Dr.med. ID: 50371
Ralf Oheim
Publications
- 2024
Patient experiences of interprofessional collaboration and intersectoral communication in rare disease healthcare in Germany - a mixed-methods study
Inhestern, L., Otto, R., Brandt, M., Zybarth, D., Oheim, R., Schüler, H., Mir, T. S., Tsiakas, K., Dibaj, P., Zschüntzsch, J., Okun, P. M., Hegenbart, U., Sommerburg, O., Schramm, C., Weiler-Normann, C., Härter, M. & Bergelt, C., 13.05.2024, In: ORPHANET J RARE DIS. 19, 1, p. 197Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hereditary hypophosphatemic rickets with hypercalciuria (HHRH), a complex disorder in need of precision medicine
Schinke, T. & Oheim, R., 05.2024, In: KIDNEY INT. 105, 5, p. 927-929 3 p.Research output: SCORING: Contribution to journal › Comment/debate › Research
Approaching virtual osteoid volume estimation and in-depth tissue characterization in patients with tumor-induced Osteomalacia
Schmidt, F. N., Delsmann, J., Yazigi, B., Beil, F. T., Amling, M. & Oheim, R., 22.03.2024, In: J BONE MINER RES. 39, 2, p. 116-129 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2023
Comparison of Motion Grading in 1,000 Patients by First- and Second-Generation HR-pQCT: A Propensity Score Matched Cohort Study
Bartosik, M., Simon, A., Strahl, A., Oheim, R., Amling, M. & Schmidt, F. N., 12.2023, In: CALCIFIED TISSUE INT. 113, 6, p. 597-608 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Epidemiology of Tumor-Induced Osteomalacia in Germany Based on Real World Data
May, M., Oheim, R., Bovy, L., Doess, A., Maessen, D., Neukirch, B., Norris, R., Williams, A. & Abrahamsen, B., 12.2023, In: CALCIFIED TISSUE INT. 113, 6, p. 630-639 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Empfehlungen zur Versorgung von Patient:innen mit FOP
Seefried, L., Banholzer, D., Fischer, R., Grafe, I., Hüning, I., Morhart, R., Oheim, R., Semler, O., Siggelkow, H., Stockklausner, C. & Hoyer-Kuhn, H., 11.2023, In: ORTHOPADIE. 52, 11, p. 924-930 7 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
AXIN1 bi-allelic variants disrupting the C-terminal DIX domain cause craniometadiaphyseal osteosclerosis with hip dysplasia
Terhal, P., Venhuizen, A. J., Lessel, D., Tan, W-H., Alswaid, A., Grün, R., Alzaidan, H. I., von Kroge, S., Ragab, N., Hempel, M., Kubisch, C., Novais, E., Cristobal, A., Tripolszki, K., Bauer, P., Fischer-Zirnsak, B., Nievelstein, R. A. J., van Dijk, A., Nikkels, P., Oheim, R., Hahn, H., Bertoli-Avella, A., Maurice, M. M. & Kornak, U., 07.09.2023, In: AM J HUM GENET. 110, 9, p. 1470-1481 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TMCO3, a Putative K+ :Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans
Holling, T., Brylka, L. J., Scholz, T., Bierhals, T., Herget, T., Meinecke, P., Schinke, T., Oheim, R. & Kutsche, K., 09.2023, In: J BONE MINER RES. 38, 9, p. 1334-1349 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dynamics of Skeletal Status under Optimized Management during Subsequent Pregnancy in Three Women with a History of Pregnancy- and Lactation-Associated Osteoporosis Carrying pathogenic Variants in WNT1 and LRP5
Stürznickel, J., Butscheidt, S., Amling, M. & Oheim, R., 08.2023, In: JBMR PLUS. 7, 8, e10779.Research output: SCORING: Contribution to journal › Case report › Research › peer-review
Bone mineral density and microarchitecture change during skeletal growth in harbor seals (Phoca vitulina) from the German coast
