Zeitfaktor und Zeit-Dosis-Verschreibung in der Strahlentherapie von Kopf-Hals-Tumoren
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Zeitfaktor und Zeit-Dosis-Verschreibung in der Strahlentherapie von Kopf-Hals-Tumoren. / Dubben, H H.
in: STRAHLENTHER ONKOL, Jahrgang 170, Nr. 2, 01.02.1994, S. 101-2.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Zeitfaktor und Zeit-Dosis-Verschreibung in der Strahlentherapie von Kopf-Hals-Tumoren
AU - Dubben, H H
PY - 1994/2/1
Y1 - 1994/2/1
N2 - BACKGROUND: Clinical data on head and neck tumors presented by Withers et al. are reexamined. Recently it was argued that the relationship between TCD50 and treatment time might be influenced by the practice of prescription.METHOD: In a computer simulation the impact of treatment outcome on the time factor is investigated. For this the genuine local tumor control rates were replaced by either tumor failure rate or by random numbers.RESULTS: The time factor is independent from local tumor control rates in all simulations.CONCLUSIONS: The increase of TCD50 with treatment time reflects solely dose-time prescription habits. The data provide no significant evidence either for an impact of treatment duration or for repopulation during radiotherapy in head and neck tumors.
AB - BACKGROUND: Clinical data on head and neck tumors presented by Withers et al. are reexamined. Recently it was argued that the relationship between TCD50 and treatment time might be influenced by the practice of prescription.METHOD: In a computer simulation the impact of treatment outcome on the time factor is investigated. For this the genuine local tumor control rates were replaced by either tumor failure rate or by random numbers.RESULTS: The time factor is independent from local tumor control rates in all simulations.CONCLUSIONS: The increase of TCD50 with treatment time reflects solely dose-time prescription habits. The data provide no significant evidence either for an impact of treatment duration or for repopulation during radiotherapy in head and neck tumors.
KW - Computer Simulation
KW - Head and Neck Neoplasms
KW - Humans
KW - Radiotherapy Dosage
KW - Time Factors
M3 - SCORING: Zeitschriftenaufsatz
C2 - 8108774
VL - 170
SP - 101
EP - 102
JO - STRAHLENTHER ONKOL
JF - STRAHLENTHER ONKOL
SN - 0179-7158
IS - 2
ER -