Zosteropenillines: Polyketides from the Marine-Derived Fungus Penicillium thomii
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Zosteropenillines: Polyketides from the Marine-Derived Fungus Penicillium thomii. / Afiyatullov, Shamil Sh; Leshchenko, Elena V; Berdyshev, Dmitrii V; Sobolevskaya, Maria P; Antonov, Alexandr S; Denisenko, Vladimir A; Popov, Roman S; Pivkin, Mikhail V; Udovenko, Anatoly A; Pislyagin, Evgeny A; von Amsberg, Gunhild; Dyshlovoy, Sergey A; Kerr, Russell (Redakteur/-in).
in: MAR DRUGS, Jahrgang 15, Nr. 2, 02.2017, S. 46.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Zosteropenillines: Polyketides from the Marine-Derived Fungus Penicillium thomii
AU - Afiyatullov, Shamil Sh
AU - Leshchenko, Elena V
AU - Berdyshev, Dmitrii V
AU - Sobolevskaya, Maria P
AU - Antonov, Alexandr S
AU - Denisenko, Vladimir A
AU - Popov, Roman S
AU - Pivkin, Mikhail V
AU - Udovenko, Anatoly A
AU - Pislyagin, Evgeny A
AU - von Amsberg, Gunhild
AU - Dyshlovoy, Sergey A
A2 - Kerr, Russell
PY - 2017/2
Y1 - 2017/2
N2 - Twelve new polyketides, zosteropenillines A–L (1–12), together with known polyketide pallidopenilline A (13), were isolated from the ethylacetate extract of the fungus Penicillium thomii associated with the seagrass Zostera marina. Their structures were established based on spectroscopic methods. The absolute configuration of zosteropenilline A (1) as 4R, 5S, 8S, 9R, 10R, and 13S was determined by a combination of the modified Mosher’s method, X-ray analysis, and NOESY data. Absolute configurations of zosteropenillines B–D (2–4) were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. The effect of compounds 1–3, 7, 8, 10, and 11 on the viability of human drug-resistant prostate cancer cells PC3 as well as on autophagy in these cancer cells and inhibitory effects of compounds 1, 2, and 8–10 on NO production in LPS-induced RAW 264.7 murine macrophages were examined.
AB - Twelve new polyketides, zosteropenillines A–L (1–12), together with known polyketide pallidopenilline A (13), were isolated from the ethylacetate extract of the fungus Penicillium thomii associated with the seagrass Zostera marina. Their structures were established based on spectroscopic methods. The absolute configuration of zosteropenilline A (1) as 4R, 5S, 8S, 9R, 10R, and 13S was determined by a combination of the modified Mosher’s method, X-ray analysis, and NOESY data. Absolute configurations of zosteropenillines B–D (2–4) were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. The effect of compounds 1–3, 7, 8, 10, and 11 on the viability of human drug-resistant prostate cancer cells PC3 as well as on autophagy in these cancer cells and inhibitory effects of compounds 1, 2, and 8–10 on NO production in LPS-induced RAW 264.7 murine macrophages were examined.
U2 - 10.3390/md15020046
DO - 10.3390/md15020046
M3 - SCORING: Journal article
VL - 15
SP - 46
JO - MAR DRUGS
JF - MAR DRUGS
SN - 1660-3397
IS - 2
ER -