Institute of Pathology

Publications

  1. 2003
  2. FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomas.

    Milde-Langosch, K., Kappes, H., Riethdorf, S., Löning, T. & Bamberger, A-M., 2003, In: BREAST CANCER RES TR. 77, 3, p. 265-275 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. HER-2 and TOP2A coamplification in urinary bladder cancer.

    Simon, R., Atefy, R., Wagner, U., Forster, T., Fijan, A., Bruderer, J., Wilber, K., Mihatsch, M. J., Gasser, T. & Sauter, G., 2003, In: INT J CANCER. 107, 5, p. 764-772 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. High-throughput tissue microarray analysis of 11q13 gene amplification (CCND1, FGF3, FGF4, EMS1) in urinary bladder cancer.

    Zaharieva, B. M., Simon, R., Diener, P-A., Ackermann, D., Maurer, R., Alund, G., Knönagel, H., Rist, M., Wilber, K., Hering, F., Schönenberger, A., Flury, R., Jäger, P., Fehr, J. L., Mihatsch, M. J., Gasser, T., Sauter, G. & Toncheva, D. I., 2003, In: J PATHOL. 201, 4, p. 603-608 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  5. Methylation-specific PCR for DNA-based detection of occult tumor cells in lymph nodes of prostate cancer patients.

    Köllermann, J., Müller, M., Goessl, C., Krause, H., Helpap, B., Pantel, K. & Miller, K., 2003, In: EUR UROL. 44, 5, p. 533-538 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  6. New hepatitis B virus of cranes that has an unexpected broad host range.

    Prassolov, A., Hohenberg, H., Kalinina, T., Schneider, C., Cova, L., Krone, O., Frölich, K., Will, H. & Sirma, H., 2003, In: J VIROL. 77, 3, p. 1964-1976 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  7. Oral lichen planus in patients with chronic liver diseases.

    Friedrich, R. E., Heiland, M., El-Moawen, A., Dogan, A., von Schrenck, T. & Löning, T., 2003, In: INFECTION. 31, 6, p. 383-386 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  8. PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.

    Möller, A., Sirma, H., Hofmann, T. G., Rueffer, S., Klimczak, E., Dröge, W., Will, H. & Schmitz, M. L., 2003, In: CANCER RES. 63, 15, p. 4310-4314 15.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  9. Quantitative assessment of HER-2/neu protein concentration in breast cancer by enzyme-linked immunosorbent assay.

    Müller, V., Thomssen, C., Karakas, C., Eustermann, I., Ramirez Porras, J., Coith, C., Berger, J., Löning, T., Jänicke, F. & Pantel, K., 2003, In: INT J BIOL MARKER. 18, 1, p. 13-20 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  10. Sequence analysis and high-throughput immunohistochemical profiling of KIT (CD 117) expression in uveal melanoma using tissue microarrays.

    Pache, M., Glatz, K., Bösch, D., Dirnhofer, S., Mirlacher, M., Simon, R., Schraml, P., Rufle, A., Flammer, J., Sauter, G. & Meyer, P., 2003, In: VIRCHOWS ARCH. 443, 6, p. 741-744 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  11. Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.

    Möller, A., Sirma, H., Hofmann, T. G., Staege, H., Gresko, E., Schmid, L. K., Klimczak, E., Dröge, W., Will, H. & Schmitz, M. L., 2003, In: ONCOGENE. 22, 54, p. 8731-8737 54.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. Tissue microarrays in cancer diagnosis.

    Simon, R., Mirlacher, M. & Sauter, G., 2003, In: EXPERT REV MOL DIAGN. 3, 4, p. 421-430 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  13. Tissue microarrays in drug discovery.

    Sauter, G., Simon, R. & Hillan, K., 2003, In: NAT REV DRUG DISCOV. 2, 12, p. 962-972 12.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  14. Tissue microarray (TMA) applications: implications for molecular medicine.

    Simon, R. & Sauter, G., 2003, In: EXPERT REV MOL MED. 5, 26, p. 1-12 26.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  15. Translocations t(11;18)(q21;q21) and t(14;18)(q32;q21) are the main chromosomal abnormalities involving MLT/MALT1 in MALT lymphomas.