Delsmann, J., Schmidt, B., Oheim, R., Amling, M., Rolvien, T. & Siebert, U., 03.05.2023, In: SCI REP-UK. 13, 1, 7196.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study
Rupp, T., von Vopelius, E., Strahl, A., Oheim, R., Barvencik, F., Amling, M. & Rolvien, T., 10.2022, In: OSTEOPOROSIS INT. 33, 10, p. 2177-2184 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Catalysis-independent ENPP1 protein signaling regulates mammalian bone mass
Zimmerman, K., Li, X., von Kroge, S., Stabach, P., Lester, E. R., Chu, E. Y., Srivastava, S., Somerman, M. J., Tommasini, S. M., Busse, B., Schinke, T., Carpenter, T. O., Oheim, R. & Braddock, D. T., 09.2022, In: J BONE MINER RES. 37, 9, p. 1733-1749 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical spectrum of Hereditary Hypophosphatemic rickets with Hypercalciuria (HHRH)
Stürznickel, J., Heider, F., Delsmann, A., Gödel, M., Grünhagen, J., Huber, T. B., Kornak, U., Amling, M. & Oheim, R., 08.2022, In: J BONE MINER RES. 37, 8, p. 1580-1591 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Characterization of hearing-impairment in Generalized Arterial Calcification of Infancy (GACI)
Theng, E. H., Brewer, C. C., Oheim, R., Zalewski, C. K., King, K. A., Delsmann, M. M., Rolvien, T., Gafni, R. I., Braddock, D. T., Jeffrey Kim, H. & Ferreira, C. R., 19.07.2022, In: ORPHANET J RARE DIS. 17, 1, 273.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic Diagnostics in Routine Osteological Assessment of Adult Low Bone Mass Disorders
Oheim, R., Tsourdi, E., Seefried, L., Beller, G., Schubach, M., Vettorazzi, E., Stürznickel, J., Rolvien, T., Ehmke, N., Delsmann, A., Genest, F., Krüger, U., Zemojtel, T., Barvencik, F., Schinke, T., Jakob, F., Hofbauer, L. C., Mundlos, S. & Kornak, U., 16.06.2022, In: J CLIN ENDOCR METAB. 107, 7, p. e3048-e3057Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Tumorlokalisation und Therapie der onkogenen Osteomalazie
Beil, F. T., Stürznickel, J., Rolvien, T., Amling, M. & Oheim, R., 04.2022, In: Z RHEUMATOL. 81, 3, p. 182-188 7 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Blast injury on harbour porpoises (Phocoena phocoena) from the Baltic Sea after explosions of deposits of World War II ammunition
Siebert, U., Stürznickel, J., Schaffeld, T., Oheim, R., Rolvien, T., Prenger-Berninghoff, E., Wohlsein, P., Lakemeyer, J., Rohner, S., Aroha Schick, L., Gross, S., Nachtsheim, D., Ewers, C., Becher, P., Amling, M. & Morell, M., 15.01.2022, In: ENVIRON INT. 159, 107014.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Autosomal recessive hypophosphatemic rickets type 2 (ARHR2) due to ENPP1-deficiency
Höppner, J., Kornak, U., Sinningen, K., Rutsch, F., Oheim, R. & Grasemann, C., 12.2021, In: BONE. 153, 116111.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Conductive hearing loss in the Hyp mouse model of X-linked hypophosphatemia is accompanied by hypomineralization of the auditory ossicles
Delsmann, M. M., Seist, R., Stürznickel, J., Schmidt, F. N., Mansour, A., Kobelski, M. M., Broocks, G., Peichl, J., Oheim, R., Praetorius, M., Schinke, T., Amling, M., Demay, M. B., Stankovic, K. M. & Rolvien, T., 12.2021, In: J BONE MINER RES. 36, 12, p. 2317-2328 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The WNT1G177C mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV
Vollersen, N., Zhao, W., Rolvien, T., Lange, F., Schmidt, F. N., Sonntag, S., Shmerling, D., von Kroge, S., Stockhausen, K. E., Sharaf, A., Schweizer, M., Karsak, M., Busse, B., Bockamp, E., Semler, O., Amling, M., Oheim, R., Schinke, T. & Yorgan, T. A., 10.11.2021, In: BONE RES. 9, 1, p. 48Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Challenges in the management of tumor-induced osteomalacia (TIO)
