Markus Rinschen
Publications
- 2024
Autoantibodies Targeting Nephrin in Podocytopathies
Hengel, F. E., Dehde, S., Lassé, M., Zahner, G., Seifert, L., Schnarre, A., Kretz, O., Demir, F., Pinnschmidt, H. O., Grahammer, F., Lucas, R., Mehner, L. M., Zimmermann, T., Billing, A. M., Oh, J., Mitrotti, A., Pontrelli, P., Debiec, H., Dossier, C., Colucci, M., Emma, F., Smoyer, W. E., Weins, A., Schaefer, F., Alachkar, N., Diemert, A., Hogan, J., Hoxha, E., Wiech, T., Rinschen, M. M., Ronco, P., Vivarelli, M., Gesualdo, L., Tomas, N. M., Huber, T. B. & International Society of Glomerular Disease, 01.08.2024, In: NEW ENGL J MED. 391, 5, p. 422-433 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Kurmasheva, N., Said, A., Wong, B., Kinderman, P., Han, X., Rahimic, A. H. F., Kress, A., Carter-Timofte, M. E., Holm, E., van der Horst, D., Kollmann, C. F., Liu, Z., Wang, C., Hoang, H-D., Kovalenko, E., Chrysopoulou, M., Twayana, K. S., Ottosen, R. N., Svenningsen, E. B., Begnini, F., Kiib, A. E., Kromm, F. E. H., Weiss, H. J., Di Carlo, D., Muscolini, M., Higgins, M., van der Heijden, M., Bardoul, A., Tong, T., Ozsvar, A., Hou, W-H., Schack, V. R., Holm, C. K., Zheng, Y., Ruzek, M., Kalucka, J., de la Vega, L., Elgaher, W. A. M., Korshoej, A. R., Lin, R., Hiscott, J., Poulsen, T. B., O'Neill, L. A., Roy, D. G., Rinschen, M. M., van Montfoort, N., Diallo, J-S., Farin, H. F., Alain, T. & Olagnier, D., 15.05.2024, In: NAT COMMUN. 15, 1, p. 4096Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney
Gyarmati, G., Shroff, U. N., Riquier-Brison, A., Desposito, D., Ju, W., Stocker, S. D., Izuhara, A., Deepak, S., Becerra Calderon, A., Burford, J. L., Kadoya, H., Moon, J-Y., Chen, Y., Rinschen, M. M., Ahmadi, N., Lau, L., Biemesderfer, D., James, A. W., Minichiello, L., Zlokovic, B. V., Gill, I. S., Kretzler, M. & Peti-Peterdi, J., 10.04.2024, In: J CLIN INVEST. 134, 11, e174558.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration
Sachs, W., Blume, L., Loreth, D., Schebsdat, L., Hatje, F., Koehler, S., Wedekind, U., Sachs, M., Zieliniski, S., Brand, J., Conze, C., Florea, B. I., Heppner, F., Krüger, E., Rinschen, M. M., Kretz, O., Thünauer, R. & Meyer-Schwesinger, C., 01.03.2024, In: NAT COMMUN. 15, 1, p. 1897Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function
Chrysopoulou, M. & Rinschen, M. M., 12.02.2024, In: ANNU REV PHYSIOL. 86, p. 405-427 23 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
High Salt Remodels Kidney Metabolism: Metabolite Fuel, Fate, and Signals
Lassé, M. & Rinschen, M. M., 2024, In: FUNCTION. 5, 2, zqae006.Research output: SCORING: Contribution to journal › Comment/debate › Research
- 2023
In vivo characterization of a podocyte-expressed short podocin isoform
Butt, L., Unnersjö-Jess, D., Reilly, D., Hahnfeldt, R., Rinschen, M. M., Bozek, K., Schermer, B., Benzing, T. & Höhne, M., 19.12.2023, In: BMC NEPHROL. 24, 1, 378.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Integrative physiology of lysine metabolites
Tan, Y., Chrysopoulou, M. & Rinschen, M. M., 01.12.2023, In: PHYSIOL GENOMICS. 55, 12, p. 579-586 8 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
Navigating the Omics Frontier: Challenges, Opportunities, and the Future of Precision Nephrology
Rinschen, M. M. & Knepper, M. A., 01.12.2023, In: J AM SOC NEPHROL. 34, 12, p. 1943-1944 2 p.Research output: SCORING: Contribution to journal › Editorial › Research
Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux
Spangenberg, S. H., Palermo, A., Gazaniga, N. R., Martínez-Peña, F., Guijas, C., Chin, E. N., Rinschen, M. M., Sander, P. N., Webb, B., Pereira, L. E., Jia, Y., Meitz, L., Siuzdak, G. & Lairson, L. L., 21.09.2023, In: CELL CHEM BIOL. 30, 9, p. 1115-1134.e10Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Long-read sequencing identifies a common transposition haplotype predisposing for CLCNKB deletions
