Research ExplorerScientific StaffAymelt Itzen Publications

Prof. Dr. ID: 5920599

Aymelt Itzen

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Affiliations
ORCID: 0000-0002-4249-5617
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Publications

  1. 2024

  2. Pronucleotide Probes Reveal a Diverging Specificity for AMPylation vs UMPylation of Human and Bacterial Nucleotide Transferases

    Mostert, D., Bubeneck, W. A., Rauh, T., Kielkowski, P., Itzen, A., Jung, K. & Sieber, S. A., 05.03.2024, In: BIOCHEMISTRY-US. 63, 5, p. 651-659 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. 2023

  4. The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3

    Höpfner, D., Cichy, A., Pogenberg, V., Krisp, C., Mezouar, S., Bach, N. C., Grotheer, J., Zarza, S. M., Martinez, E., Bonazzi, M., Feige, M. J., Sieber, S. A., Schlüter, H. & Itzen, A., 06.11.2023, In: COMMUN BIOL. 6, 1, p. 1124

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b

    Kaspers, M. S., Pogenberg, V., Pett, C., Ernst, S., Ecker, F., Ochtrop, P., Groll, M., Hedberg, C. & Itzen, A., 19.04.2023, In: NAT COMMUN. 14, 1, p. 2245

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. The Alarmone Diadenosine Tetraphosphate as a Cosubstrate for Protein AMPylation

    Frese, M., Saumer, P., Yuan, Y., Herzog, D., Höpfner, D., Itzen, A. & Marx, A., 13.02.2023, In: ANGEW CHEM INT EDIT. 62, 8, p. e202213279 e202213279.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. 2022

  8. Revisiting AMPylation through the lens of Fic enzymes

    Gulen, B. & Itzen, A., 04.2022, In: TRENDS MICROBIOL. 30, 4, p. 350-363 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  9. 2021

  10. SopD from Salmonella specifically inactivates Rab8

    Savitskiy, S. & Itzen, A., 08.2021, In: BBA-PROTEINS PROTEOM. 1869, 8, p. 140661

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Erratum: Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation

    Höpfner, D., Fauser, J., Kaspers, M. S., Pett, C., Hedberg, C. & Itzen, A., 23.07.2021, In: ISCIENCE. 24, 7, p. 102731

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  12. Current Advances in Covalent Stabilization of Macromolecular Complexes for Structural Biology

    Fauser, J., Itzen, A. & Gulen, B., 19.05.2021, In: BIOCONJUGATE CHEM. 32, 5, p. 879-890 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  13. Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

    Fauser, J., Gulen, B., Pogenberg, V., Pett, C., Pourjafar-Dehkordi, D., Krisp, C., Höpfner, D., König, G., Schlüter, H., Feige, M. J., Zacharias, M., Hedberg, C. & Itzen, A., 23.04.2021, In: NAT COMMUN. 12, 1, 2426.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation

    Savitskiy, S., Wachtel, R., Pourjafar-Dehkordi, D., Kang, H-S., Trauschke, V., Lamb, D. C., Sattler, M., Zacharias, M. & Itzen, A., 22.01.2021, In: ISCIENCE. 24, 1, 101940.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1

    Du, J., Wrisberg, M-K. V., Gulen, B., Stahl, M., Pett, C., Hedberg, C., Lang, K., Schneider, S. & Itzen, A., 19.01.2021, In: NAT COMMUN. 12, 1, 460.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. 2020

  17. Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation

    Höpfner, D., Fauser, J., Kaspers, M. S., Pett, C., Hedberg, C. & Itzen, A., 18.12.2020, In: ISCIENCE. 23, 12, 101800.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture

    Gulen, B., Rosselin, M., Fauser, J., Albers, M. F., Pett, C., Krisp, C., Pogenberg, V., Schlüter, H., Hedberg, C. & Itzen, A., 08.2020, In: NAT CHEM. 12, 8, p. 732-739 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

    Daub, H., Traxler, L., Ismajli, F., Groitl, B., Itzen, A. & Rant, U., 09.06.2020, In: SCI REP-UK. 10, 1, p. 9265

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

    Vieweg, S., Mulholland, K., Brauning, B., Kacharia, N., Lai, Y-C., Toth, R., Singh, P. K., Volpi, I., Sattler, M., Groll, M., Itzen, A. & Muqit, M. M. K., 15.05.2020, In: BIOCHEM J. 477, 9, p. 1651-1668 18 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination

    Ernst, S., Ecker, F., Kaspers, M. S., Ochtrop, P., Hedberg, C., Groll, M. & Itzen, A., 05.2020, In: SCI ADV. 6, 20, p. eaaz8041