Brandi, M. L., Clunie, G. P. R., Houillier, P., Jan de Beur, S. M., Minisola, S., Oheim, R. & Seefried, L., 11.2021, In: BONE. 152, p. 116064Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Skeletal characterization in a patient with Hajdu-Cheney syndrome undergoing total knee arthroplasty
von Vopelius, E., Oheim, R., Amling, M., Rolvien, T. & Beil, F. T., 09.2021, In: OSTEOPOROSIS INT. 32, 9, p. 1899-1904 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Bone microarchitecture in patients with autoimmune hepatitis
Schmidt, C., Stürznickel, J., Strahl, A., Oheim, R., Weiler-Normann, C., Sebode, M., Barvencik, F., Lohse, A. W., Schinke, T., Amling, M., Schramm, C. & Rolvien, T., 07.2021, In: J BONE MINER RES. 36, 7, p. 1316-1325 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Compound heterozygous frameshift mutations in MESD cause a lethal syndrome suggestive of osteogenesis imperfecta type XX
Stürznickel, J., Jähn-Rickert, K., Zustin, J., Hennig, F., Delsmann, M. M., Schoner, K., Rehder, H., Kreczy, A., Schinke, T., Amling, M., Kornak, U. & Oheim, R., 06.2021, In: J BONE MINER RES. 36, 6, p. 1077-1087 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Relevant genetic variants are common in women with pregnancy and lactation-associated osteoporosis (PLO) and predispose to more severe clinical manifestations
Butscheidt, S. K., Tsourdi, E., Rolvien, T., Delsmann, A., Stürznickel, J., Barvencik, F., Jakob, F., Hofbauer, L. C., Mundlos, S., Kornak, U., Seefried, L. & Oheim, R., 06.2021, In: BONE. 147, 115911.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison of hamstring and quadriceps tendon autografts in anterior cruciate ligament reconstruction with gait analysis and surface electromyography
Schagemann, J., Koebrich, T., Wendlandt, R., Schulz, A. P., Gille, J. & Oheim, R., 21.05.2021, In: J ORTHOP TRAUMATOL. 22, 1, 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Bilateral Looser zones or pseudofractures in the anteromedial tibia as a component of medial tibial stress syndrome in athletes
Stürznickel, J., Jandl, N. M., Delsmann, M. M., von Vopelius, E., Barvencik, F., Amling, M., Ueblacker, P., Rolvien, T. & Oheim, R., 05.2021, In: KNEE SURG SPORT TR A. 29, 5, p. 1644-1650 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Response of the ENPP1-deficient skeletal phenotype to oral phosphate supplementation and/or enzyme replacement therapy: Comparative studies in Humans and Mice
Ferreira, C. R., Kavanagh, D., Oheim, R., Zimmerman, K., Stürznickel, J., Li, X., Stabach, P., Rettig, R. L., Calderone, L., MacKichan, C., Wang, A., Hutchinson, H. A., Nelson, T., Tommassini, S. M., von Kroge, S., Fiedler, I. A. K., Lester, E. R., Moeckel, G. W., Busse, B., Schinke, T., Carpenter, T. O., Levine, M. A., Horwowitz, M. C. & Braddock, D. T., 05.2021, In: J BONE MINER RES. 36, 5, p. 942-955 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Bone healing and reactivation of remodeling under asfotase alfa therapy in adult patients with pediatric-onset hypophosphatasia
Stürznickel, J., Schmidt, F. N., von Vopelius, E., Delsmann, M. M., Schmidt, C., Jandl, N. M., Oheim, R. & Barvencik, F., 02.2021, In: BONE. 143, p. 115794Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical and Radiological Characterization of Patients with Immobilizing and Progressive Stress Fractures in Methotrexate Osteopathy
