Zooming in on the small: the plasticity of striatal dendritic spines in L-DOPA-induced dyskinesia
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Zooming in on the small: the plasticity of striatal dendritic spines in L-DOPA-induced dyskinesia. / Fieblinger, Tim; Cenci, M Angela.
in: MOVEMENT DISORD, Jahrgang 30, Nr. 4, 04.2015, S. 484-93.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Zooming in on the small: the plasticity of striatal dendritic spines in L-DOPA-induced dyskinesia
AU - Fieblinger, Tim
AU - Cenci, M Angela
N1 - © 2015 International Parkinson and Movement Disorder Society.
PY - 2015/4
Y1 - 2015/4
N2 - The spiny dendrites of striatal projection neurons integrate synaptic inputs of different origins to regulate movement. It has long been known that these dendrites lose spines and display atrophic features in Parkinson's disease (PD), but the significance of these morphological changes has remained unknown. Some recent studies reveal a remarkable structural plasticity of striatal spines in parkinsonian rodents treated with L-3,4-dihydroxyphenylalanine (L-DOPA), and they demonstrate an association between this plasticity and the development of dyskinesia. These studies used different approaches and animal models, which possibly explains why they emphasize different plastic changes as being most closely linked to dyskinesia (such as a growth of new spines in neurons of the indirect pathway, or a loss of spines in neurons of the direct pathway, or the appearance of spines with aberrant synaptic features). Clearly, further investigations are required to reconcile these intriguing findings and integrate them in a coherent pathophysiological model. Nevertheless, these studies may mark the beginning of a new era for dyskinesia research. In addition to addressing neurochemical and molecular events that trigger involuntary movements, there is a need to better understand the long-lasting structural reorganization of cells and circuits that maintain the brain in a "dyskinesia-prone" state. This may lead to the identification of new efficacious approaches to prevent the complications of dopaminergic therapies in PD.
AB - The spiny dendrites of striatal projection neurons integrate synaptic inputs of different origins to regulate movement. It has long been known that these dendrites lose spines and display atrophic features in Parkinson's disease (PD), but the significance of these morphological changes has remained unknown. Some recent studies reveal a remarkable structural plasticity of striatal spines in parkinsonian rodents treated with L-3,4-dihydroxyphenylalanine (L-DOPA), and they demonstrate an association between this plasticity and the development of dyskinesia. These studies used different approaches and animal models, which possibly explains why they emphasize different plastic changes as being most closely linked to dyskinesia (such as a growth of new spines in neurons of the indirect pathway, or a loss of spines in neurons of the direct pathway, or the appearance of spines with aberrant synaptic features). Clearly, further investigations are required to reconcile these intriguing findings and integrate them in a coherent pathophysiological model. Nevertheless, these studies may mark the beginning of a new era for dyskinesia research. In addition to addressing neurochemical and molecular events that trigger involuntary movements, there is a need to better understand the long-lasting structural reorganization of cells and circuits that maintain the brain in a "dyskinesia-prone" state. This may lead to the identification of new efficacious approaches to prevent the complications of dopaminergic therapies in PD.
KW - Animals
KW - Antiparkinson Agents/adverse effects
KW - Corpus Striatum/pathology
KW - Dendritic Spines/drug effects
KW - Dyskinesia, Drug-Induced/etiology
KW - Humans
KW - Levodopa/adverse effects
KW - Neuronal Plasticity/drug effects
KW - Neurons/pathology
U2 - 10.1002/mds.26139
DO - 10.1002/mds.26139
M3 - SCORING: Review article
C2 - 25759263
VL - 30
SP - 484
EP - 493
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 4
ER -