Tschernoster, N., Erger, F., Kohl, S., Reusch, B., Wenzel, A., Walsh, S., Thiele, H., Becker, C., Franitza, M., Bartram, M. P., Kömhoff, M., Schumacher, L., Kukat, C., Borodina, T., Quedenau, C., Nürnberg, P., Rinschen, M. M., Driller, J. H., Pedersen, B. P., Schlingmann, K. P., Hüttel, B., Bockenhauer, D., Beck, B. & Altmüller, J., 23.08.2023, In: GENOME MED. 15, 1, 62.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
An integrated organoid omics map extends modeling potential of kidney disease
Lassé, M., El Saghir, J., Berthier, C. C., Eddy, S., Fischer, M., Laufer, S. D., Kylies, D., Hutzfeldt, A., Bonin, L. L., Dumoulin, B., Menon, R., Vega-Warner, V., Eichinger, F., Alakwaa, F., Fermin, D., Billing, A. M., Minakawa, A., McCown, P. J., Rose, M. P., Godfrey, B., Meister, E., Wiech, T., Noriega, M., Chrysopoulou, M., Brandts, P., Ju, W., Reinhard, L., Hoxha, E., Grahammer, F., Lindenmeyer, M. T., Huber, T. B., Schlüter, H., Thiel, S., Mariani, L. H., Puelles, V. G., Braun, F., Kretzler, M., Demir, F., Harder, J. L. & Rinschen, M. M., 14.08.2023, In: NAT COMMUN. 14, 1, 4903.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
Braun, F., Abed, A., Sellung, D., Rogg, M., Woidy, M., Eikrem, O., Wanner, N., Gambardella, J., Laufer, S. D., Haas, F., Wong, M. N., Dumoulin, B., Rischke, P., Mühlig, A. K., Sachs, W., von Cossel, K., Schulz, K., Muschol, N., Gersting, S. W., Muntau, A. C., Kretz, O., Hahn, O., Rinschen, M. M., Mauer, M., Bork, T., Grahammer, F., Liang, W., Eierhoff, T., Römer, W., Hansen, A., Meyer-Schwesinger, C., Iaccarino, G., Tøndel, C., Marti, H-P., Najafian, B., Puelles, V. G., Schell, C. & Huber, T. B., 01.06.2023, In: J CLIN INVEST. 133, 11, e157782.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pathogenicity of Human anti-PLA2R1 Antibodies in Minipigs: A Pilot Study
Reinhard, L., Wiech, T., Reitmeier, A., Lassé, M., Machalitza, M., Heumann, A., Ferru, N., Loreth, D., Schröder, M-L., Hutzfeldt, A., Stahl, F. R., Peine, S., Gröne, H-J., Meyer-Schwesinger, C., Rinschen, M. M., Stahl, R. A. K. & Hoxha, E., 01.03.2023, In: J AM SOC NEPHROL. 34, 3, p. 369-373 5 p.Research output: SCORING: Contribution to journal › Letter › Research › peer-review
Modeling of ACTN4-Based Podocytopathy Using Drosophila Nephrocytes
Odenthal, J., Dittrich, S., Ludwig, V., Merz, T., Reitmeier, K., Reusch, B., Höhne, M., Cosgun, Z. C., Hohenadel, M., Putnik, J., Göbel, H., Rinschen, M. M., Altmüller, J., Koehler, S., Schermer, B., Benzing, T., Beck, B. B., Brinkkötter, P. T., Habbig, S. & Bartram, M. P., 02.2023, In: KIDNEY INT REP. 8, 2, p. 317-329 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Primary Focal Segmental Glomerulosclerosis Plasmas Increase Lipid Droplet Formation and Perilipin-2 Expression in Human Podocytes
den Braanker, D. J. W., Maas, R. J. H., van Mierlo, G., Parr, N. M. J., Bakker-van Bebber, M., Deegens, J. K. J., Jansen, P. W. T. C., Gloerich, J., Willemsen, B., Dijkman, H. B., van Gool, A. J., Wetzels, J. F. M., Rinschen, M. M., Vermeulen, M., Nijenhuis, T. & van der Vlag, J., 22.12.2022, In: INT J MOL SCI. 24, 1, 194.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney
Rinschen, M. M., Harder, J. L., Carter-Timofte, M. E., Zanon Rodriguez, L., Mirabelli, C., Demir, F., Kurmasheva, N., Ramakrishnan, S. K., Kunke, M., Tan, Y., Billing, A., Dahlke, E., Larionov, A. A., Bechtel-Walz, W., Aukschun, U., Grabbe, M., Nielsen, R., Christensen, E. I., Kretzler, M., Huber, T. B., Wobus, C. E., Olagnier, D., Siuzdak, G., Grahammer, F. & Theilig, F., 29.11.2022, In: SCIENCE SIGNALING. 15, 762, p. eabo7940Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Netrin G1 is a Novel Target Antigen in Primary Membranous Nephropathy