Rolvien, T., Jandl, N. M., Stürznickel, J., Beil, F. T., Kötter, I., Oheim, R., Lohse, A. W., Barvencik, F. & Amling, M., 02.2021, In: CALCIFIED TISSUE INT. 108, 2, p. 219-230 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP)
Stürznickel, J., Rolvien, T., Delsmann, A., Butscheidt, S., Barvencik, F., Mundlos, S., Schinke, T., Kornak, U., Amling, M. & Oheim, R., 02.2021, In: J BONE MINER RES. 36, 2, p. 271-282 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Variation in skull bone mineral density of ringed seals (Phoca hispida) from the Gulf of Bothnia and West Greenland between 1829 and 2019
Schmidt, B., Sonne, C., Nachtsheim, D., Dietz, R., Oheim, R., Rolvien, T., Persson, S., Amling, M. & Siebert, U., 10.2020, In: ENVIRON INT. 143, p. 105968Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone-specific phenotype
Yorgan, T., Rolvien, T., Stürznickel, J., Vollersen, N., Lange, F., Zhao, W., Baranowsky, A., Rosenthal, L., Hermans-Borgmeyer, I., Sharaf, A., Karsak, M., David, J-P., Oheim, R., Amling, M. & Schinke, T., 09.2020, In: J BONE MINER RES. 35, 9, p. 1726-1737 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Whole-Exome Sequencing Identifies Novel Compound Heterozygous ZNF469 Mutations in Two Siblings with Mild Brittle Cornea Syndrome
Rolvien, T., Kornak, U., Linke, S. J., Amling, M. & Oheim, R., 09.2020, In: CALCIFIED TISSUE INT. 107, 3, p. 294-299 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Adult osteosclerotic metaphyseal dysplasia with progressive osteonecrosis of the jaws and abnormal bone resorption pattern due to a LRRK1 splice site mutation
Howaldt, A., Hennig, A. F., Rolvien, T., Rössler, U., Stelzer, N., Knaus, A., Böttger, S., Zustin, J., Geißler, S., Oheim, R., Amling, M., Howaldt, H-P. & Kornak, U., 07.2020, In: J BONE MINER RES. 35, 7, p. 1322-1332 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gnathodiaphyseal dysplasia is not recapitulated in a respective mouse model carrying a mutation of the Ano5 gene
Rolvien, T., Avci, O., von Kroge, S., Koehne, T., Selbert, S., Sonntag, S., Shmerling, D., Kornak, U., Oheim, R., Amling, M., Schinke, T. & Yorgan, T. A., 06.2020, In: BONE REP. 12, p. 100281Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired Bone Microarchitecture in Patients with Hereditary Hemochromatosis and Skeletal Complications
Jandl, N. M., Rolvien, T., Schmidt, T., Mussawy, H., Nielsen, P., Oheim, R., Amling, M. & Barvencik, F., 05.2020, In: CALCIFIED TISSUE INT. 106, 5, p. 465-475 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency
Oheim, R., Zimmerman, K., Maulding, N. D., Stürznickel, J., von Kroge, S., Kavanagh, D., Stabach, P. R., Kornak, U., Tommasini, S. M., Horowitz, M. C., Amling, M., Thompson, D., Schinke, T., Busse, B., Carpenter, T. O. & Braddock, D. T., 03.2020, In: J BONE MINER RES. 35, 3, p. 528-539 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis
Rolvien, T., Yorgan, T. A., Kornak, U., Hermans-Borgmeyer, I., Mundlos, S., Schmidt, T., Niemeier, A., Schinke, T., Amling, M. & Oheim, R., 03.2020, In: OSTEOARTHR CARTILAGE. 28, 3, p. 334-343 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A System to Determine Risk of Osteoporosis in Patients With Autoimmune Hepatitis
Schmidt, T., Schmidt, C., Strahl, A., Mussawy, H., Rolvien, T., Jandl, N. M., Casar, C., Oheim, R., Schinke, T., Lohse, A. W., Amling, M., Schramm, C. & Barvencik, F., 01.2020, In: CLIN GASTROENTEROL H. 18, 1, p. 226-233.e3Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mice lacking plastin-3 display a specific defect of cortical bone acquisition
