Research ExplorerResearch UnitsInstitute for Structure- and Systems Biology Publications

Institute for Structure- and Systems Biology

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Publications

  1. 2023

  2. New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development

    Seyfert, C. E., Müller, A. V., Walsh, D. J., Birkelbach, J., Kany, A. M., Porten, C., Yuan, B., Krug, D., Herrmann, J., Marlovits, T. C., Hirsch, A. K. H. & Müller, R., 14.12.2023, In: J MED CHEM. 66, 23, p. 16330-16341 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Structural basis for subversion of host cell actin cytoskeleton during Salmonella infection

    Yuan, B., Scholz, J., Wald, J., Thuenauer, R., Hennell James, R., Ellenberg, I., Windhorst, S., Faix, J. & Marlovits, T. C., 08.12.2023, In: SCI ADV. 9, 49, p. eadj5777

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

    Simonis, A., Kreer, C., Albus, A., Rox, K., Yuan, B., Holzmann, D., Wilms, J. A., Zuber, S., Kottege, L., Winter, S., Meyer, M., Schmitt, K., Gruell, H., Theobald, S. J., Hellmann, A-M., Meyer, C., Ercanoglu, M. S., Cramer, N., Munder, A., Hallek, M., Fätkenheuer, G., Koch, M., Seifert, H., Rietschel, E., Marlovits, T. C., van Koningsbruggen-Rietschel, S., Klein, F. & Rybniker, J., 09.11.2023, In: CELL. 186, 23, p. 5098-5113.e19

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in the outer membrane transport of proteins

    Bunduc, C. M., Ding, Y., Kuijl, C., Marlovits, T. C., Bitter, W. & Houben, E. N. G., 24.10.2023, In: MSPHERE. 8, 5, p. e0040223

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Holliday junction branch migration driven by AAA+ ATPase motors

    Wald, J. & Marlovits, T. C., 10.2023, In: CURR OPIN STRUC BIOL. 82, p. 102650

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  7. PickYOLO: Fast deep learning particle detector for annotation of cryo electron tomograms

    Genthe, E., Miletic, S., Tekkali, I., Hennell James, R., Marlovits, T. C. & Heuser, P., 09.2023, In: J STRUCT BIOL. 215, 3, p. 107990

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Residue-level error detection in cryoelectron microscopy models

    Reggiano, G., Lugmayr, W., Farrell, D., Marlovits, T. C. & DiMaio, F., 06.07.2023, In: STRUCTURE. 31, 7, p. 860-869.e4

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering

    Seyfert, C. E., Porten, C., Yuan, B., Deckarm, S., Panter, F., Bader, C., Coetzee, J., Deschner, F., Tehrani, K., Higgins, P. G., Seifert, H., Marlovits, T., Herrmann, J. & Müller, R., 09.01.2023, In: ANGEW CHEM INT EDIT. 62, 2, p. e202214094

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. StarMap: a user-friendly workflow for Rosetta-driven molecular structure refinement

    Lugmayr, W., Kotov, V., Goessweiner-Mohr, N., Wald, J., DiMaio, F. & Marlovits, T. C., 01.2023, In: NAT PROTOC. 18, 1, p. 239-264 26 p.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  11. 2022

  12. Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration

    Wald, J., Fahrenkamp, D., Goessweiner-Mohr, N., Lugmayr, W., Ciccarelli, L., Vesper, O. & Marlovits, T. C., 09.2022, In: NATURE. 609, 7927, p. 630-639 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Cryo-EM of the injectisome and type III secretion systems

    Bergeron, J. R. C. & Marlovits, T. C., 08.2022, In: CURR OPIN STRUC BIOL. 75, 102403.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  14. 2021

  15. Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes

    Killer, M., Wald, J., Pieprzyk, J., Marlovits, T. C. & Löw, C., 05.11.2021, In: SCI ADV. 7, 45, eabk3259.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Structural Dynamics of the Functional Nonameric Type III Translocase Export Gate

    Yuan, B., Portaliou, A. G., Parakra, R., Smit, J. H., Wald, J., Li, Y., Srinivasu, B., Loos, M. S., Dhupar, H. S., Fahrenkamp, D., Kalodimos, C. G., Duong van Hoa, F., Cordes, T., Karamanou, S., Marlovits, T. C. & Economou, A., 15.10.2021, In: J MOL BIOL. 433, 21, p. 167188

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Helical reconstruction of Salmonella and Shigella needle filaments attached to type 3 basal bodies

