbelin, J., Hunger, A., Alawi, M., Sieber, T., Binder, M. & Trepel, M., 08.2017, In: GENE THER. 24, 8, p. 470-481

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. Viral vector for the targeted transfer of genes in the brain and spinal cord

    Körbelin, J., Michelfelder, S. & Trepel, M., 02.02.2017, IPC No. PCT/EP2015/058123, Priority date 17.04.2014

    Research output: Patent

  25. Assessing the transduction profile of the brain-endothelial directed gene vector AAV-BR1

    Körbelin, J., Kleint, M., Dogbevia, G., Ohnmacht, J., Trepel, M. & Schwaninger, M., 02.2018, In: N-S ARCH PHARMACOL. 391, P36.

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  26. Brain Endothelial-Targeted Gene Therapy in a Mouse Model of Incontinentia Pigmenti

    Körbelin, J., Dogbevia, G., Töllner, K., Bröer, S., Ridder, D., Grasshoff, H., Brandt, C., Straub, B., Trepel, M., Löscher, W. & Schwaninger, M., 05.2017, In: MOL THER. 25, 5, p. 256-257

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  27. Transcription factors in the pathogenesis of pulmonary arterial hypertension-Current knowledge and therapeutic potential

    Körbelin, J., Matuszcak, C., Runge, J., Harbaum, L., Klose, H. & Hennigs, J. K., 06.01.2023, In: FRONT CARDIOVASC MED. 9, p. 1036096

    Research output: SCORING: Contribution to journalSCORING: Review articleResearch

  28. Inactivation of Adeno-Associated Viral Vectors by Oxidant-Based Disinfectants

    Korte, J., Mienert, J., Hennigs, J. K. & Körbelin, J., 07.2021, In: HUM GENE THER. 32, 13-14, p. 771-781 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  29. Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair

    Mehina, E. M. F., Taylor, S., Boghozian, R., White, E., Choi, S. E., Cheema, M. S., Korbelin, J. & Brown, C. E., 08.2021, In: SCI ADV. 7, 34

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.

    Michelfelder, S., Varadi, K., Raupp, C., Hunger, A., Körbelin, J., Pahrmann, C., Schrepfer, S., Müller, O. J., Kleinschmidt, J. A. & Trepel, M., 2011, In: PLOS ONE. 6, 8, p. 23101 8.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  31. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A

    Nikolakopoulou, A. M., Wang, Y., Ma, Q., Sagare, A. P., Montagne, A., Huuskonen, M. T., Rege, S. V., Kisler, K., Dai, Z., Körbelin, J., Herz, J., Zhao, Z. & Zlokovic, B. V., 05.04.2021, In: J EXP MED. 218, 4, e20202207.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  32. The HDL particle composition determines its antitumor activity in pancreatic cancer

    Oberle, R., Kührer, K., Österreicher, T., Weber, F., Steinbauer, S., Udonta, F., Wroblewski, M., Ben-Batalla, I., Hassl, I., Körbelin, J., Unseld, M., Jauhiainen, M., Plochberger, B., Röhrl, C., Hengstschläger, M., Loges, S. & Stangl, H., 09.2022, In: LIFE SCI ALLIANCE. 5, 9, e202101317.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  33. Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice

    Park, E. S., Kim, S., Huang, S., Yoo, J. Y., Körbelin, J., Lee, T. J., Kaur, B., Dash, P. K., Chen, P. R. & Kim, E., 05.2021, In: ANN NEUROL. 89, 5, p. 926-941 16 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus

    Rasmussen, C. L. M., Hede, E., Routhe, L. J., Körbelin, J., Helgudottir, S. S., Thomsen, L. B., Schwaninger, M., Burkhart, A. & Moos, T., 01.2023, In: J NEUROCHEM. 164, 1, p. 6-28 23 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension

    Remes, A., Körbelin, J., Arnold, C., Rohwedder, C., Heckmann, M. B., Mairbauerl, H., Frank, D., Korff, T., Frey, N., Trepel, M. & Müller, O. J., 09.2022, In: HUM GENE THER. 33, 17-18, p. 959-967 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  36. PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

    Ren, A. A., Snellings, D. A., Su, Y. S., Hong, C. C., Castro, M., Tang, A. T., Detter, M. R., Hobson, N., Girard, R., Romanos, S., Lightle, R., Moore, T., Shenkar, R., Benavides, C., Beaman, M. M., Mueller-Fielitz, H., Chen, M., Mericko, P., Yang, J., Sung, D. C., Lawton, M. T., Ruppert, M., Schwaninger, M., Körbelin, J., Potente, M., Awad, I. A., Marchuk, D. A. & Kahn, M. L., 06.2021, In: NATURE. 594, 7862, p. 271-276 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations

    Ren, J., Huang, Y., Ren, Y., Tu, T., Qiu, B., Ai, D., Bi, Z., Bai, X., Li, F., Li, J-L., Chen, X-J., Feng, Z., Guo, Z., Lei, J., Tian, A., Cui, Z., Lindner, V., Adams, R. H., Wang, Y., Zhao, F., Körbelin, J., Sun, W., Wang, Y., Zhang, H., Hong, T. & Ge, W-P., 01.09.2023, In: BRAIN. 146, 9, p. 3634-3647 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

    Santisteban, M. M., Ahn, S. J., Lane, D., Faraco, G., Garcia-Bonilla, L., Racchumi, G., Poon, C., Schaeffer, S., Segarra, S. G., Körbelin, J., Anrather, J. & Iadecola, C., 09.2020, In: HYPERTENSION. 76, 3, p. 795-807 13 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. Identification of New AAV9 Engineered Capsids Targeting Mouse and Monkey Brains Through a Directed Evolution Approach in BALB/c Mice

    Serena, GG., Luoni, M., Bellinazzi, B., Martin, T., Körbelin, J. & Broccoli, V., 07.06.2022, In: MOL THER. 30, 4, p. 209-210 2 p.

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  40. Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

    Sundaram, S. M., Arrulo Pereira, A., Müller-Fielitz, H., Köpke, H., De Angelis, M., Müller, T. D., Heuer, H., Körbelin, J., Krohn, M., Mittag, J., Nogueiras, R., Prevot, V. & Schwaninger, M., 19.12.2022, In: BRAIN. 145, 12, p. 4264-4274 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4

    Tan, C., Lu, N-N., Wang, C-K., Chen, D-Y., Sun, N-H., Lyu, H., Körbelin, J., Shi, W-X., Fukunaga, K., Lu, Y-M. & Han, F., 06.03.2019, In: NEURON. 101, 5, p. 920-937.e13

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  42. Erratum for "Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors"

    Trepel, M., Körbelin, J., Spies, E., Heckmann, M. B., Hunger, A., Fehse, B., Katus, H. A., Kleinschmidt, J. A., Müller, O. J. & Michelfelder, S., 10.2015, In: GENE THER. 22, 10, p. 840-847

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  43. Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors

    Trepel, M., Körbelin, J., Spies, E., Heckmann, M. B., Hunger, A., Fehse, B., Katus, H. A., Kleinschmidt, J. A., Müller, O. J. & Michelfelder, S., 10.2015, In: GENE THER. 22, 10, p. 840-7 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. Neue Peptide mit Spezifität für die Lunge

    Trepel, M., Körbelin, J. & Michelfelder, S., 06.08.2014, IPC No. PCT/EP2014/066892, 12.02.2015, Priority date 09.08.2013, Priority No. DE201310215817

    Research output: Patent

  45. The Alzheimer's risk factor CD2AP drives defects across the cerebrovascular network

    Vandal, M., Gunn, C., Institoris, A., Bourassa, P., Korin, B., Lee, S., Mishra, R., Peringod, G., Hirai, S., Jiang, YL., Belzil, C., Reveret, L., Tremblay, C., Hashem, M., Nicola, W., Körbelin, J., Dunn, J., Braun, A., Bennett, D., Shaw, A., Gordon, G., Calon, FE. & Nguyen, MD., 19.06.2022, In: J CEREBR BLOOD F MET. 42, 1_SUPPL, p. 286-287 2 p.

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  46. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

    Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., Sauve, F., Coêlho, C. F. F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H. C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V. & Schwaninger, M., 11.2021, In: NAT NEUROSCI. 24, 11, p. 1522-1533 12 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  47. The SARS-CoV-2 main protease induces capillary cell death by cleaving NEMO in brain endothelial cells

    Wenzel, J., Lampe, J., Muller-Fielitz, H., Schuster, R., Zille, M., Körbelin, J., Sauve, F., Franz, J., Stadelmann, C., Trottein, F., Glatzel, M., Prevot, V. & Schwaninger, M., 19.06.2022, In: J CEREBR BLOOD F MET. 42, 1_SUPPL, p. 35 1 p.

    Research output: SCORING: Contribution to journalConference abstract in journalResearchpeer-review

  48. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

    Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., Nair, R. V., Bonanno, L. N., Yang, A. C., Peterson, T., Hadeiba, H., Merkel, T., Körbelin, J., Schwaninger, M., Buckwalter, M. S., Quake, S. R., Butcher, E. C. & Wyss-Coray, T., 06.2019, In: NAT MED. 25, 6, p. 988-1000 13 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review