    Murga-Penas, E-M., Hinz, K., Röser, K., Copie-Bergman, C., Wlodarska, I., Marynen, P., Hagemeijer, A., Gaulard, P., Löning, T., Hossfeld, D. K. & Dierlamm, J., 2003, In: LEUKEMIA. 17, 11, p. 2225-2229 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. 2002
  17. Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer.

    Simon, R., Struckmann, K., Schraml, P., Wagner, U., Forster, T., Moch, H., Fijan, A., Bruderer, J., Wilber, K., Mihatsch, M. J., Gasser, T. & Sauter, G., 2002, In: ONCOGENE. 21, 16, p. 2476-2483 16.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. Analysis of the progression of fibroepithelial tumours of the breast by PCR-based clonality assay.

    Kuijper, A., Buerger, H., Simon, R., Schaefer, K-L., Croonen, A., Boecker, W., van der Wall, E., Diest, V. & Paul, J., 2002, In: J PATHOL. 197, 5, p. 575-581 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  19. Expression of the adhesion molecule CEACAM1 (CD66a, BGP, C-CAM) in breast cancer is associated with the expression of the tumor-suppressor genes Rb, Rb2, and p27.

    Bamberger, A-M., Kappes, H., Methner, C., Rieck, G., Brümmer, J., Wagener, C., Löning, T. & Milde-Langosch, K., 2002, In: VIRCHOWS ARCH. 440, 2, p. 139-144 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  20. [HER-2 and TOP2A gene amplification in urinary bladder cancer]

    Simon, R., Atefy, R., Wagner, U., Forster, T., Fijan, A., Bruderer, J., Wilber, K., Mihatsch, M., Gasser T, G. & Sauter, G., 2002, In: Verh Dtsch Ges Pathol. 86, p. 176-183

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  21. [HER-2 and TOP 2A gene amplifications in urinary bladder carcinoma]

    Simon, R., Atefy, R., Wagner, U., Forster, T., Fijan, A., Bruderer, J., Wilber, K., Mihatsch, M. J., Gasser, T. & Sauter, G., 2002, In: Verh Dtsch Ges Pathol. 86, p. 176-183

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  22. Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors.

    Solakoglu, O., Maierhofer, C., Lahr, G., Breit, E., Scheunemann, P., Heumos, I., Pichlmeier, U., Schlimok, G., Oberneder, R., Kollermann, M. W., Köllermann, J., Speicher, M. R. & Pantel, K., 2002, In: P NATL ACAD SCI USA. 99, 4, p. 2246-2251 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia.

    Riethdorf, L., Riethdorf, S., Lee, K. R., Cviko, A., Löning, T. & Crum, C. P., 2002, In: HUM PATHOL. 33, 9, p. 899-904 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. [Molecular genetics of urinary bladder cancer progression]

    Sauter, G., Simon, R., Bubendorf, L. & Mihatsch, M., 2002, In: Verh Dtsch Ges Pathol. 86, p. 49-56

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  25. Patterns of chromosomal aberrations in urinary bladder tumours and adjacent urothelium.

    Steidl, C., Simon, R., Bürger, H., Brinkschmidt, C., Hertle, L., Böcker, W. & Terpe, H-J., 2002, In: J PATHOL. 198, 1, p. 115-120 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  26. Predictive molecular pathology.

    Sauter, G. & Simon, R., 2002, In: NEW ENGL J MED. 347, 25, p. 1995-1996 25.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  27. Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.

    Kocher, T., Zheng, M., Bolli, M., Simon, R., Forster, T., Schultz-Thater, E., Remmel, E., Noppen, C., Schmid, U., Ackermann, D., Mihatsch, M. J., Gasser, T., Heberer, M., Sauter, G. & Spagnoli, G. C., 2002, In: INT J CANCER. 100, 6, p. 702-705 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  28. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.

    Hofmann, T. G., Möller, A., Sirma, H., Zentgraf, H., Taya, Y., Dröge, W., Will, H. & Schmitz, M. L., 2002, In: NAT CELL BIOL. 4, 1, p. 1-10 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  29. Relative paucity of gross genetic alterations in myoepitheliomas and myoepithelial carcinomas of salivary glands.