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

    Schiedel, M., Daub, H., Itzen, A. & Jung, M., 17.04.2020, In: CHEMBIOCHEM. 21, 8, p. 1161-1166 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets

    Swart, A. L., Steiner, B., Gomez-Valero, L., Schütz, S., Hannemann, M., Janning, P., Irminger, M., Rothmeier, E., Buchrieser, C., Itzen, A., Panse, V. G. & Hilbi, H., 24.03.2020, In: MBIO. 11, 2

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Conformational control of small GTPases by AMPylation

    Barthelmes, K., Ramcke, E., Kang, H-S., Sattler, M. & Itzen, A., 17.03.2020, In: P NATL ACAD SCI USA. 117, 11, p. 5772-5781 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. 2019

  26. Phosphorylation of Ser111 in Rab8a Modulates Rabin8-Dependent Activation by Perturbation of Side Chain Interaction Networks

    Pourjafar-Dehkordi, D., Vieweg, S., Itzen, A. & Zacharias, M., 20.08.2019, In: BIOCHEMISTRY-US. 58, 33, p. 3546-3554 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a

    Sanzà, P., Evans, R. D., Briggs, D. A., Cantero, M., Montoliu, L., Patel, S., Sviderskaya, E. V., Itzen, A., Figueiredo, A. C., Seabra, M. C. & Hume, A. N., 30.04.2019, In: J CELL SCI. 132, 9

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. 2018

  29. The protease GtgE from Salmonella exclusively targets inactive Rab GTPases

    Wachtel, R., Bräuning, B., Mader, S. L., Ecker, F., Kaila, V. R. I., Groll, M. & Itzen, A., 01.2018, In: NAT COMMUN. 9, 1, p. 44

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. 2017

  31. Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo

    Cigler, M., Müller, T. G., Horn-Ghetko, D., von Wrisberg, M-K., Fottner, M., Goody, R. S., Itzen, A. & Lang, K., 04.12.2017, In: ANGEW CHEM INT EDIT. 56, 49, p. 15737-15741 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. 2016

  33. bMERB domains are bivalent Rab8 family effectors evolved by gene duplication

    Rai, A., Oprisko, A., Campos, J., Fu, Y., Friese, T., Itzen, A., Goody, R. S. & Gazdag, E. M., 23.08.2016, In: ELIFE. 5

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. A pull-down procedure for the identification of unknown GEFs for small GTPases

    Koch, D., Rai, A., Ali, I., Bleimling, N., Friese, T., Brockmeyer, A., Janning, P., Goud, B., Itzen, A. & Goody, R. S., 02.04.2016, In: Small GTPases. 7, 2, p. 93-106 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis

    Luitz, M. P., Bomblies, R., Ramcke, E., Itzen, A. & Zacharias, M., 28.01.2016, In: SCI REP-UK. 6, p. 19896

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. 2015

  37. Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

    Lai, Y-C., Kondapalli, C., Lehneck, R., Procter, J. B., Dill, B. D., Woodroof, H. I., Gourlay, R., Peggie, M., Macartney, T. J., Corti, O., Corvol, J-C., Campbell, D. G., Itzen, A., Trost, M. & Muqit, M. M., 12.11.2015, In: EMBO J. 34, 22, p. 2840-61 22 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Covalent Protein Labeling by Enzymatic Phosphocholination

    Heller, K., Ochtrop, P., Albers, M. F., Zauner, F. B., Itzen, A. & Hedberg, C., 24.08.2015, In: ANGEW CHEM INT EDIT. 54, 35, p. 10327-30 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Locking GTPases covalently in their functional states

    Wiegandt, D., Vieweg, S., Hofmann, F., Koch, D., Li, F., Wu, Y-W., Itzen, A. & Goody, R. S., 16.07.2015, In: NAT COMMUN. 6, p. 7773

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Molecular perspectives on protein adenylylation

    Hedberg, C. & Itzen, A., 16.01.2015, In: ACS CHEM BIOL. 10, 1, p. 12-21 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  41. 2014

  42. The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions

    Dolinsky, S., Haneburger, I., Cichy, A., Hannemann, M., Itzen, A. & Hilbi, H., 10.2014, In: INFECT IMMUN. 82, 10, p. 4021-33 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner

    Yin, G., Lopes da Fonseca, T., Eisbach, S. E., Anduaga, A. M., Breda, C., Orcellet, M. L., Szegő, É. M., Guerreiro, P., Lázaro, D. F., Braus, G. H., Fernandez, C. O., Griesinger, C., Becker, S., Goody, R. S., Itzen, A., Giorgini, F., Outeiro, T. F. & Zweckstetter, M., 10.2014, In: NEUROBIOL DIS. 70, p. 149-61 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy

    Gavriljuk, K., Schartner, J., Itzen, A., Goody, R. S., Gerwert, K. & Kötting, C., 02.07.2014, In: J AM CHEM SOC. 136, 26, p. 9338-45 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. The structure of the N-terminal domain of the Legionella protein SidC

    Gazdag, E. M., Schöbel, S., Shkumatov, A. V., Goody, R. S. & Itzen, A., 04.2014, In: J STRUCT BIOL. 186, 1, p. 188-94 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Direct targeting of Rab-GTPase-effector interactions

    Spiegel, J., Cromm, P. M., Itzen, A., Goody, R. S., Grossmann, T. N. & Waldmann, H., 24.02.2014, In: ANGEW CHEM INT EDIT. 53, 9, p. 2498-503 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting

    Li, F., Yi, L., Zhao, L., Itzen, A., Goody, R. S. & Wu, Y-W., 18.02.2014, In: P NATL ACAD SCI USA. 111, 7, p. 2572-7 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

    Langemeyer, L., Nunes Bastos, R., Cai, Y., Itzen, A., Reinisch, K. M. & Barr, F. A., 11.02.2014, In: ELIFE. 3, p. e01623

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Exploring adenylylation and phosphocholination as post-translational modifications

    Albers, M. F., Itzen, A. & Hedberg, C., 03.01.2014, In: CHEMBIOCHEM. 15, 1, p. 19-26 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  50. 2013

  51. Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB

    Guo, Z., Hou, X., Goody, R. S. & Itzen, A., 08.11.2013, In: J BIOL CHEM. 288, 45, p. 32466-74 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection

    Rothmeier, E., Pfaffinger, G., Hoffmann, C., Harrison, C. F., Grabmayr, H., Repnik, U., Hannemann, M., Wölke, S., Bausch, A., Griffiths, G., Müller-Taubenberger, A., Itzen, A. & Hilbi, H., 09.2013, In: PLOS PATHOG. 9, 9, p. e1003598

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy

    Gavriljuk, K., Itzen, A., Goody, R. S., Gerwert, K. & Kötting, C., 13.08.2013, In: P NATL ACAD SCI USA. 110, 33, p. 13380-5 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. RabGEFs are a major determinant for specific Rab membrane targeting

    Blümer, J., Rey, J., Dehmelt, L., Mazel, T., Wu, Y-W., Bastiaens, P., Goody, R. S. & Itzen, A., 04.02.2013, In: J CELL BIOL. 200, 3, p. 287-300 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  55. Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB

    Mihai Gazdag, E., Streller, A., Haneburger, I., Hilbi, H., Vetter, I. R., Goody, R. S. & Itzen, A., 02.2013, In: EMBO REP. 14, 2, p. 199-205 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  56. Protein-DNA arrays as tools for detection of protein-protein interactions by mass spectrometry

    Gogolin, L., Schroeder, H., Itzen, A., Goody, R. S., Niemeyer, C. M. & Becker, C. F. W., 02.01.2013, In: CHEMBIOCHEM. 14, 1, p. 92-9 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  57. Modulation of small GTPases by Legionella

    Goody, R. S. & Itzen, A., 2013, In: CURR TOP MICROBIOL. 376, p. 117-33 17 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  58. 2012

  59. Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail

    Gavriljuk, K., Gazdag, E-M., Itzen, A., Kötting, C., Goody, R. S. & Gerwert, K., 26.12.2012, In: P NATL ACAD SCI USA. 109, 52, p. 21348-53 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  60. Specific localization of Rabs at intracellular membranes

    Blümer, J., Wu, Y-W., Goody, R. S. & Itzen, A., 01.12.2012, In: BIOCHEM SOC T. 40, 6, p. 1421-5 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  61. Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein

    Shkumatov, A. V., Oesterlin, L. K., Schoebel, S., Goody, P. R., Goody, R. S. & Itzen, A., 12.10.2012, In: J BIOL CHEM. 287, 42, p. 35036-46 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  62. Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome

    Hagemann, N., Hou, X., Goody, R. S., Itzen, A. & Erdmann, K. S., 14.07.2012, In: Small GTPases. 3, 2, p. 107-10 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  63. Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor

    Oesterlin, L. K., Goody, R. S. & Itzen, A., 10.04.2012, In: P NATL ACAD SCI USA. 109, 15, p. 5621-6 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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