    Kotov, V., Lunelli, M., Wald, J., Kolbe, M. & Marlovits, T. C., 09.2021, In: BIOCHEM BIOPHYS REP. 27, p. 101039

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Structure and dynamics of a mycobacterial type VII secretion system

    Bunduc, C. M., Fahrenkamp, D., Wald, J., Ummels, R., Bitter, W., Houben, E. N. G. & Marlovits, T. C., 05.2021, In: NATURE. 593, 7859, p. 445-448 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Substrate-engaged type III secretion system structures reveal gating mechanism for unfolded protein translocation

    Miletic, S., Fahrenkamp, D., Goessweiner-Mohr, N., Wald, J., Pantel, M., Vesper, O., Kotov, V. & Marlovits, T. C., 09.03.2021, In: NAT COMMUN. 12, 1, 1546.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. In-depth interrogation of protein thermal unfolding data with MoltenProt

    Kotov, V., Mlynek, G., Vesper, O., Pletzer, M., Wald, J., Teixeira-Duarte, C. M., Celia, H., Garcia-Alai, M., Nussberger, S., Buchanan, S. K., Morais-Cabral, J. H., Loew, C., Djinovic-Carugo, K. & Marlovits, T. C., 01.2021, In: PROTEIN SCI. 30, 1, p. 201-217 17 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. 2020

  22. Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin

    Pinotsis, N., Zielinska, K., Babuta, M., Arolas, J. L., Kostan, J., Khan, M. B., Schreiner, C., Salmazo, A., Ciccarelli, L., Puchinger, M., Gkougkoulia, E. A., Ribeiro, E. D. A., Marlovits, T. C., Bhattacharya, A. & Djinovic-Carugo, K., 08.09.2020, In: P NATL ACAD SCI USA. 117, 36, p. 22101-22112 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol

    Chabloz, A., Schaefer, J. V., Kozieradzki, I., Cronin, S. J. F., Strebinger, D., Macaluso, F., Wald, J., Rabbitts, T. H., Plückthun, A., Marlovits, T. C. & Penninger, J. M., 03.07.2020, In: COMMUN BIOL. 3, 1, p. 342

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. 2019

  25. The Structure of the Type III Secretion System Needle Complex

    Miletic, S., Goessweiner-Mohr, N. & Marlovits, T. C., 31.10.2019, In: CURR TOP MICROBIOL.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site

    Wald, J., Pasin, M., Richter, M., Walther, C., Mathai, N., Kirchmair, J., Makarov, V. A., Goessweiner-Mohr, N., Marlovits, T. C., Zanella, I., Real-Hohn, A., Verdaguer, N., Blaas, D. & Schmidtke, M., 17.09.2019, In: P NATL ACAD SCI USA. 116, 38, p. 19109-19115 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. High-throughput stability screening for detergent-solubilized membrane proteins

    Kotov, V., Bartels, K., Veith, K., Josts, I., Subhramanyam, U. K. T., Günther, C., Labahn, J., Marlovits, T. C., Moraes, I., Tidow, H., Löw, C. & Garcia-Alai, M. M., 17.07.2019, In: SCI REP-UK. 9, 1, p. 10379

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion

    Guo, E. Z., Desrosiers, D. C., Zalesak, J., Tolchard, J., Berbon, M., Habenstein, B., Marlovits, T., Loquet, A. & Galán, J. E., 07.2019, In: PLOS BIOL. 17, 7, p. e3000351

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. 2017

  30. Control of type III protein secretion using a minimal genetic system

    Song, M., Sukovich, D. J., Ciccarelli, L., Mayr, J., Fernandez-Rodriguez, J., Mirsky, E. A., Tucker, A. C., Gordon, D. B., Marlovits, T. C. & Voigt, C. A., 09.05.2017, In: NAT COMMUN. 8, p. 14737

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis

    Beckham, K. S. H., Ciccarelli, L., Bunduc, C. M., Mertens, H. D. T., Ummels, R., Lugmayr, W., Mayr, J., Rettel, M., Savitski, M. M., Svergun, D. I., Bitter, W., Wilmanns, M., Marlovits, T. C., Parret, A. H. A. & Houben, E. N. G., 10.04.2017, In: NAT MICROBIOL. 2, p. 17047