    Hungermann, D., Roeser, K., Buerger, H., Jäkel, T., Löning, T. & Herbst, H., 2002, In: J PATHOL. 198, 4, p. 487-494 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Tissue microarrays for miniaturized high-throughput molecular profiling of tumors.

    Simon, R. & Sauter, G., 2002, In: EXP HEMATOL. 30, 12, p. 1365-1372 12.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  31. 2001
  32. Phänotyp-Genotyp-Korrelationen in Speicheldrüsentumoren - Stellenwert der molekularen Analytik -

    Röser, K. & Löning, T., 11.2001, In: LARYNGO RHINO OTOL. 80, 11, p. 639-41 3 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  33. Pilotstudie zur prognostischen Wertigkeit der Her-2 Genamplifikation und Proliferationsaktivität beim Speichelgangkarzinom der grossen Kopfspeicheldrüsen1

    Jaehne, M., Jäkel, K. T., Röser, K., Ussmüller, J. & Löning, T., 09.2001, In: LARYNGO RHINO OTOL. 80, 9, p. 525-529 5 p., 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. Expression of Rb2/p130 in breast and endometrial cancer: correlations with hormone receptor status.

    Milde-Langosch, K., Goemann, C., Methner, C., Rieck, G., Bamberger, A. M. & Löning, T., 17.08.2001, In: BRIT J CANCER. 85, 4, p. 546-551 6 p., 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. p53-Mutationsnachweis in Abstrichen der Mundschleimhaut von Patienten mit oralem Plattenepithelkarzinom

    Giese, M., Friedrich, R. E., Riethdorf, S. & Löning, T., 01.01.2001, In: Mund Kiefer Gesichtschir. 5, 1, p. 37-43 7 p., 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  36. Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression.

    Simon, M., Park, T. W., Köster, G., Mahlberg, R., Hackenbroch, M., Boström, J., Löning, T. & Schramm, J., 2001, In: J NEURO-ONCOL. 55, 3, p. 149-158 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. A unique exonic splicing mutation in the human androgen receptor gene indicates a physiologic relevance of regular androgen receptor transcript variants.

    Hellwinkel, O., Holterhus, P. M., Struve, D., Marschke, C., Homburg, N. & Hiort, O., 2001, In: J CLIN ENDOCR METAB. 86, 6, p. 2569-2575 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Comparative genomic hybridization in pineal parenchymal tumors.

    Rickert, C. H., Simon, R., Bergmann, M., Dockhorn-Dworniczak, B. & Paulus, W., 2001, In: GENE CHROMOSOME CANC. 30, 1, p. 99-104 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. Cytogenetic analysis of multifocal bladder cancer supports a monoclonal origin and intraepithelial spread of tumor cells.

    Simon, R., Eltze, E., Schäfer, K. L., Bürger, H., Semjonow, A., Hertle, L., Dockhorn-Dworniczak, B., Terpe, H. J. & Böcker, W., 2001, In: CANCER RES. 61, 1, p. 355-362 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  40. Distal chromosome 17 gains in neuroblastomas detected by comparative genomic hybridization (CGH) are associated with a poor clinical outcome.

    Brinkschmidt, C., Christiansen, H., Terpe, H. J., Simon, R., Lampert, F., Boecker, W. & Dockhorn-Dworniczak, B., 2001, In: Med Pediatr Oncol. 36, 1, p. 11-13 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution.

    Buerger, H., Mommers, E. C., Littmann, R., Simon, R., Diallo, R., Poremba, C., Dockhorn-Dworniczak, B., van Diest, P. J. & Boecker, W., 2001, In: J PATHOL. 194, 2, p. 165-170 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  42. Expression of cell-cycle regulatory proteins in endometrial carcinomas: correlations with hormone receptor status and clinicopathologic parameters.