Yorgan, T., Sari, H., Rolvien, T., Windhorst, S., Failla, A. V., Kornak, U., Oheim, R., Amling, M. & Schinke, T., 01.2020, In: BONE. 130, p. 115062Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Intra-articular osteoid osteoma accompanied by extensive bone marrow edema. A clinical and micro-morphological analysis
Rolvien, T., Krause, M., Zustin, J., Yastrebov, O., Oheim, R., Barvencik, F., Frosch, K-H. & Amling, M., 10.2019, In: J BONE ONCOL. 18, p. 100256Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High FGF23 levels are associated with impaired trabecular bone microarchitecture in patients with osteoporosis
Rupp, T., Butscheidt, S., Vettorazzi, E., Oheim, R., Barvencik, F., Amling, M. & Rolvien, T., 08.2019, In: OSTEOPOROSIS INT. 30, 8, p. 1655-1662 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Outcome of Teriparatide Treatment on Fracture Healing Complications and Symptomatic Bone Marrow Edema in Four Adult Patients With Hypophosphatasia
Schmidt, T., Rolvien, T., Linke, C., Jandl, N. M., Oheim, R., Amling, M. & Barvencik, F., 08.2019, In: JBMR PLUS. 3, 8, p. e10215Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Bone microstructure is significantly altered in CRPS-affected distal tibiae as detected by HR-pQCT: a retrospective cross-sectional study
Oehler, N., Rolvien, T., Schmidt, T., Butscheidt, S., Oheim, R., Barvencik, F. & Mussawy, H., 07.2019, In: J BONE MINER METAB. 37, 4, p. 741-748 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Th17 cell frequency is associated with low bone mass in primary sclerosing cholangitis
Schmidt, T., Schwinge, D., Rolvien, T., Jeschke, A., Schmidt, C., Neven, M., Butscheidt, S., Kriz, M., Kunzmann, L., Mussawy, H., Hubert, J., Hawellek, T., Rüther, W., Oheim, R., Barvencik, F., Lohse, A. W., Schramm, C., Schinke, T. & Amling, M., 05.2019, In: J HEPATOL. 70, 5, p. 941-953 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A novel FAM20C mutation causing hypophosphatemic osteomalacia with osteosclerosis (mild Raine syndrome) in an elderly man with spontaneous osteonecrosis of the knee
Rolvien, T., Kornak, U., Schinke, T., Amling, M. & Oheim, R., 03.2019, In: OSTEOPOROSIS INT. 30, 3, p. 685-689 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Ultra-high matrix mineralization of sperm whale auditory ossicles facilitates high sound pressure and high-frequency underwater hearing
Schmidt, F. N., Delsmann, M. M., Mletzko, K., Yorgan, T. A., Hahn, M., Siebert, U., Busse, B., Oheim, R., Amling, M. & Rolvien, T., 19.12.2018, In: P ROY SOC B-BIOL SCI. 285, 1893, p. 20181820 1 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand
Luther, J., Yorgan, T. A., Rolvien, T., Ulsamer, L., Koehne, T., Liao, N., Keller, D., Vollersen, N., Teufel, S., Neven, M., Peters, S., Schweizer, M., Trumpp, A., Rosigkeit, S., Bockamp, E., Mundlos, S., Kornak, U., Oheim, R., Amling, M., Schinke, T. & David, J-P., 07.11.2018, In: SCI TRANSL MED. 10, 466, p. eaau7137Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison of Bone Microarchitecture Between Adult Osteogenesis Imperfecta and Early-Onset Osteoporosis
Rolvien, T., Stürznickel, J., Schmidt, F. N., Butscheidt, S., Schmidt, T., Busse, B., Mundlos, S., Schinke, T., Kornak, U., Amling, M. & Oheim, R., 11.2018, In: CALCIFIED TISSUE INT. 103, 5, p. 512-521 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review