Reinhard, L., Machalitza, M., Wiech, T., Groene, H-J., Lassé, M., Rinschen, M., Ferru, N., Bräsen, J., Drömann, F., Rob, P., Sethi, S., Hoxha, E. & Stahl, R., 10.2022, In: J AM SOC NEPHROL. 33, 10, p. 1823-1831 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Consensus draft of the native mouse podocyte-ome
Hutzfeldt, A., Tan, Y., Bonin, L. L., Beck, B. B., Baumbach, J., Lassé, M., Demir, F. & Rinschen, M., 01.08.2022, In: AM J PHYSIOL-RENAL. 323, 2, p. F182-F197Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression
Akbari, M., West, J. D., Doerr, N., Kipp, K. R., Marhamati, N., Vuong, S., Wang, Y., Rinschen, M. M., Talbot, J. J., Wessely, O. & Weimbs, T., 26.07.2022, In: P NATL ACAD SCI USA. 119, 30, e2121267119.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
Rinschen, M. M., Palygin, O., El-Meanawy, A., Domingo-Almenara, X., Palermo, A., Dissanayake, L. V., Golosova, D., Schafroth, M. A., Guijas, C., Demir, F., Jaegers, J., Gliozzi, M. L., Xue, J., Hoehne, M., Benzing, T., Kok, B. P., Saez, E., Bleich, M., Himmerkus, N., Weisz, O. A., Cravatt, B. F., Krüger, M., Benton, H. P., Siuzdak, G. & Staruschenko, A., 14.07.2022, In: NAT COMMUN. 13, 1, 4099.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Calcium-Sensing Receptor Stabilizes Podocyte Function in Proteinuric Humans and Mice
Mühlig, A. K., Steingröver, J., Heidelbach, H. S., Wingerath, M., Sachs, W., Hermans-Borgmeyer, I., Meyer-Schwesinger, C., Choi, H. Y., Lim, B. J., Patry, C., Hoffmann, G. F., Endlich, N., Bracke, K., Weiß, M., Guse, A. H., Lassé, M., Rinschen, M., Braun, F., Huber, T. B., Puelles, V. G., Schmitt, C. P. & Oh, J., 06.2022, In: KIDNEY INT. 101, 6, p. 1186-1199 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells
Reusch, B., Bartram, M. P., Dafinger, C., Palacio-Escat, N., Wenzel, A., Fenton, R. A., Saez-Rodriguez, J., Schermer, B., Benzing, T., Altmüller, J., Beck, B. B. & Rinschen, M. M., 10.02.2022, In: J PROTEOMICS. 252, 104424.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
Butt, L., Unnersjö-Jess, D., Höhne, M., Hahnfeldt, R., Reilly, D., Rinschen, M., Plagmann, I., Diefenhardt, P., Braehler, S., Brinkkötter, P., Brismar, H., Blom, H., Schermer, B. & Benzing, T., 01.2022, In: J AM SOC NEPHROL. 33, 1, p. 138-154 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis
Banki, E., Fisi, V., Moser, S., Wengi, A., Carrel, M., Loffing-Cueni, D., Penton, D., Kratschmar, D. V., Rizzo, L., Lienkamp, S., Odermatt, A., Rinschen, M. M. & Loffing, J., 10.2021, In: KIDNEY INT. 100, 4, p. 850-869 20 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Tripartite Separation of Glomerular Cell-Types and Proteomes From Reporter-Free Mice
Hatje, F., Wedekind, U., Sachs, W., Loreth, D., Reichelt, J., Demir, F., Kosub, C., Heintz, L., Tomas, N., Huber, T., Skuza, S., Sachs, M., Zielinski, S., Rinschen, M. & Meyer-Schwesinger, C., 09.2021, In: J AM SOC NEPHROL. 32, 9, p. 2175-2193 19 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Maintaining proteostasis under mechanical stress
Höhfeld, J., Benzing, T., Bloch, W., Fürst, D. O., Gehlert, S., Hesse, M., Hoffmann, B., Hoppe, T., Huesgen, P. F., Köhn, M., Kolanus, W., Merkel, R., Niessen, C. M., Pokrzywa, W., Rinschen, M. M., Wachten, D. & Warscheid, B., 04.08.2021, In: EMBO REP. 22, 8, e52507.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Proteolysis and inflammation of the kidney glomerulus
Demir, F., Troldborg, A., Thiel, S., Lassé, M., Huesgen, P. F., Tomas, N. M., Wiech, T. & Rinschen, M. M., 08.2021, In: CELL TISSUE RES. 385, 2, p. 489-500 12 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
A stressed barrier left behind: stochastic podocyte ablation triggers secondary injury
Koehler, S. & Rinschen, M. M., 01.05.2021, In: AM J PHYSIOL-RENAL. 320, 5, p. F866-F869Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
MANTI: Automated Annotation of Protein N-Termini for Rapid Interpretation of N-Terminome Data Sets