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  32. 2016

  33. Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus

    Dietsche, T., Tesfazgi Mebrhatu, M., Brunner, M. J., Abrusci, P., Franz-Wachtel, M., Schärfe, C., Zilkenat, S., Grin, I., Galán, J. E., Kohlbacher, O., Lea, S., Macek, B., Marlovits, T. C., Robinson, C. V. & Wagner, S., 12.2016, In: PLOS PATHOG. 12, 12, p. e1006071

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states

    Smaldone, G., Pirone, L., Pedone, E., Marlovits, T., Vitagliano, L. & Ciccarelli, L., 06.2016, In: FEBS LETT. 590, 11, p. 1663-71 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. 2015

  36. Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

    DiMaio, F., Song, Y., Li, X., Brunner, M. J., Xu, C., Conticello, V., Egelman, E., Marlovits, T. C., Cheng, Y. & Baker, D., 04.2015, In: NAT METHODS. 12, 4, p. 361-5 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. 2014

  38. A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A

    Hornung, P., Troc, P., Malvezzi, F., Maier, M., Demianova, Z., Zimniak, T., Litos, G., Lampert, F., Schleiffer, A., Brunner, M., Mechtler, K., Herzog, F., Marlovits, T. C. & Westermann, S., 18.08.2014, In: J CELL BIOL. 206, 4, p. 509-24 16 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells

    Galán, J. E., Lara-Tejero, M., Marlovits, T. C. & Wagner, S., 01.01.2014, In: ANNU REV MICROBIOL. 68, p. 415-38 24 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Structure of a pathogenic type 3 secretion system in action

    Radics, J., Königsmaier, L. & Marlovits, T. C., 01.01.2014, In: NAT STRUCT MOL BIOL. 21, 1, p. 82-7 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. 2013

  42. Protein-mediated transformation of lipid vesicles into tubular networks

    Simunovic, M., Mim, C., Marlovits, T. C., Resch, G., Unger, V. M. & Voth, G. A., 06.08.2013, In: BIOPHYS J. 105, 3, p. 711-9 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. 2012

  44. Induced heterodimerization and purification of two target proteins by a synthetic coiled-coil tag.

    Fernandez-Rodriguez, J. & Marlovits, T., 2012, In: PROTEIN SCI. 21, 4, p. 511-519 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. The blueprint of the type-3 injectisome.

    Kosarewicz, A., Königsmaier, L. & Marlovits, T., 2012, In: PHILOS T R SOC B. 367, 1592, p. 1140-1154 1592.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. 2011

  47. Entry of a heparan sulphate-binding HRV8 variant strictly depends on dynamin but not on clathrin, caveolin, and flotillin.

    Khan, A. G., Pickl-Herk, A., Gajdzik, L., Marlovits, T., Fuchs, R. & Blaas, D., 2011, In: VIROLOGY. 412, 1, p. 55-67 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Three-dimensional model of Salmonella's needle complex at subnanometer resolution.

    Schraidt, O. & Marlovits, T., 2011, In: SCIENCE. 331, 6021, p. 1192-1195 6021.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. 2010

  50. Human rhinovirus 14 enters rhabdomyosarcoma cells expressing icam-1 by a clathrin-, caveolin-, and flotillin-independent pathway.

    Khan, A. G., Pickl-Herk, A., Gajdzik, L., Marlovits, T., Fuchs, R. & Blaas, D., 2010, In: J VIROL. 84, 8, p. 3984-3992 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Organization and coordinated assembly of the type III secretion export apparatus.

    Wagner, S., Königsmaier, L., Lara-Tejero, M., Lefebre, M., Marlovits, T. & Galán, J. E., 2010, In: P NATL ACAD SCI USA. 107, 41, p. 17745-17750 41.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. The structure of the Salmonella typhimurium type III secretion system needle shows divergence from the flagellar system.

    Galkin, V. E., Schmied, W. H., Schraidt, O., Marlovits, T. & Egelman, E. H., 2010, In: J MOL BIOL. 396, 5, p. 1392-1397 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. Topology and organization of the Salmonella typhimurium type III secretion needle complex components.

    Schraidt, O., Lefebre, M. D., Brunner, M. J., Schmied, W. H., Schmidt, A., Radics, J., Mechtler, K., Galán, J. E. & Marlovits, T., 2010, In: PLOS PATHOG. 6, 4, p. 1000824 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. Type III secretion systems shape up as they ship out.

    Marlovits, T. & Stebbins, C. E., 2010, In: CURR OPIN MICROBIOL. 13, 1, p. 47-52 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review