    Milde-Langosch, K., Bamberger, A. M., Goemann, C., Rössing, E., Rieck, G., Kelp, B. & Löning, T., 2001, In: J CANCER RES CLIN. 127, 9, p. 537-544 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  43. Expression of cyclin-dependent kinase inhibitors p16MTS1, p21WAF1, and p27KIP1 in HPV-positive and HPV-negative cervical adenocarcinomas.

    Milde-Langosch, K., Riethdorf, S., Kraus-Pöppinghaus, A., Riethdorf, L. & Löning, T., 2001, In: VIRCHOWS ARCH. 439, 1, p. 55-61 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. Expression of vascular endothelial growth factor (VEGF) and VEGF receptor Flk-1 in benign, premalignant, and malignant prostate tissue.

    Köllermann, J. & Helpap, B., 2001, In: AM J CLIN PATHOL. 116, 1, p. 115-121 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  45. Expression pattern of the adhesion molecule CEACAM1 (C-CAM, CD66a, BGP) in gestational trophoblastic lesions.

    Bamberger, A. M., Sudahl, S., Wagener, C. & Löning, T., 2001, In: INT J GYNECOL PATHOL. 20, 2, p. 160-165 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  46. Expression pattern of the AP-1 family in endometrial cancer: correlations with cell cycle regulators.

    Bamberger, A. M., Milde-Langosch, K., Rössing, E., Goemann, C. & Löning, T., 2001, In: J CANCER RES CLIN. 127, 9, p. 545-550 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  47. Frequent p16/MTS1 inactivation in early stages of urothelial carcinoma of the bladder is not associated with tumor recurrence.

    Friedrich, M., Blind, C., Milde-Langosch, K., Erbersdobler, A., Conrad, S., Löning, T., Hammerer, P. & Huland, H., 2001, In: EUR UROL. 40, 5, p. 518-524 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  48. Gene-expression profiles in hereditary breast cancer.

    Hedenfalk, I., Duggan, D., Chen, Y., Radmacher, M., Bittner, M., Simon, R., Meltzer, P., Gusterson, B., Esteller, M., Kallioniemi, O. P., Wilfond, B., Borg, A., Trent, J., Raffeld, M., Yakhini, Z., Ben-Dor, A., Dougherty, E., Kononen, J., Bubendorf, L., Fehrle, W., Pittaluga, S., Gruvberger, S., Loman, N., Johannsson, O., Olsson, H. & Sauter, G., 2001, In: NEW ENGL J MED. 344, 8, p. 539-548 8.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  49. High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer.

    Simon, R., Richter, J., Wagner, U., Fijan, A., Bruderer, J., Schmid, U., Ackermann, D., Maurer, R., Alund, G., Knönagel, H., Rist, M., Wilber, K., Anabitarte, M., Hering, F., Hardmeier, T., Schönenberger, A., Flury, R., Jäger, P., Fehr, J. L., Schraml, P., Moch, H., Mihatsch, M. J., Gasser, T. & Sauter, G., 2001, In: CANCER RES. 61, 11, p. 4514-4519 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  50. Identification and analysis of a new hepadnavirus in white storks.

    Pult, I., Netter, H. J., Bruns, M., Prassolov, A., Sirma, H., Hohenberg, H., Chang, S. F., Frölich, K., Krone, O., Kaleta, E. F. & Will, H., 2001, In: VIROLOGY. 289, 1, p. 114-128 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  51. Immunohistochemical analysis of the proliferative activity of neuroendocrine tumors from various organs. Are there indications for a neuroendocrine tumor-carcinoma sequence?

    Helpap, B. & Köllermann, J., 2001, In: VIRCHOWS ARCH. 438, 1, p. 86-91 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  52. Limiting the diagnosis of atypical small glandular proliferations in needle biopsies of the prostate by the use of immunohistochemistry.

    Helpap, B., Köllermann, J. & Oehler, U., 2001, In: J PATHOL. 193, 3, p. 350-353 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  53. MAGE-A gene expression pattern in primary breast cancer.

    Otte, M., Zafrakas, M., Riethdorf, L., Pichlmeier, U., Löning, T., Jänicke, F. & Pantel, K., 2001, In: CANCER RES. 61, 18, p. 6682-6687 18.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review