Demir, F., Kizhakkedathu, J. N., Rinschen, M. M. & Huesgen, P. F., 06.04.2021, In: ANAL CHEM. 93, 13, p. 5596-5605 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cognitive analysis of metabolomics data for systems biology
Majumder, E. L-W., Billings, E. M., Benton, H. P., Martin, R. L., Palermo, A., Guijas, C., Rinschen, M. M., Domingo-Almenara, X., Montenegro-Burke, J. R., Tagtow, B. A., Plumb, R. S. & Siuzdak, G., 03.2021, In: NAT PROTOC. 16, 3, p. 1376-1418 43 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The tissue proteome in the multi-omic landscape of kidney disease
Rinschen, M. M. & Saez-Rodriguez, J., 03.2021, In: NAT REV NEPHROL. 17, 3, p. 205-219 15 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
- 2020
The proteomic landscape of small urinary extracellular vesicles during kidney transplantation
Braun, F., Rinschen, M., Buchner, D., Bohl, K., Plagmann, I., Bachurski, D., Richard Späth, M., Antczak, P., Göbel, H., Klein, C., Lackmann, J-W., Kretz, O., Puelles, V. G., Wahba, R., Hallek, M., Schermer, B., Benzing, T., Huber, T. B., Beyer, A., Stippel, D., Kurschat, C. E. & Müller, R-U., 10.2020, In: J EXTRACELL VESICLES. 10, 1, p. e12026Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells
Fatima, A., Irmak, D., Noormohammadi, A., Rinschen, M. M., Das, A., Leidecker, O., Schindler, C., Sánchez-Gaya, V., Wagle, P., Pokrzywa, W., Hoppe, T., Rada-Iglesias, A. & Vilchez, D., 25.05.2020, In: COMMUN BIOL. 3, 1, p. 262Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A molecular mechanism explaining albuminuria in kidney disease
Butt, L., Unnersjö-Jess, D., Höhne, M., Edwards, A., Binz-Lotter, J., Reilly, D., Hahnfeldt, R., Ziegler, V., Fremter, K., Rinschen, M. M., Helmstädter, M., Ebert, L. K., Castrop, H., Hackl, M. J., Walz, G., Brinkkoetter, P. T., Liebau, M. C., Tory, K., Hoyer, P. F., Beck, B. B., Brismar, H., Blom, H., Schermer, B. & Benzing, T., 05.2020, In: NAT METAB. 2, 5, p. 461-474 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PKA-independent vasopressin signaling in renal collecting duct
Datta, A., Yang, C-R., Limbutara, K., Chou, C-L., Rinschen, M. M., Raghuram, V. & Knepper, M. A., 05.2020, In: FASEB J. 34, 5, p. 6129-6146 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Enhanced in-Source Fragmentation Annotation Enables Novel Data Independent Acquisition and Autonomous METLIN Molecular Identification
Xue, J., Domingo-Almenara, X., Guijas, C., Palermo, A., Rinschen, M. M., Isbell, J., Benton, H. P. & Siuzdak, G., 21.04.2020, In: ANAL CHEM. 92, 8, p. 6051-6059 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling
Binz-Lotter, J., Jüngst, C., Rinschen, M. M., Koehler, S., Zentis, P., Schauss, A., Schermer, B., Benzing, T. & Hackl, M. J., 03.2020, In: J AM SOC NEPHROL. 31, 3, p. 532-542 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Metabolic rewiring of the hypertensive kidney
Rinschen, M. M., Palygin, O., Guijas, C., Palermo, A., Palacio-Escat, N., Domingo-Almenara, X., Montenegro-Burke, R., Saez-Rodriguez, J., Staruschenko, A. & Siuzdak, G., 10.12.2019, In: SCIENCE SIGNALING. 12, 611Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Protein half-life determines expression of proteostatic networks in podocyte differentiation
Schroeter, C. B., Koehler, S., Kann, M., Schermer, B., Benzing, T., Brinkkoetter, P. T. & Rinschen, M. M., 09.2018, In: FASEB J. 32, 9, p. 4696-4713 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Quantitative deep mapping of the cultured podocyte proteome uncovers shifts in proteostatic mechanisms during differentiation
Rinschen, M. M., Schroeter, C. B., Koehler, S., Ising, C., Schermer, B., Kann, M., Benzing, T. & Brinkkoetter, P. T., 01.09.2016, In: AM J PHYSIOL-CELL PH. 311, 3, p. C404-17Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review